iPTMnet Report for P06744 (GPI)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06744 / G6PI_HUMAN
Protein Name Glucose-6-phosphate isomerase
Gene Name Name: GPI
Organism Homo sapiens (Human)

PRO ID PR:P06744
DAG View
PRO Name glucose-6-phosphate isomerase (human)
Definition A glucose-6-phosphate isomerase that is encoded in the genome of human.
Short Label hGPI
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06744 (GPI) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K12 Acetylation PhosphoSitePlus   UniProt 19608861
K12 Methylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
R66 Methylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
N86 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
N91 N-Glycosylation GlyGen 29741879
Y92 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
R106 Methylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus   UniProt 23186163
T109 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
K116 Acetylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
C133 Methylation IEDB 31844290
S138 Phosphorylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus   UniProt 19608861
K142 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
S185 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11004567, 15637053
S185 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 11004567, 15637053
K194 Ubiquitination PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
C404 S-Nitrosylation dbSNO 22178444
T412 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
R438 Methylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus   UniProt 23186163
K466 Acetylation PhosphoSitePlus
K466 Sumoylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T109 Phosphorylation HPRD 18669648, 19664994, 20068231
S185 Phosphorylation HPRD 11004567, 15637053
S185 Phosphorylation P68400 (CSNK2A1) HPRD 11004567, 15637053
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R66 Q66 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K73 R73 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
N86 H86 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
N86 S86 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y92 C92 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R106 W106 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S107 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K116 N116 Biomuta DOID:1324 / lung cancer [ cosmic ]
K130 E130 Biomuta DOID:363 / uterine cancer [ icgc ]
S131 Y131 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K147 N147 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S160 F160 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S176 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S185 F185 Biomuta DOID:4159 / skin cancer [ cosmic ]
K194 Q194 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K211 M211 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K211 N211 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K211 E211 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K226 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K234 N234 Biomuta DOID:3571 / liver cancer [ cosmic ]
S237 F237 Biomuta DOID:4159 / skin cancer [ cosmic ]
S247 C247 Biomuta DOID:1324 / lung cancer [ cosmic ]
T250 A250 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S441 L441 Biomuta DOID:4159 / skin cancer [ cosmic ]