iPTMnet Report for P06786 (TOP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06786 / TOP2_YEAST
Protein Name DNA topoisomerase 2
Gene Name Name: TOP2
Synonyms:TOR3;OrderedLocusNames:YNL088W;ORFNames:N2244;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

PRO ID PR:P06786
DAG View
PRO Name DNA topoisomerase 2 (yeast)
Definition A protein that is a translation product of the TOP2 gene in yeast.
Short Label yTOP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06786 (TOP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation SGD 33491328
S9 Phosphorylation SGD 33491328
K11 Acetylation SGD 22865919
K11 Sumoylation SGD 33502312
K14 Sumoylation SGD 33502312
S128 Phosphorylation BioGRID   SGD 19779198
Y130 Phosphorylation BioGRID   SGD 19779198
S717 Phosphorylation SGD 33491328
T1086 Phosphorylation phospho.ELM   BioGRID   SGD   UniProt 19779198, 1316274, 1332607
S1087 Phosphorylation phospho.ELM   BioGRID   SGD   UniProt 19779198, 1316274, 1332607
S1094 Phosphorylation BioGRID   SGD 19779198
K1220 Sumoylation SGD 33502312, 12086615
K1246 Sumoylation SGD 12086615
K1247 Sumoylation SGD 12086615
T1250 Phosphorylation BioGRID   SGD 33481703, 17563356, 33491328, ...19779198, 33502312, 32597660, 23749301
S1252 Phosphorylation BioGRID   SGD   UniProt 19779198, 33491328, 33481703, ...33502312
S1254 Phosphorylation SGD 33502312, 23749301
T1256 Phosphorylation SGD 33502312, 33481703
K1257 Sumoylation SGD 33502312
T1258 Phosphorylation phospho.ELM   SGD   UniProt 33502312, 1332607, 1316274, ...23749301, 33491328
S1266 Phosphorylation phospho.ELM   SGD   UniProt 33502312, 1316274, 33491328, ...1332607
S1267 Phosphorylation SGD 33502312, 23749301, 33491328
T1268 Phosphorylation BioGRID   SGD 33502312, 33491328, 18407956
S1269 Phosphorylation phospho.ELM   BioGRID   SGD   UniProt 33502312, 1316274, 33491328, ...18407956, 1332607
S1270 Phosphorylation SGD 23749301, 33491328
S1272 Phosphorylation phospho.ELM   UniProt 1316274, 1332607
K1277 Sumoylation SGD 33502312, 12086615
K1277 Ubiquitination SGD 25344756
K1278 Sumoylation SGD 33502312, 12086615
S1290 Phosphorylation BioGRID 19795423, 19823750
S1297 Phosphorylation SGD 23749301, 33491328
S1305 Phosphorylation BioGRID   SGD 21177495, 19684113, 32597660, ...33491328
T1306 Phosphorylation BioGRID   SGD 17330950, 33491328, 17563356
S1307 Phosphorylation BioGRID   SGD 19779198, 21177495, 23749301, ...33491328
T1309 Phosphorylation BioGRID   SGD 21177495, 20702584, 33481703, ...17563356, 33491328
S1310 Phosphorylation BioGRID   SGD 33481703, 17563356, 32597660, ...20702584, 33491328, 19779198, 21177495, 23749301
T1314 Phosphorylation BioGRID   SGD 19795423, 33481703, 17563356, ...17330950, 21177495, 20702584, 21126336, 23749301, 22218487, 19779198, 19684113, 32597660, 33491328, 19823750
S1353 Phosphorylation phospho.ELM   BioGRID   SGD   UniProt 19779198, 1316274, 1332607
S1356 Phosphorylation phospho.ELM   BioGRID   SGD   UniProt 19779198, 1316274, 10094396, ...1332607
S1356 Phosphorylation P15790 (CKA1) BioGRID 19779198, 10094396
S1356 Phosphorylation P19454 (CKA2) BioGRID 19779198, 10094396
S1363 Phosphorylation BioGRID 10094396
S1363 Phosphorylation P15790 (CKA1) BioGRID 10094396
S1363 Phosphorylation P19454 (CKA2) BioGRID 10094396
T1365 Phosphorylation BioGRID 10094396
T1365 Phosphorylation P15790 (CKA1) BioGRID 10094396
T1365 Phosphorylation P19454 (CKA2) BioGRID 10094396
S1370 Phosphorylation BioGRID   SGD 19779198, 33481703, 33491328
S1392 Phosphorylation SGD 32597660, 33491328
S1408 Phosphorylation phospho.ELM   UniProt 1316274, 1332607
S1423 Phosphorylation phospho.ELM   UniProt 1316274, 1332607