Protein Information

Cytoscape View


UniProt AC / UniProt ID P06681 / CO2_HUMAN
Protein Name Complement C2 precursor
Gene Name Name: C2
Organism Homo sapiens (Human)

PRO ID PR:P06681
DAG View
PRO Name complement C2 (human)
Definition A complement C2 that is encoded in the genome of human.
Short Label hC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06681 (C2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N112 N-Glycosylation UniProt 16335952, 19159218
S178 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S266 Phosphorylation RLIMS-P 28143980
N333 N-Glycosylation UniProt 16335952, 17027507, 19159218
T361 Phosphorylation PhosphoSitePlus
N467 N-Glycosylation UniProt 16335952, 17027507
N471 N-Glycosylation UniProt 16335952
S612 Phosphorylation PhosphoSitePlus
N621 N-Glycosylation UniProt 16335952, 17027507
N651 N-Glycosylation UniProt 16335952
T660 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
T668 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T111 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S186 F186 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S266 L266 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1324 / lung cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
N471 I471 Biomuta DOID:1909 / melanoma [ tcga ]
N621 H621 Biomuta DOID:363 / uterine cancer [ tcga ]