Protein Information

Cytoscape View


UniProt AC / UniProt ID P06400 / RB_HUMAN
Protein Name Retinoblastoma-associated protein
Gene Name Name: RB1
Organism Homo sapiens (Human)

PRO ID PR:P06400
DAG View
PRO Name retinoblastoma-associated protein (human)
Definition A retinoblastoma-associated protein that is encoded in the genome of human.
Short Label hRB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06400 (RB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
T5 Phosphorylation P11802 (CDK4) HPRD   neXtProt   PhosphoSitePlus 9139732, 22094256
S37 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19415658, 18669648, 24275569, ...19690332, 20068231
T140 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S230 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 10207050
Y239 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S249 Phosphorylation P24941 (CDK2) , P11802 (CDK4) , P05771 (PRKCB) , P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21368870, 22279936, 9139732, ...21406692, 23186163, 15809340, 1756735, 23304241, 19690332, 10499802, 18220336, 27419601, 20058876, 24815188, 19651622, 15355984, 22094256, 19664994, 19664995, 18669648, 11805327, 9190208, 8626527, 20068231
T252 Phosphorylation P06493 (CDK1) , P05771 (PRKCB) , P24941 (CDK2) , P11802 (CDK4) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22094256, 10499802, 23186163, ...18220336, 27419601, 21368870, 1756735, 24815188, 22279936, 18669648, 11805327, 23304241, 15355984, 9139732, 9190208, 8626527, 20068231
K265 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
T353 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648
T356 Phosphorylation P24941 (CDK2) , P11802 (CDK4) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22094256, 10499802, 23186163, ...26265441, 18220336, 23304241, 1756735, 24466208, 18669648, 11811968, 9139732, 9190208, 8626527
S360 Phosphorylation PhosphoSitePlus
T373 Phosphorylation P06493 (CDK1) , P24941 (CDK2) , P11802 (CDK4) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22094256, 10499802, 23186163, ...15567975, 18220336, 27419601, 8626527, 26159177, 1756735, 16880741, 19651622, 19690332, 22661226, 9139732, 9190208, 12490153
K427 Acetylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
K548 Acetylation PhosphoSitePlus
S567 Phosphorylation Q16539 (MAPK14) , P24941 (CDK2) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10499802, 9190208, 10207050, ...1756735, 8626527, 22279936, 27458253, 20871633
K574 Ubiquitination PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
T601 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y606 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S608 Phosphorylation P24941 (CDK2) , P11802 (CDK4) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P 10499802, 10207050, 27419601, ...9010227, 1756735, 27789274, 8626527, 12895470, 22322860, 22661226, 23304241, 9190208, 15081408, 20068231
S612 Phosphorylation O96017 (CHEK2) , O14757 (CHEK1) , Q00534 (CDK6) , P11802 (CDK4) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 1756735, 10499802, 16107892, ...10207050, 18669648, 11416152, 24466208, 16936279, 17380128, 22322860, 11811968, 23437375, 22682621, 9190208, 8626527, 20068231, 16360038
S618 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus   UniProt 23186163
T625 Phosphorylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K720 Sumoylation PhosphoSitePlus
Y771 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
R775 Methylation PhosphoSitePlus
T778 Phosphorylation PhosphoSitePlus
S780 Phosphorylation P11802 (CDK4) , P30279 (CCND2) , P17612 (PRKACA) , Q00534 (CDK6) , Q96GD4 (AURKB) , P05771 (PRKCB) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15489884, 21270107, 26203195, ...16936279, 24169358, 11811957, 19551155, 24463355, 23505430, 16360038, 25737734, 23186163, 15809340, 18383818, 11306463, 24454925, 15817163, 17621266, 15547725, 27419601, 26159177, 11416152, 14732295, 19651622, 10086343, 11811968, 22682621, 15548374, 19225156, 10022898, 11254678, 22493456, 23336272, 16236452, 23622063, 24466208, 9003781, 11805327, 17478427, 20372067, 15941859, 19135778, 16326706, 28105458
R787 Methylation PhosphoSitePlus
S788 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) HPRD   neXtProt   PhosphoSitePlus   UniProt 22094256, 23186163, 19664994, ...11416152, 19651622, 16936279, 22682621, 9139732, 9190208, 16360038
Y790 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
S795 Phosphorylation P05771 (PRKCB) , P11802 (CDK4) , P50750 (CDK9) , Q00534 (CDK6) , Q00535 (CDK5) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16718685, 27862183, 26250117, ...16936279, 15741232, 17896003, 9139732, 24463355, 16360038, 23186163, 15809340, 18383818, 21478909, 15138593, 11306463, 27419601, 10069453, 15817163, 12490153, 15172998, 26106036, 15547725, 17976389, 26159177, 12037672, 11416152, 14732295, 10210318, 22682621, 22094256, 15567975, 23336272, 12754735, 19664994, 11805327, 15941859, 9190208, 22450712
R798 Methylation PhosphoSitePlus
Y805 Phosphorylation P00519 (ABL1) PhosphoSitePlus   Signor 16158058
S807 Phosphorylation P06493 (CDK1) , P24941 (CDK2) , P50750 (CDK9) , Q00534 (CDK6) , P11802 (CDK4) , Q00526 (CDK3) , Q00535 (CDK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 1756735, 18938028, 16936279, ...10499802, 16360038, 15741232, 21115810, 9139732, 24463355, 20703084, 25522274, 23186163, 15809340, 18383818, 24274149, 11306463, 25695870, 17568194, 19690332, 15084261, 12037672, 28169375, 20058876, 11416152, 14732295, 15194426, 22682621, 15548374, 19651622, 22094256, 16236452, 23622063, 18669648, 22787429, 15941859, 9190208, 8626527, 20068231
K810 Methylation Q9NRG4 (SMYD2) PhosphoSitePlus   UniProt 22787429
K810 Ubiquitination PhosphoSitePlus
S811 Phosphorylation Q00534 (CDK6) , P06493 (CDK1) , P24941 (CDK2) , P11802 (CDK4) , Q00526 (CDK3) , P50750 (CDK9) , Q00535 (CDK5) , Q13131 (PRKAA1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18938028, 16936279, 10499802, ...16360038, 15741232, 21115810, 9139732, 24463355, 20703084, 25522274, 23186163, 15809340, 18383818, 1756735, 11306463, 25695870, 17568194, 12037672, 15084261, 26159177, 28169375, 11416152, 14732295, 15194426, 22682621, 15548374, 19217427, 19651622, 22094256, 16236452, 23622063, 18669648, 22787429, 15941859, 9190208, 8626527, 20068231
Y813 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S816 Phosphorylation PhosphoSitePlus
T821 Phosphorylation P24941 (CDK2) , Q00534 (CDK6) , P05771 (PRKCB) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16107892, 16936279, 28105458, ...9139732, 16360038, 23186163, 15809340, 1756735, 23315497, 19413330, 10499802, 11416152, 19651622, 20010939, 9315635, 22682621, 19664994, 18669648, 11805327, 9190208, 8626527, 20068231
T823 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664994, ...19651622, 18669648, 20068231
T826 Phosphorylation Q00534 (CDK6) , P11802 (CDK4) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 1756735, 22094256, 10499802, ...23186163, 15809340, 9315635, 19664994, 25695870, 11416152, 19651622, 16936279, 18669648, 28105458, 22682621, 9139732, 9190208, 23737759, 8626527, 20068231, 16360038
S829 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
T841 Phosphorylation PhosphoSitePlus   UniProt 19690332
S842 Phosphorylation PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
S855 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R857 Methylation PhosphoSitePlus
K860 Methylation Q9NRG4 (SMYD2) UniProt 20870719
S862 Phosphorylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
K873 Acetylation PhosphoSitePlus   UniProt 20940255
K874 Acetylation PhosphoSitePlus   UniProt 20940255
S882 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
K896 Acetylation PhosphoSitePlus
T905 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
K925 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K873 Acetylation PR:000007102 (EP300) PRO 16374512
K874 Acetylation PR:000007102 (EP300) PRO 16374512


