Protein Information

Cytoscape View


UniProt AC / UniProt ID P05787 / K2C8_HUMAN
Protein Name Keratin, type II cytoskeletal 8
Gene Name Name: KRT8
Synonyms:CYK8;
Organism Homo sapiens (Human)

PRO ID PR:P05787
DAG View
PRO Name keratin, type II cytoskeletal 8 (human)
Definition A keratin, type II cytoskeletal 8 that is encoded in the genome of human.
Short Label hKRT8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05787 (KRT8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
T6 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
K8 Acetylation PhosphoSitePlus
K8 Methylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
S9 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   UniProt 8660345, 1374067
Y10 Phosphorylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Methylation PhosphoSitePlus
K11 Sumoylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
S13 O-Glycosylation PhosphoSitePlus
S13 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   UniProt 8660345, 23186163
T14 Phosphorylation PhosphoSitePlus
S15 O-Glycosylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   UniProt 24275569
R18 Methylation PhosphoSitePlus
S21 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16083285, 23186163
S22 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 24275569
R23 Methylation PhosphoSitePlus   UniProt 24129315
S24 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 1374067, ...9054461, 18669648, 8660345
Y25 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T26 Phosphorylation PhosphoSitePlus
S27 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
S31 Phosphorylation PhosphoSitePlus   UniProt 23186163
R32 Methylation PhosphoSitePlus   UniProt 24129315
S34 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 8660345, 18669648, 23186163, ...17081983
S35 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S36 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S37 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus 8660345, 18669648, 16083285, ...17081983
S39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R40 Methylation PhosphoSitePlus   UniProt 24129315
S43 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 18669648, 8660345
S44 Phosphorylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus   UniProt 24129315
Y54 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S74 Phosphorylation P36507 (MAP2K2) , O15264 (MAPK13) , Q05655 (PRKCD) , P53778 (MAPK12) , Q16539 (MAPK14) , Q15759 (MAPK11) , P45983 (MAPK8) , Q02750 (MAP2K1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15972820, 23358244, 11781324, ...15939799, 11788583, 20724476
T89 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K101 Methylation PhosphoSitePlus
K101 Sumoylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Methylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
K130 Acetylation PhosphoSitePlus
K130 Sumoylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K178 Methylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus
K185 Methylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
K197 Sumoylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
Y204 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K207 Acetylation PhosphoSitePlus   UniProt 19608861
K207 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus   UniProt 20068231
S240 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T242 Phosphorylation PhosphoSitePlus
S243 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S247 Phosphorylation PhosphoSitePlus
S251 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S253 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 18669648, 24275569
S258 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18669648, 24275569
K264 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 24003221
S274 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S280 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K285 Methylation PhosphoSitePlus
K285 Sumoylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus   UniProt 23186163
K295 Acetylation PhosphoSitePlus   UniProt 19608861
K295 Ubiquitination PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
K304 Sumoylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K325 Acetylation PhosphoSitePlus   UniProt 19608861
K325 Sumoylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
S330 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
K347 Acetylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
K364 Sumoylation PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
K393 Acetylation PhosphoSitePlus
K393 Sumoylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
S400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S404 Phosphorylation PhosphoSitePlus   UniProt 23186163
S410 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T413 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 8660345
Y419 Phosphorylation PhosphoSitePlus
S424 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S425 Phosphorylation PhosphoSitePlus
Y427 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T431 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus 9054461, 18669648
S432 Phosphorylation P27361 (MAPK3) , P06493 (CDK1) , P45983 (MAPK8) phospho.ELM   PhosphoSitePlus   Signor   UniProt 22344252, 21840417, 9054461, ...18669648, 9524113
