iPTMnet Report for P06239 (LCK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06239 / LCK_HUMAN
Protein Name Tyrosine-protein kinase Lck
Gene Name Name: LCK
Organism Homo sapiens (Human)

PRO ID PR:P06239
DAG View
PRO Name tyrosine-protein kinase Lck (human)
Definition A tyrosine-protein kinase Lck that is encoded in the genome of human.
Short Label hLCK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06239 (LCK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y25 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
S42 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P17252 (PRKCA) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8226850, 8506364
T50 Phosphorylation PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
S59 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 25535246, 11847223, 23874979, ...8618896, 7597029, 33345332, 15199125, 8226850, 8506364
K84 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus   UniProt 19690332
K118 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 8262984
T159 Phosphorylation PhosphoSitePlus   UniProt 19690332
S162 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 17192257
S166 Phosphorylation Q02156 (PRKCE) neXtProt 11854322
K179 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
Y192 Phosphorylation P43405 (SYK) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 25316710, 19168706, 15659558, ...27014263, 17192257, 23874979, 18083107, 7518561, 8798764, 25492967, 7981618, 28644030
S194 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 7981618, 8262984, 19690332
T198 Phosphorylation PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
S213 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
K228 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation P06239 (LCK) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 16461343, 27547268, 15659558, ...7962172, 3265417, 11828322, 8139546, 8258691, 17192257, 23874979, 28798028, 33345332, 23071622, 27280403, 25535246, 25997448, 27841348, 26654242, 19426503, 19398758, 21152094, 26147970, 19776125, 9043947, 29073235, 27835610, 19201869, 2250907, 33374422, 20541955, 10400611, 33727792, 33420490, 27091106, 1697929, 21757751, 30356330, 10601992, 24405902, 26210498, 1639064, 29083415, 26421924, 8945479, 28970470, 8631775, 30026610, 32237064, 29456532, 15259016, 8414515, 3352600, 30220567, 8647864, 28096507, 9325251, 24694060, 7538674, 28628650, 24463463, 34414199, 29410624, 15592455, 31704808, 15827961, 10692391
T395 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
T501 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
Y505 Phosphorylation P41240 (CSK) , P06239 (LCK) , P42679 (MATK) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 27547268, 12570875, 22043010, ...3265417, 17192257, 8139546, 27280403, 17947241, 15699109, 26654242, 15743820, 18691976, 26421924, 21152094, 26147970, 24463463, 9043947, 14610046, 21042412, 27835610, 3352600, 17897955, 8197166, 21406692, 33374422, 20541955, 33727792, 33420490, 19690332, 1697929, 28628650, 30356330, 7511815, 24405902, 19369195, 7507203, 1639064, 29083415, 20035083, 8945479, 7739523, 28970470, 18541536, 8631775, 15592455, 7872793, 15259016, 8175795, 3380789, 8049439, 30220567, 24231767, 28096507, 11181701, 9325251, 7690927, 18083107, 2479826, 34414199, 28838952, 21288338
Site PTM Type PTM Enzyme Score Source PMID
S42 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 8506364
S59 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 8618896, 8506364
S133 Phosphorylation HPRD 18452278
Y192 Phosphorylation P43405 (SYK) HPRD 18083107, 19664994, 8798764, ...16497976
Y394 Phosphorylation P08637 (FCGR3A) , P06239 (LCK) HPRD   PRO 16461343, 18578522, 9043947, ...8258691, 15144186, 8405050, 8945479
Y505 Phosphorylation P41240 (CSK) HPRD   PRO 16461343, 19901323, 12485116, ...18691976, 9043947, 15144186, 16497976


