iPTMnet Report for P06280 (GLA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06280 / AGAL_HUMAN
Protein Name Alpha-galactosidase A precursor
Gene Name Name: GLA
Organism Homo sapiens (Human)

PRO ID PR:P06280
DAG View
PRO Name alpha-galactosidase A (human)
Definition An alpha-galactosidase A that is encoded in the genome of human.
Short Label hGLA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06280 (GLA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
N139 N-Glycosylation GlyGen   UniProt 15003450, 23090970, 24190977, ...9620884, 29741879
N192 N-Glycosylation GlyGen   UniProt 15003450, 23090970, 24190977, ...9620884, 29741879
N215 N-Glycosylation GlyGen   UniProt 15003450, 29741879, 19159218, ...9620884, 24190977
K237 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S371 Phosphorylation IEDB   PhosphoSitePlus 35494241
K391 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
R402 Methylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K308 R308 Biomuta DOID:184 / bone cancer [ cosmic ]
R402 M402 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]