S436 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y437 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S438 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S441 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S442 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S445 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S449 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S451 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
S453 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
K465 Acetylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
K472 Acetylation PhosphoSitePlus
K472 Sumoylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
S475 O-Glycosylation PhosphoSitePlus
S475 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 20068231
S477 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S478 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K483 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 20068230
S13 Phosphorylation HPRD 19007248
T14 Phosphorylation HPRD 19007248
S21 Phosphorylation HPRD 18669648, 16083285, 19007248, ...20068231
S22 Phosphorylation HPRD 9054461, 18212344, 19007248
S24 Phosphorylation HPRD 18691976, 19664995, 19007248, ...9054461, 18669648, 20166139, 17924679
Y25 Phosphorylation HPRD 18669648, 17081983, 20068231, ...19415658
T26 Phosphorylation HPRD 20166139, 19007248, 17924679
S27 Phosphorylation HPRD 17081983, 18669648, 18212344, ...16964243
S34 Phosphorylation HPRD 18669648, 18212344, 19007248, ...17081983
S35 Phosphorylation HPRD 18669648, 19664995
S36 Phosphorylation HPRD 18669648, 19007248
S37 Phosphorylation HPRD 18691976, 16083285, 18212344, ...18767875, 19007248, 19664995, 18669648, 20166139, 16565220
S39 Phosphorylation HPRD 18669648, 18212344, 19007248
S43 Phosphorylation HPRD 18691976, 16083285, 18212344, ...19007248, 18669648, 20166139
S44 Phosphorylation HPRD 18212344
S74 Phosphorylation P27361 (MAPK3) , Q16539 (MAPK14) , P45983 (MAPK8) , P28482 (MAPK1) HPRD 9211903, 18691976, 11788583, ...19007248, 11781324
S104 Phosphorylation HPRD 18212344
Y204 Phosphorylation HPRD 18083107
Y228 Phosphorylation HPRD 20068231
S240 Phosphorylation HPRD 18669648, 20068231
S243 Phosphorylation HPRD 18669648, 19007248
S251 Phosphorylation HPRD 18669648
S253 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20166139, 18452278
S258 Phosphorylation HPRD 18691976, 19664995, 18452278, ...19651622, 18669648, 19007248, 19415658
Y267 Phosphorylation HPRD 18083107
S274 Phosphorylation HPRD 18691976, 18669648
S315 Phosphorylation HPRD 20166139
S330 Phosphorylation HPRD 18669648, 17081983, 19007248
S400 Phosphorylation HPRD 18669648, 19007248, 20068231
S410 Phosphorylation HPRD 18212344, 19007248
S424 Phosphorylation HPRD 18669648
Y427 Phosphorylation HPRD 18669648
T431 Phosphorylation HPRD 18669648
S432 Phosphorylation P27361 (MAPK3) HPRD 9054461, 18669648, 11788583
S436 Phosphorylation HPRD 18669648
Y437 Phosphorylation HPRD 18669648
S438 Phosphorylation HPRD 18669648, 19007248
S441 Phosphorylation HPRD 18669648, 19007248
S442 Phosphorylation HPRD 18669648, 19007248
S445 Phosphorylation HPRD 18669648
S451 Phosphorylation HPRD 16565220
S456 Phosphorylation HPRD 19007248
S475 Phosphorylation HPRD 17081983, 19664994, 19007248, ...19664995, 18669648, 20166139, 18212344
S477 Phosphorylation HPRD 18669648
S478 Phosphorylation HPRD 18669648, 18212344, 19007248, ...17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T6 A6 Biomuta DOID:363 / uterine cancer [ tcga ]
S9 F9 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S15 F15 Biomuta DOID:1324 / lung cancer [ cosmic ]
R23 C23 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
S31 Y31 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S31 A31 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:3571 / liver cancer [ tcga ] DOID:1324 / lung cancer [ tcga ] DOID:2531 / hematologic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:2394 / ovarian cancer [ tcga ] DOID:5041 / esophageal cancer [ tcga ] DOID:2994 / germ cell cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:4362 / cervical cancer [ tcga ] DOID:1115 / sarcoma [ tcga ] DOID:263 / kidney cancer [ tcga ] DOID:3953 / adrenal gland cancer [ tcga ] DOID:3963 / thyroid carcinoma [ icgc ]
S36 L36 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S36 W36 Biomuta DOID:1612 / breast cancer [ icgc ]
S37 C37 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S104 Y104 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y204 * Biomuta DOID:3571 / liver cancer [ icgc ]
K207 N207 Biomuta DOID:363 / uterine cancer [ tcga ]
S247 P247 Biomuta DOID:3070 / malignant glioma [ tcga ]
S291 T291 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S330 F330 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S354 Y354 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1115 / sarcoma [ icgc, tcga ]
K393 N393 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T413 M413 Biomuta DOID:3070 / malignant glioma [ tcga ]
S425 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S449 A449 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S458 T458 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T468 A468 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K483 M483 Biomuta DOID:1909 / melanoma [ icgc, tcga ]