P06239 (LCK) as PTM Enzyme



Substrate Site Score Source PMID
O14543 (SOCS3) Y204 phospho.ELM   PhosphoSitePlus 12783885
O14543 (SOCS3) Y221 phospho.ELM   PhosphoSitePlus 12783885, 15173187
O43561 (LAT) Y64 RLIMS-P+ 27700984
O43561 (LAT) Y200 Signor 16938345
O43561 (LAT) Y220 Signor 16938345
P03372 (ESR1) Y537 HPRD   phospho.ELM   PhosphoSitePlus   Signor 7539106, 10571988, 9500442
P05107 (ITGB2) Y735 PhosphoSitePlus 22990843
P06127 (CD5) Y453 HPRD   phospho.ELM   PhosphoSitePlus   Signor 15144186, 11298344
P06127 (CD5) Y487 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11298344
P06239-1 (LCK) Y394 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16461343, 3352600, 18578522, ...8139546, 3265417, 2250907, 11828322, 1639064, 8258691, 15144186, 8405050, 8945479
P06239 (LCK) Y505 phospho.ELM   PhosphoSitePlus 8945479
P07766 (CD3E) Y188 HPRD 11855827
P07766 (CD3E) Y199 HPRD 11855827
P10747 (CD28) Y191 neXtProt   phospho.ELM   Signor 7568038, 22936936, 8992971
P12235 (SLC25A4) Y195 PhosphoSitePlus 20007455
P14784 (IL2RB) Y381 HPRD   phospho.ELM   PhosphoSitePlus 10214954, 2047859
P14784 (IL2RB) Y384 HPRD   phospho.ELM   PhosphoSitePlus 10214954, 2047859
P14784 (IL2RB) Y387 HPRD   phospho.ELM   PhosphoSitePlus 10214954, 2047859
P14784 (IL2RB) Y418 HPRD   phospho.ELM   PhosphoSitePlus 10214954
P14784 (IL2RB) Y536 HPRD   phospho.ELM   PhosphoSitePlus 10214954
P15311 (EZR) Y146 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 1382070, 12560083
P15498 (VAV1) Y142 HPRD   phospho.ELM   PhosphoSitePlus 16285729, 10669745
P15498 (VAV1) Y160 HPRD   phospho.ELM   PhosphoSitePlus 16285729, 10669745
P15498-1 (VAV1) Y174 HPRD   PhosphoSitePlus 16285729, 10669745
P15941 (MUC1) Y1229 neXtProt   Signor 14766232
P16284 (PECAM1) Y713 PhosphoSitePlus 12207897
P16410-1 (CTLA4) Y201 HPRD   Signor 9973379
P16410 (CTLA4) Y218 Signor 9973379
P16885 (PLCG2) Y743 phospho.ELM 12181444
P16885 (PLCG2) Y753 HPRD   phospho.ELM   PhosphoSitePlus   Signor 7682059, 11606584, 12181444, ...15144186, 15184383
P16885 (PLCG2) Y759 HPRD   phospho.ELM   PhosphoSitePlus   Signor 19901323, 15184383, 7682059, ...11606584, 12181444, 16497976
P16885 (PLCG2) Y1197 phospho.ELM   PhosphoSitePlus 15184383
P16885 (PLCG2) Y1217 phospho.ELM   PhosphoSitePlus 15184383
P20138 (CD33) Y340 phospho.ELM   PhosphoSitePlus   Signor 10887109
P20936-2 (RASA1) Y283 HPRD 1850098
P20936-1 (RASA1) Y460 HPRD 1850098
P20963 (CD247) Y142 PhosphoSitePlus 20541955
P22681 (CBL) Y700 PhosphoSitePlus 9525940
P22681 (CBL) Y731 PhosphoSitePlus 9525940
P22681 (CBL) Y774 PhosphoSitePlus 9525940
P23743 (DGKA) Y335 PhosphoSitePlus 18424699
P24666 (ACP1) Y132 HPRD   PhosphoSitePlus 17016520, 9038134
P24666 (ACP1) Y133 HPRD   PhosphoSitePlus 9038134
P25963 (NFKBIA) Y42 HPRD   phospho.ELM   PhosphoSitePlus 8797825, 12429743, 9792645
P27361 (MAPK3) Y204 Signor 17998336
P27986-3 (PIK3R1) Y388 HPRD 9461588
P27986-2 (PIK3R1) Y418 HPRD 9461588
P27986-1 (PIK3R1) Y688 HPRD 9461588
P29350 (PTPN6) Y536 HPRD   phospho.ELM   PhosphoSitePlus 7512963, 8114715, 16497976
P29350-3 (PTPN6) Y538 HPRD 8114715, 16497976
P29350 (PTPN6) Y564 HPRD   phospho.ELM   PhosphoSitePlus   Signor 16649996, 10488096, 8114715
P29350-3 (PTPN6) Y566 HPRD 8114715
P29353-2 (SHC1) Y239 PhosphoSitePlus 17537990
P29353-2 (SHC1) Y240 PhosphoSitePlus 17537990
P29353-2 (SHC1) Y317 PhosphoSitePlus 9710204, 17537990
P29353-7 (SHC1) Y318 HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P29353 (SHC1) Y427 HPRD   Signor 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P40259-2 (CD79B) Y92 HPRD 8077654
P40259-2 (CD79B) Y103 HPRD 8077654
P40259-1 (CD79B) Y196 HPRD 8077654
P40259-1 (CD79B) Y207 HPRD 8077654
P42224-1 (STAT1) Y701 HPRD 10918587, 7657660, 15322115, ...7543024, 11839738, 12817007, 7690989, 11294897, 12637327
