Protein Information

Cytoscape View


UniProt AC / UniProt ID P06213 / INSR_HUMAN
Protein Name Insulin receptor precursor
Gene Name Name: INSR
Organism Homo sapiens (Human)

PRO ID PR:P06213
DAG View
PRO Name insulin receptor (human)
Definition An insulin receptor that is encoded in the genome of human.
Short Label hINSR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06213 (INSR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N43 N-Glycosylation UniProt 16894147, 23302862, 2983222
N52 N-Glycosylation UniProt 16894147, 23302862
T68 Phosphorylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
N138 N-Glycosylation UniProt 16894147, 23302862
N242 N-Glycosylation UniProt 16894147, 23302862, 19159218
N282 N-Glycosylation UniProt 16894147, 23302862
T361 Phosphorylation PhosphoSitePlus
N364 N-Glycosylation UniProt 16894147
S366 Phosphorylation PhosphoSitePlus
S400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y401 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
N424 N-Glycosylation UniProt 16894147
N445 N-Glycosylation UniProt 16894147, 19349973
T447 Phosphorylation PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S473 Phosphorylation RLIMS-P 26245346, 15010337
N541 N-Glycosylation UniProt 1472036, 19159218
S567 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
T715 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
T731 Phosphorylation PhosphoSitePlus
N769 N-Glycosylation UniProt 2983222
Y818 Phosphorylation PhosphoSitePlus
N920 N-Glycosylation UniProt 19349973
S929 Phosphorylation PhosphoSitePlus
T940 Phosphorylation PhosphoSitePlus
Y992 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 1658004, 3166375, 8024702
Y999 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus   UniProt 10852715, 8393870, 1658004, ...8662806, 3166375, 10340378
Y1011 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 3166375, 12707268
K1022 Ubiquitination PhosphoSitePlus
S1033 Phosphorylation Q9UHD2 (TBK1) neXtProt   PhosphoSitePlus 19251743
Y1038 Phosphorylation PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
S1062 Phosphorylation P17252 (PRKCA) neXtProt   phospho.ELM   PhosphoSitePlus 7926007
S1064 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus 7926007
C1083 S-Nitrosylation dbSNO 22178444, 11225731
K1112 Acetylation PhosphoSitePlus
Y1149 Phosphorylation PhosphoSitePlus
C1165 S-Nitrosylation dbSNO 22178444, 11225731
Y1185 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24296476, 3038872, 1658004, ...14690593, 9312016, 16271887, 7806540, 10940390, 10463939, 1645354, 9000514, 11401470, 16246733, 10852715, 8024702, 1689998, 18278056, 18767165, 18083107, 3166375, 1321605, 15135305
T1187 Phosphorylation PhosphoSitePlus
Y1189 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 3038872, 9506989, 1658004, ...14690593, 9312016, 16271887, 7806540, 10940390, 10463939, 1645354, 9000514, 11401470, 16246733, 10852715, 8024702, 1689998, 18278056, 18767165, 18083107, 3166375, 1321605, 15135305
Y1190 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 3038872, 9506989, 1658004, ...14690593, 9312016, 16271887, 7806540, 10940390, 1645354, 9000514, 11401470, 16246733, 10852715, 8024702, 1689998, 18278056, 18767165, 18083107, 3166375, 1321605, 15135305
K1192 Ubiquitination PhosphoSitePlus
K1195 Ubiquitination PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus
C1261 S-Nitrosylation dbSNO 22178444, 11225731
C1272 S-Nitrosylation dbSNO 22178444, 11225731
S1314 Phosphorylation P06213 (INSR) neXtProt   PhosphoSitePlus 10852715, 11401470, 9000514
S1332 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus 2136851
S1333 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus 2136851
S1348 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus 11401470, 9000514, 10940390, ...10852715
K1352 Methylation PhosphoSitePlus
K1352 Ubiquitination PhosphoSitePlus
S1354 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 1321605, 7929343
Y1355 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 1658004, 1689998, 10852715, ...3038872, 9000514, 3166375, 11401470, 1321605, 10940390
Y1361 Phosphorylation P06213 (INSR) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10852715, 1689998, 1658004, ...3038872, 9000514, 3166375, 11401470, 1321605, 10940390
T1362 Phosphorylation PhosphoSitePlus
T1375 Phosphorylation phospho.ELM   PhosphoSitePlus 8454604, 2110001, 1956339
Site PTM Type PTM Enzyme Score Source PMID
S400 Phosphorylation HPRD 18669648
Y401 Phosphorylation HPRD 18669648
S407 Phosphorylation HPRD 18669648
Y992 Phosphorylation P06213 (INSR) HPRD 8504096
Y999 Phosphorylation P06213 (INSR) HPRD 8496180
S1062 Phosphorylation P17252 (PRKCA) HPRD 7926007
S1064 Phosphorylation P17252 (PRKCA) HPRD 7926007
Y1185 Phosphorylation P06213 (INSR) HPRD 16497976, 7806540
Y1189 Phosphorylation P06213 (INSR) HPRD 19901323, 16497976, 7806540
Y1190 Phosphorylation P06213 (INSR) HPRD 19901323, 16497976, 7806540
S1314 Phosphorylation HPRD 11401470
S1348 Phosphorylation HPRD 11401470
S1354 Phosphorylation HPRD 18691976, 7929343
Y1355 Phosphorylation P06213 (INSR) HPRD 11401470, 19901323
Y1361 Phosphorylation P06213 (INSR) HPRD 11401470, 19901323
T1362 Phosphorylation P17252 (PRKCA) HPRD 8463287
T1375 Phosphorylation HPRD 1956339
Site PTM Type PTM Enzyme Score Source PMID
S400 Phosphorylation HPRD 18669648
Y401 Phosphorylation HPRD 18669648
S407 Phosphorylation HPRD 18669648
Y987 Phosphorylation HPRD   PhosphoSitePlus 16582879
S989 Phosphorylation PhosphoSitePlus
Y1173 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 15951569, 11401470, 16497976
Y1177 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 19901323, 15951569, 11401470, ...16497976
Y1178 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 19901323, 11401470, 16497976
S1302 Phosphorylation P06213 (INSR) PhosphoSitePlus 11401470
S1336 Phosphorylation P06213 (INSR) PhosphoSitePlus 11401470
S1342 Phosphorylation HPRD 18691976
Y1343 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 19901323, 11401470
Y1349 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 19901323, 11401470
T1363 Phosphorylation PhosphoSitePlus


