Protein Information

Cytoscape View


UniProt AC / UniProt ID P06753 / TPM3_HUMAN
Protein Name Tropomyosin alpha-3 chain
Gene Name Name: TPM3
Organism Homo sapiens (Human)

PRO ID PR:P06753
DAG View
PRO Name tropomyosin alpha-3 chain (human)
Definition A tropomyosin alpha-3 chain that is encoded in the genome of human.
Short Label hTPM3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06753 (TPM3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus   UniProt 23186163
T109 Phosphorylation PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K119 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
K129 Sumoylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K150 Acetylation PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
R161 Methylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
R179 Methylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K221 Methylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation HPRD 19664994
S192 Phosphorylation HPRD 18452278
T253 Phosphorylation HPRD 15302935
S284 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
T6 Phosphorylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
T216 Phosphorylation HPRD   PhosphoSitePlus 18669648, 15302935
K223 Acetylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S155 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S155 Phosphorylation HPRD 18452278
T216 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y61 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S124 R124 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K150 Q150 Biomuta DOID:3571 / liver cancer [ icgc ]
K153 M153 Biomuta DOID:1909 / melanoma [ cosmic ]
K162 Q162 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y163 H163 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
R179 H179 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R179 L179 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K227 N227 Biomuta DOID:363 / uterine cancer [ tcga ]
K232 N232 Biomuta DOID:3277 / thymus cancer [ tcga ]
T238 A238 Biomuta DOID:1909 / melanoma [ cosmic ]
K249 N249 Biomuta DOID:1324 / lung cancer [ tcga ]