iPTMnet Report for P06454 (PTMA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06454 / PTMA_HUMAN
Protein Name Prothymosin alpha
Gene Name Name: PTMA
Synonyms:TMSA;
Organism Homo sapiens (Human)

PRO ID PR:P06454
DAG View
PRO Name prothymosin alpha (human)
Definition A prothymosin alpha that is encoded in the genome of human.
Short Label hPTMA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06454 (PTMA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
S2 Acetylation UniProt 19413330, 19369195, 21406692, ...22223895, 22814378, 22115779, 8485135, 20068231
S2 O-Glycosylation GlyGen 32938750
S2 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 9099694, 21406692, 23186163, ...17081983, 19369195, 8485135, 19690332, 20068231
T8 Phosphorylation phospho.ELM   PhosphoSitePlus 9099694, 1426245
S9 Phosphorylation PhosphoSitePlus   UniProt 20068231
S10 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T13 Phosphorylation phospho.ELM   PhosphoSitePlus 9099694
T14 Phosphorylation phospho.ELM 9099694
K15 Acetylation PhosphoSitePlus   UniProt 19608861
K15 Ubiquitination PhosphoSitePlus
K18 Acetylation PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
R90 Methylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus   UniProt 19690332
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330, 19651622, 20068231, ...9099694
T8 Phosphorylation HPRD 19651622, 9099694, 1426245, ...20068231
S9 Phosphorylation HPRD 19413330, 19651622, 20068231
S10 Phosphorylation HPRD 19413330, 19651622, 20068231
T13 Phosphorylation HPRD 9099694
T14 Phosphorylation HPRD 9099694
T102 Phosphorylation HPRD 18669648
T107 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330, 19651622, 8485135, ...20068231, 9099694
T8 Phosphorylation HPRD 19651622, 9099694, 1426245, ...20068231
S9 Phosphorylation HPRD 19413330, 19651622, 20068231
S10 Phosphorylation HPRD 19413330, 19651622, 20068231
T13 Phosphorylation HPRD 9099694
T14 Phosphorylation HPRD 9099694
K18 Acetylation PhosphoSitePlus
T86 Phosphorylation HPRD 18669648
T101 Phosphorylation HPRD 18669648
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
T106 Phosphorylation HPRD   PhosphoSitePlus 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 G9 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K102 Q102 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2998 / testicular cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K102 N102 Biomuta DOID:363 / uterine cancer [ icgc ]
K103 Q103 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2998 / testicular cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K103 N103 Biomuta DOID:363 / uterine cancer [ icgc ]
T106 I106 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ]
T107 I107 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]