iPTMnet Report for P06746 (POLB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06746 / DPOLB_HUMAN
Protein Name DNA polymerase beta
Gene Name Name: POLB
Organism Homo sapiens (Human)

PRO ID PR:P06746
DAG View
PRO Name DNA polymerase beta (human)
Definition A DNA polymerase beta that is encoded in the genome of human.
Short Label hPOLB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06746 (POLB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
Y36 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus   UniProt 19713937, 21362556
S44 Phosphorylation HPRD   PhosphoSitePlus 2040602
Y49 Phosphorylation PhosphoSitePlus
S55 Phosphorylation HPRD   PhosphoSitePlus 2040602
K61 Ubiquitination PhosphoSitePlus   UniProt 19713937, 21362556
T67 Phosphorylation PhosphoSitePlus
K72 Acetylation PR:000007102 (EP300) PRO   PhosphoSitePlus 12453427
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus   UniProt 19713937, 21362556
R83 Methylation PhosphoSitePlus   UniProt 16600869
K113 Acetylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K141 Sumoylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
R152 Methylation PhosphoSitePlus   UniProt 16600869
S180 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
R258 Methylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028604 (hPOLB/Ac:1) acK72 PR:000007102 (EP300) PRO 12453427
PR:000048840 (hPOLB/InitMet-/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 C44 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y49 S49 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R83 C83 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
R83 H83 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R152 C152 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R152 H152 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R152 P152 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y322 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y322 C322 Biomuta DOID:9256 / colorectal cancer [ cosmic ]