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049016 (hRB1/InitMet-/Phos:2) pS795 PRO
PR:000049017 (hRB1/InitMet-/PhosRes+) p PRO
PR:000028788 (hRB1/iso:1/Ac:1) acK873,acK874 PR:000007102 (EP300) PRO 16374512


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06400 (RB1) S811 P00519 (ABL1) unknown eFIP 21445688
Phosphorylation P06400 (RB1) S612 Q13526 (PIN1) unknown eFIP 22322860
Phosphorylation P06400 (RB1) S608 Q13526 (PIN1) unknown eFIP 22322860
Phosphorylation P06400 (RB1) S612 Q01094 (E2F1) inhibited_association eFIP 17380128
Phosphorylation P06400 (RB1) S612 Q01094 (E2F1) increased_association eFIP 17380128
Phosphorylation P06400 (RB1) S807 P00519 (ABL1) unknown eFIP 21445688
Phosphorylation Q01094 (E2F1) S332 P06400 (RB1) inhibited_association eFIP 25101673
Phosphorylation Q01094 (E2F1) S337 P06400 (RB1) increased_association eFIP 20616879
Phosphorylation Q01094 (E2F1) S332 P06400 (RB1) increased_association eFIP 20616879
Phosphorylation Q01094 (E2F1) S375 P06400 (RB1) decreased_association eFIP 20616879
Phosphorylation Q01094 (E2F1) S375 P06400 (RB1) increased_association eFIP 7824278


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P29590-3 (hPML/iso:3) Interaction PR:P06400 (hRB1) PRO 9448006
PR:P29590-5 (hPML/iso:5) Interaction PR:P06400 (hRB1) PRO 9448006