P06213 (INSR) as PTM Enzyme



Substrate Site Score Source PMID
P06213 (INSR) Y992 HPRD   phospho.ELM   PhosphoSitePlus 1658004, 3166375, 8024702, ...8504096
P06213 (INSR) Y999 HPRD   phospho.ELM   PhosphoSitePlus   UniProt 10852715, 1658004, 8662806, ...8496180, 10340378, 3166375
P06213 (INSR) Y1011 phospho.ELM   PhosphoSitePlus 3166375, 12707268
P06213-2 (INSR) Y1173 PhosphoSitePlus 11401470
P06213-2 (INSR) Y1177 PhosphoSitePlus 11401470
P06213-2 (INSR) Y1178 PhosphoSitePlus 11401470
P06213 (INSR) Y1185 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10852715, 8024702, 1689998, ...10463939, 1658004, 3038872, 14690593, 1645354, 9000514, 3166375, 7806540, 11401470, 1321605, 15135305, 10940390, 16497976
P06213 (INSR) Y1189 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 10852715, 8024702, ...1689998, 10463939, 1658004, 3038872, 14690593, 1645354, 9000514, 3166375, 7806540, 11401470, 1321605, 15135305, 10940390, 16497976
P06213 (INSR) Y1190 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 1658004, 8024702, ...1689998, 10852715, 3038872, 14690593, 1645354, 9000514, 3166375, 7806540, 11401470, 1321605, 16497976, 10940390, 15135305
P06213-2 (INSR) S1302 PhosphoSitePlus 11401470
P06213 (INSR) S1314 neXtProt   PhosphoSitePlus 11401470, 10852715, 9000514
P06213 (INSR) S1332 neXtProt 2136851
P06213 (INSR) S1333 neXtProt 2136851
P06213-2 (INSR) S1336 PhosphoSitePlus 11401470
P06213-2 (INSR) Y1343 PhosphoSitePlus 11401470
P06213 (INSR) S1348 neXtProt   PhosphoSitePlus 11401470, 10852715, 9000514
P06213-2 (INSR) Y1349 PhosphoSitePlus 11401470
P06213 (INSR) Y1355 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 1658004, 1689998, ...10852715, 3038872, 9000514, 3166375, 11401470, 1321605, 10940390
P06213 (INSR) Y1361 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 10852715, 1689998, ...1658004, 3038872, 9000514, 3166375, 11401470, 1321605, 10940390
P07550 (ADRB2) Y132 HPRD 8557631
P07550 (ADRB2) Y141 HPRD 8557631
P07550 (ADRB2) Y350 HPRD 8557631
P07550 (ADRB2) Y354 HPRD 8557631
P0DP23 (CALM1) Y100 HPRD 17016520, 19901323, 18578522, ...17389395, 17287340, 18669648, 18707149, 12153558, 20068231, 16497976
P0DP23 (CALM1) Y139 HPRD 8639568
P15090 (FABP4) Y20 HPRD 8463311, 1648089
P18031 (PTPN1) Y66 HPRD 11506178, 9355745
P18031 (PTPN1) Y152 HPRD   phospho.ELM 11106648, 11506178
P18031 (PTPN1) Y153 HPRD   phospho.ELM 11106648, 11506178
P22681 (CBL) Y371 HPRD   phospho.ELM 11997497, 10635327
P22681 (CBL) Y700 phospho.ELM 11997497
P25963 (NFKBIA) Y42 PhosphoSitePlus 8797825
P27986-3 (PIK3R1) Y68 HPRD 8385099, 14729945
P27986-2 (PIK3R1) Y98 HPRD 8385099, 14729945
P27986-3 (PIK3R1) Y280 HPRD 17016520, 8385099, 16497976
P27986-3 (PIK3R1) Y307 HPRD 17016520, 17389395, 8385099, ...20068231
P27986-2 (PIK3R1) Y310 HPRD 17016520, 8385099, 16497976
P27986-2 (PIK3R1) Y337 HPRD 17016520, 17389395, 8385099, ...20068231
P27986 (PIK3R1) Y368 HPRD   phospho.ELM   PhosphoSitePlus 8385099, 14729945
P27986 (PIK3R1) Y580 HPRD   phospho.ELM   PhosphoSitePlus 17016520, 8385099, 16497976
P27986 (PIK3R1) Y607 HPRD   phospho.ELM   PhosphoSitePlus 17016520, 17389395, 8385099, ...20068231
P29350-1 (PTPN6) Y536 HPRD   neXtProt   PhosphoSitePlus   Signor 7512963, 16497976
