Protein Information

Cytoscape View


UniProt AC / UniProt ID P06730 / IF4E_HUMAN
Protein Name Eukaryotic translation initiation factor 4E
Gene Name Name: EIF4E
Synonyms:EIF4EL1,EIF4F;
Organism Homo sapiens (Human)

PRO ID PR:P06730
DAG View
PRO Name eukaryotic translation initiation factor 4E (human)
Definition A eukaryotic translation initiation factor 4E that is encoded in the genome of human.
Short Label hEIF4E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06730 (EIF4E) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
T3 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus   UniProt 23186163
S24 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S53 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 1587843, 8505316, 3112145, ...2122455, 7590282
K54 Ubiquitination PhosphoSitePlus
S64 Phosphorylation RLIMS-P 23940704
K119 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
R173 Methylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   RLIMS-P 15248766
S209 Phosphorylation Q9HBH9 (MKNK2) , Q9BUB5 (MKNK1) , O00443 (PIK3C2A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 25193863, 9642105, 26041884, ...19934253, 20823271, 12890645, 28417568, 31398271, 20686366, 11723111, 25403230, 25915158, 31258849, 28674170, 29269484, 15122903, 30388805, 7665584, 17130135, 20664001, 30739792, 26882068, 10891393, 28745319, 7782349, 23359369, 20722422, 28386346, 17724079, 11606200, 26097864, 11112322, 12554876, 7782323, 11154262, 24551240, 28074025, 11463832, 15248766, 17590453, 16540463, 26317997, 9878069, 25561727, 21233335, 25277198, 21635931, 30804329, 19714237, 12423333, 26861281, 26268528, 20927323, 15574771, 25535978, 18365020, 28881582, 21837706, 21949767, 8662663, 29683667, 22392765, 24504069, 28864377, 12691746, 10022874, 27462781, 27926520, 29581834, 31118010, 31327462, 23824493
T210 Phosphorylation O00443 (PIK3C2A) PhosphoSitePlus   RLIMS-P+ 7782349
T211 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 19664995
T22 Phosphorylation HPRD 19651622
S53 Phosphorylation HPRD 3112145
S209 Phosphorylation P05129 (PRKCG) , P17252 (PRKCA) , Q9HBH9 (MKNK2) , P05771 (PRKCB) , Q9BUB5 (MKNK1) HPRD 12897141, 8662663, 9878069, ...9155017


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06730 (EIF4E) S209 P06730 (EIF4E) inhibited_association eFIP 31118010
Phosphorylation Q13541 (EIF4EBP1) S65 P06730 (EIF4E) increased_association eFIP 31138781
Phosphorylation Q13541 (EIF4EBP1) T70 P06730 (EIF4E) inhibited_association eFIP 31201269
Phosphorylation Q13541 (EIF4EBP1) T36 P06730 (EIF4E) inhibited_association eFIP 10405182
Phosphorylation Q13541 (EIF4EBP1) T37 P06730 (EIF4E) inhibited_association eFIP 24358826
Phosphorylation Q13542 (EIF4EBP2) T37 P06730 (EIF4E) decreased_association eFIP 25822952


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 P2 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T3 A3 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T22 M22 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S24 C24 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R173 T173 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R173 K173 Biomuta DOID:5041 / esophageal cancer [ tcga ]