P42229 (STAT5A) Y694 PhosphoSitePlus 10849428
P42768 (WAS) Y291 PhosphoSitePlus 12769846
P43403-2 (ZAP70) Y12 HPRD 10318843
P43403-1 (ZAP70) Y69 HPRD   PhosphoSitePlus   Signor 7961936
P43403 (ZAP70) Y126 PhosphoSitePlus 7961936
P43403-2 (ZAP70) Y167 HPRD 7961936, 9685404
P43403 (ZAP70) Y178 HPRD   PhosphoSitePlus   Signor 7961936
P43403-2 (ZAP70) Y185 HPRD 7961936
P43403-2 (ZAP70) Y186 HPRD 7961936, 15144186
P43403 (ZAP70) Y292 phospho.ELM   PhosphoSitePlus 8756661, 26237552, 7961936
P43403 (ZAP70) Y315 PhosphoSitePlus 26237552
P43403 (ZAP70) Y319 HPRD   neXtProt   PhosphoSitePlus 10318843, 10202147, 26237552
P43403 (ZAP70) Y474 HPRD   phospho.ELM   PhosphoSitePlus   Signor 7961936, 9685404
P43403-1 (ZAP70) Y492 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7961936, 8756661, 7642520, ...7781602, 11270871, 26237552
P43403 (ZAP70) Y493 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7961936, 15144186, 8756661, ...7642520, 7781602, 11270871, 26237552
P52630 (STAT2) Y690 PhosphoSitePlus 8197134
P52735 (VAV2) Y142 phospho.ELM 12454019
P52735 (VAV2) Y159 phospho.ELM 12454019
P52735 (VAV2) Y172 phospho.ELM 12454019
P52757 (CHN2) Y153 PhosphoSitePlus 19201754
P60484 (PTEN) Y240 phospho.ELM   PhosphoSitePlus 11948419
P60484 (PTEN) Y315 phospho.ELM   PhosphoSitePlus   Signor 11948419
P67775 (PPP2CA) Y307 PhosphoSitePlus 1325671
Q04759 (PRKCQ) Y90 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10652356
Q05655 (PRKCD) Y313 HPRD   neXtProt 17016520, 18691976, 17389395, ...11381116, 16497976
Q05655-1 (PRKCD) Y334 HPRD 18691976, 11381116
Q05655-1 (PRKCD) Y514 HPRD 11381116
Q06830 (PRDX1) Y194 PhosphoSitePlus 20178744
Q08881 (ITK) Y512 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 12842872, 9312162, 15144186
Q13094 (LCP2) Y113 phospho.ELM   PhosphoSitePlus 8702662
Q13094 (LCP2) Y128 phospho.ELM   PhosphoSitePlus 8702662
Q13094 (LCP2) Y145 PhosphoSitePlus 8702662
Q13094 (LCP2) Y423 HPRD 8702662
Q13094 (LCP2) Y426 HPRD 8702662
Q13283 (G3BP1) Y56 PhosphoSitePlus 15743820
Q13291 (SLAMF1) Y307 phospho.ELM   PhosphoSitePlus 11806999
Q13444 (ADAM15) Y715 PhosphoSitePlus   Signor 11741929
Q13444 (ADAM15) Y735 Signor 11741929
Q13813 (SPTAN1) Y1176 phospho.ELM 11971983
Q15831 (STK11) Y36 neXtProt 21487392
Q15831 (STK11) Y261 neXtProt 21487392
Q15831 (STK11) Y362 neXtProt 21487392
Q16539 (MAPK14) Y323 neXtProt   PhosphoSitePlus 15735648
Q8IVM0 (CCDC50) Y217 PhosphoSitePlus   Signor 19059208
Q8IVM0 (CCDC50) Y279 PhosphoSitePlus   Signor 19059208
Q8IVM0 (CCDC50) Y304 PhosphoSitePlus   Signor 19059208
Q8IWV1 (LAX1) Y193 Signor 12359715
Q8IWV1 (LAX1) Y268 Signor 12359715
Q8IWV1 (LAX1) Y294 Signor 12359715
Q8IWV1 (LAX1) Y373 Signor 12359715
Q8N1K5 (THEMIS) Y540 PhosphoSitePlus 23460737
Q8N1K5 (THEMIS) Y541 PhosphoSitePlus 23460737
Q96LC7 (SIGLEC10) Y597 phospho.ELM   PhosphoSitePlus   Signor 11733002
Q96LC7 (SIGLEC10) Y667 phospho.ELM   PhosphoSitePlus   Signor 11733002
Q96LC7 (SIGLEC10) Y691 phospho.ELM   PhosphoSitePlus   Signor 11733002
Q99704-1 (DOK1) Y174 HPRD 10799545
Q9BWW4 (SSBP3) Y23 PhosphoSitePlus 18080319
Q9BWW4 (SSBP3) Y25 PhosphoSitePlus 18080319
Q9BZS1 (FOXP3) Y342 PhosphoSitePlus   Signor 24155921
Q9H204 (MED28) Y64 HPRD   neXtProt   PhosphoSitePlus   Signor 16899217
Q9H4E7 (DEF6) Y133 Signor 18976935
Q9H4E7 (DEF6) Y144 Signor 18976935
Q9H4E7 (DEF6) Y210 HPRD 12923183
Q9NP31 (SH2D2A) Y260 PhosphoSitePlus 18541536
Q9NP31 (SH2D2A) Y280 neXtProt   PhosphoSitePlus   Signor 18541536
Q9NP31 (SH2D2A) Y290 neXtProt   PhosphoSitePlus   Signor 18541536
Q9NP31 (SH2D2A) Y305 neXtProt   PhosphoSitePlus   Signor 18541536
Q9UN19 (DAPP1) Y139 HPRD   phospho.ELM   PhosphoSitePlus 19901323, 10880360, 17389395
Q9UQQ2 (SH2B3) Y273 HPRD   phospho.ELM   Signor 9169414