P29350-3 (PTPN6) Y538 HPRD 8114715, 16497976
P29353-7 (SHC1) Y318 HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P29353-1 (SHC1) Y427 HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P35232 (PHB) Y114 PhosphoSitePlus 19497338
P35568 (IRS1) Y896 PhosphoSitePlus   Signor 12220227, 8530377
P35568 (IRS1) Y989 PhosphoSitePlus 8530377
P35568 (IRS1) Y1179 PhosphoSitePlus 8530377
P35568 (IRS1) Y1229 Signor 12220227
P42229 (STAT5A) Y694 neXtProt 12456798
P51692 (STAT5B) Y699 neXtProt 12456798, 9428692
P53004 (BLVRA) Y198 phospho.ELM   PhosphoSitePlus 15870194
P53004 (BLVRA) Y228 phospho.ELM   PhosphoSitePlus 15870194
P53004 (BLVRA) Y291 phospho.ELM   PhosphoSitePlus 15870194
P60484 (PTEN) Y27 PhosphoSitePlus 23995781
P60484 (PTEN) Y174 PhosphoSitePlus 23995781
P67775 (PPP2CA) Y307 PhosphoSitePlus 1325671
Q05397-1 (PTK2) Y576 HPRD 17016520, 9507031, 17389395, ...19664994, 7529876, 20068231
Q05397-1 (PTK2) Y577 HPRD 9507031, 7529876, 20068231
Q13017 (ARHGAP5) Y306 PhosphoSitePlus 12705864
Q13480 (GAB1) Y242 HPRD   phospho.ELM   PhosphoSitePlus 10978177, 16497976
Q13480-1 (GAB1) Y285 HPRD   PhosphoSitePlus 10978177
Q13480 (GAB1) Y373 HPRD   phospho.ELM   PhosphoSitePlus 10978177, 17389395, 16497976
Q13480 (GAB1) Y447 HPRD   phospho.ELM   PhosphoSitePlus 10978177, 9658397
Q13480-1 (GAB1) Y472 HPRD   phospho.ELM   PhosphoSitePlus 10978177, 9658397
Q13480-1 (GAB1) Y589 HPRD   phospho.ELM   PhosphoSitePlus 10978177, 9658397
Q13480-2 (GAB1) Y619 HPRD 10978177
Q13480 (GAB1) Y627 HPRD   phospho.ELM   PhosphoSitePlus 10978177, 17016520, 17389395, ...9658397, 10734310, 20068231
Q13480-2 (GAB1) Y657 HPRD 17016520, 10734310, 17389395, ...20068231
Q13480-1 (GAB1) Y659 HPRD   PhosphoSitePlus 10978177, 10734310, 18669648, ...17389395, 16497976
Q13480-2 (GAB1) Y689 HPRD 10734310, 18669648, 17389395, ...16497976
Q658W2 (DKFZp666O0110) Y598 HPRD 17016520, 9507031, 17389395, ...19664994, 7529876, 20068231
Q658W2 (DKFZp666O0110) Y599 HPRD 9507031, 7529876, 20068231
Q92569 (PIK3R3) Y341 PhosphoSitePlus   Signor 7542745
Q99704 (DOK1) Y362 HPRD   phospho.ELM   PhosphoSitePlus 11551902, 16497976
Q99704 (DOK1) Y398 HPRD   phospho.ELM   PhosphoSitePlus 19901323, 11551902, 16497976
Q9Y4H2 (IRS2) Y628 HPRD 9195949
Q9Y4H2 (IRS2) Y632 HPRD 19901323, 9195949


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T68 K68 Biomuta DOID:3571 / liver cancer [ icgc ]
S400 C400 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y401 F401 Biomuta DOID:1324 / lung cancer [ tcga ]
S407 F407 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y457 C457 Biomuta DOID:1324 / lung cancer [ cosmic ]
S473 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S682 L682 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T731 M731 Biomuta DOID:1909 / melanoma [ cosmic ]
K1047 M1047 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S1062 P1062 Biomuta DOID:363 / uterine cancer [ tcga ]
T1187 M1187 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1216 F1216 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1221 A1221 Biomuta DOID:4159 / skin cancer [ icgc ]
S1354 R1354 Biomuta DOID:1115 / sarcoma [ tcga ]
Y1361 D1361 Biomuta DOID:363 / uterine cancer [ tcga ]
T1375 S1375 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]