Protein Information

Cytoscape View


UniProt AC / UniProt ID P05981 / HEPS_HUMAN
Protein Name Serine protease hepsin
Gene Name Name: HPN
Synonyms:TMPRSS1;
Organism Homo sapiens (Human)

PRO ID PR:P05981
DAG View
PRO Name serine protease hepsin (human)
Definition A serine protease hepsin that is encoded in the genome of human.
Short Label hHPN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05981 (HPN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N112 N-Glycosylation UniProt 19159218
Y341 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S362 G362 Biomuta DOID:1909 / melanoma [ tcga ]
S364 C364 Biomuta DOID:2394 / ovarian cancer [ icgc ]