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048171 (hLCK/Phos:2) pY394 PRO
PR:000048172 (hLCK/Phos:3) pY505 PRO
PR:000036619 (hLCK/iso:1/Phos:1) pY394,pY505 PRO 9043947
PR:000036622 (hLCK/iso:1/Phos:2) pY394 PRO 9043947


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06239 (LCK) S59 P29350 (PTPN6) inhibited_association eFIP 29187853
Phosphorylation P06239 (LCK) Y192 Q9NP31 (SH2D2A) unknown eFIP 27014263
Phosphorylation P06239 (LCK) S59 P37198 (NUP62) inhibited_association eFIP 8618896
Phosphorylation P43403 (ZAP70) Y319 P06239 (LCK) unknown eFIP 10318843


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036622 (hLCK/iso:1/Phos:2) Interaction PRO 9043947


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T35 M35 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K84 R84 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y181 S181 Biomuta DOID:363 / uterine cancer [ cosmic ]
K246 N246 Biomuta DOID:184 / bone cancer [ cosmic ]
Y264 S264 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y264 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T268 M268 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K269 E269 Biomuta DOID:4159 / skin cancer [ cosmic ]
S274 N274 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S281 F281 Biomuta DOID:4159 / skin cancer [ cosmic ]
K379 E379 Biomuta DOID:1612 / breast cancer [ cosmic ]
T416 I416 Biomuta DOID:363 / uterine cancer [ cosmic ]