Protein Information

Cytoscape View


UniProt AC / UniProt ID P05783 / K1C18_HUMAN
Protein Name Keratin, type I cytoskeletal 18
Gene Name Name: KRT18
Synonyms:CYK18;ORFNames:PIG46;
Organism Homo sapiens (Human)

PRO ID PR:P05783
DAG View
PRO Name keratin, type I cytoskeletal 18 (human)
Definition A keratin, type I cytoskeletal 18 that is encoded in the genome of human.
Short Label hKRT18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05783 (KRT18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S2 Acetylation UniProt 7538124
S2 Phosphorylation PhosphoSitePlus
T4 Phosphorylation PhosphoSitePlus
S7 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16083285, 19007248, 19664995, ...18669648, 20166139, 20068231
T8 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19664995, 20068231
S10 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 19007248, ...19664995
T11 Phosphorylation HPRD   PhosphoSitePlus 20068230
Y13 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
R14 Methylation PhosphoSitePlus
S15 O-Glycosylation GlyGen 27059955, 17084817, 31637018, ...24126823, 20729549, 18369606, 26853435, 30059200, 9079710, 7538124, 23576270, 22967762, 28510447, 22121020, 29237092, 20068230
S15 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 19007248, 20068231, ...17924679
S18 O-Glycosylation GlyGen 27059955, 17084817, 31637018, ...24126823, 20729549, 18369606, 26853435, 30059200, 9079710, 7538124, 23576270, 22967762, 28510447, 22121020, 29237092, 20068230
S18 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19664994, 19007248, ...18669648, 17924679
S23 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19007248
Y24 Phosphorylation HPRD   PhosphoSitePlus 18669648
R27 Methylation PhosphoSitePlus
S30 O-Glycosylation GlyGen   PhosphoSitePlus 1371281, 27059955, 17084817, ...31637018, 24126823, 20729549, 18369606, 26853435, 30059200, 9079710, 7538124, 23576270, 22967762, 28510447, 22121020, 29237092, 20068230
S30 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 27059955, 18669648, 20068231
S31 O-Glycosylation GlyGen   PhosphoSitePlus 27059955, 17084817, 31637018, ...24126823, 20729549, 18369606, 26853435, 30059200, 9079710, 7538124, 23576270, 22967762, 28510447, 22121020, 29237092, 20068230
S31 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19007248
S34 O-Glycosylation GlyGen 27059955, 17084817, 31637018, ...24126823, 20729549, 18369606, 26853435, 30059200, 9079710, 7538124, 23576270, 22967762, 28510447, 22121020, 29237092, 20068230
S34 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16083285, 23186163, 19007248, ...18669648, 20068231, 32632966, 15368451, 19415658, 9524113
Y36 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19007248, 20068231
S42 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 18669648, 19007248, ...20068231
S44 Phosphorylation HPRD   PhosphoSitePlus 19007248, 20068231
R45 Methylation PhosphoSitePlus   UniProt 24129315
S47 Phosphorylation HPRD   PhosphoSitePlus 19007248, 20068231
S49 O-Glycosylation GlyGen   PhosphoSitePlus 1371281, 27059955, 17084817, ...31637018, 24126823, 20729549, 18369606, 26853435, 30059200, 9079710, 7538124, 23576270, 22967762, 28510447, 22121020, 29237092, 20068230
S49 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
R50 Methylation PhosphoSitePlus
S51 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
T52 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
S53 Phosphorylation P17252 (PRKCA) , Q9UBS0 (RPS6KB2) , P49137 (MAPKAPK2) , Q02156 (PRKCE) , P51812 (RPS6KA3) , Q9UQM7 (CAMK2A) , Q14012 (CAMK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16424149, 17084817, 20724476, ...1374067, 7523419, 19007248, 18669648, 9298992, 15368451, 20068231, 17924679
R55 Methylation PhosphoSitePlus   UniProt 24129315
S60 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...20166139, 20068231, 17924679
T65 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569, ...17081983
K81 Acetylation PhosphoSitePlus
K81 Sumoylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
R90 Methylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y94 Phosphorylation PhosphoSitePlus
R97 Methylation PhosphoSitePlus
S100 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 19007248, 20068231
S110 Phosphorylation PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K118 Methylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S127 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y129 Phosphorylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus   UniProt 19608861
K131 Methylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
K167 Methylation PhosphoSitePlus
K167 Sumoylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
S177 Phosphorylation HPRD   PhosphoSitePlus   UniProt 24275569, 20068231
K187 Acetylation PhosphoSitePlus
K187 Methylation PhosphoSitePlus
K187 Sumoylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
K207 Sumoylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K247 Sumoylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K269 Sumoylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T302 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 18669648
S305 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163, 19664995, ...24275569
S312 Phosphorylation PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
K317 Sumoylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
S319 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S323 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y331 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K372 Acetylation PhosphoSitePlus
K372 Sumoylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
S398 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 19664995, 18452278, ...18669648, 24275569, 20166139, 19415658, 20068231
S399 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...18452278, 18669648, 24275569, 20166139, 20068231
S401 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664995, 18452278, 18669648, ...24275569, 20166139, 20068231
T404 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 24275569, 19007248
K407 Ubiquitination PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
K417 Acetylation PhosphoSitePlus
K417 Sumoylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
S420 Phosphorylation HPRD   PhosphoSitePlus 19651622, 19007248
T422 Phosphorylation PhosphoSitePlus
N423 N-Glycosylation GlyGen 29741879
T425 Phosphorylation HPRD   PhosphoSitePlus 19651622
K426 Acetylation PhosphoSitePlus   UniProt 19608861
K426 Methylation PhosphoSitePlus
K426 Sumoylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036270 (hKRT18/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R27 W27 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S34 R34 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R45 P45 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R50 C50 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S86 N86 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y168 C168 Biomuta DOID:0070003 / blastoma [ cosmic ]
S242 Y242 Biomuta DOID:3070 / malignant glioma [ tcga ]
K247 N247 Biomuta DOID:363 / uterine cancer [ tcga ]
S305 F305 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K317 E317 Biomuta DOID:1909 / melanoma [ cosmic ]
K417 Q417 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]