iPTMnet Report for P05771 (PRKCB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05771 / KPCB_HUMAN
Protein Name Protein kinase C beta type
Gene Name Name: PRKCB
Synonyms:PKCB,PRKCB1;
Organism Homo sapiens (Human)

PRO ID PR:P05771
DAG View
PRO Name protein kinase C beta type (human)
Definition A protein kinase C beta type that is encoded in the genome of human.
Short Label hPRKCB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05771 (PRKCB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 12665801
S11 Phosphorylation PhosphoSitePlus   UniProt 23186163
T17 Phosphorylation PhosphoSitePlus   UniProt 23186163
K23 Ubiquitination PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
Y123 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus   UniProt 23186163
K216 Ubiquitination PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus   UniProt 23186163
T314 Phosphorylation PhosphoSitePlus   UniProt 23186163
K315 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
T364 Phosphorylation PhosphoSitePlus
Y368 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
T500 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8749392, 17115692, 17227757, ...18006785, 17192257, 9889098
T500 Phosphorylation O15530 (PDPK1) neXtProt   Signor 17115692, 9889098
T500 Phosphorylation P53004 (BLVRA) neXtProt   PhosphoSitePlus   Signor 17227757
T504 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 17192257
Y507 Phosphorylation PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
L641 Phosphorylation IntAct   UniProt 19369195, 23866081, 24275569
T642 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18088087, 17115692, 15314172, ...18981301, 23186163
T642 Phosphorylation P05771 (PRKCB) Signor 17115692
T644 Phosphorylation PhosphoSitePlus
F660 Phosphorylation UniProt 19369195, 24275569
S661 Phosphorylation PRO   PhosphoSitePlus   Signor   UniProt 10828076, 17115692
S661 Phosphorylation P05771 (PRKCB) Signor   UniProt 10828076, 17115692
Y662 Phosphorylation neXtProt 12881490
Y662 Phosphorylation P43405 (SYK) neXtProt 12881490
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 19651622
S16 Phosphorylation HPRD 8327493
S16 Phosphorylation P05771 (PRKCB) HPRD 8327493
T17 Phosphorylation HPRD 8327493
T17 Phosphorylation P05771 (PRKCB) HPRD 8327493
T500 Phosphorylation HPRD 20166139, 7961692
T635 Phosphorylation HPRD 8327493
T635 Phosphorylation P05771 (PRKCB) HPRD 8327493
T642 Phosphorylation HPRD 18088087, 8327493
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 19651622
S16 Phosphorylation HPRD 8327493
S16 Phosphorylation P05771 (PRKCB) HPRD 8327493
T17 Phosphorylation HPRD 8327493
T17 Phosphorylation P05771 (PRKCB) HPRD 8327493
T500 Phosphorylation HPRD   PRO 20166139, 7961692, 8749392
R631 Methylation PhosphoSitePlus
T634 Phosphorylation PhosphoSitePlus
T641 Phosphorylation HPRD   PRO   PhosphoSitePlus 8749392, 19651622, 20166139, ...18510355, 8034726
S654 Phosphorylation HPRD   PhosphoSitePlus 19651622
S660 Phosphorylation HPRD   PRO   PhosphoSitePlus 10828076, 8749392, 20230923, ...19651622, 11006297, 20166139
S660 Phosphorylation P05771 (PRKCB) PhosphoSitePlus 11006297, 10828076
S664 Phosphorylation PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus


P05771 (PRKCB) as PTM Enzyme



Substrate Site Score Source PMID
O15350 (TP73) S388 PhosphoSitePlus 19158275
O15519-2 (CFLAR) S193 PhosphoSitePlus 19343040
O95786 (RIGI) S8 neXtProt 22114345
O95786 (RIGI) T170 neXtProt 22114345
P04004 (VTN) S381 HPRD 9030777
P04049 (RAF1) S497 Signor 8288587
P04049 (RAF1) S619 Signor 8288587
P04083 (ANXA1) S27 Signor 24103589
P04083 (ANXA1) S28 PhosphoSitePlus 19428336
P05107 (ITGB2) S745 PhosphoSitePlus   Signor 11700305
P05107 (ITGB2) T758 PhosphoSitePlus   Signor 11700305
P05771-1 (PRKCB) S16 HPRD 8327493
P05771-2 (PRKCB) T17 HPRD 8327493
P05771-1 (PRKCB) T635 HPRD 8327493
P05771 (PRKCB) T642 Signor 17115692
P05771-2 (PRKCB) S660 PhosphoSitePlus 11006297, 10828076
P05771 (PRKCB) S661 Signor   UniProt 10828076, 17115692
P06127 (CD5) T434 HPRD   Signor 11123317
P06127 (CD5) T436 HPRD   Signor 11123317
P06400 (RB1) S249 neXtProt 11805327
P06400 (RB1) T252 neXtProt 11805327
P06400 (RB1) S780 neXtProt 11805327
P06400 (RB1) S795 neXtProt 11805327
P06400 (RB1) T821 neXtProt 11805327
P06730-1 (EIF4E) S209 HPRD 8662663
P07355-1 (ANXA2) S2 HPRD 20068231, 8898866
P07355-2 (ANXA2) S20 HPRD 20068231, 8898866
P07355 (ANXA2) S26 neXtProt   PhosphoSitePlus 18412141
P10636-8 (MAPT) S258 PhosphoSitePlus 11104762
P10636-8 (MAPT) S293 PhosphoSitePlus 11104762
P10636-8 (MAPT) S324 PhosphoSitePlus 11104762
P10636-8 (MAPT) S352 PhosphoSitePlus 11104762
P11171-4 (EPB41) S312 HPRD   PhosphoSitePlus 15611095
P11388-1 (TOP2A) S29 HPRD   Signor 18691976, 7499337, 12569090, ...19007248, 19691289
P11473 (VDR) S51 RLIMS-P+ 8392065
P14598 (NCF1) S303 neXtProt   PhosphoSitePlus   Signor 12056906
P14598 (NCF1) S304 neXtProt   PhosphoSitePlus   Signor 12056906
P14598 (NCF1) S315 neXtProt   PhosphoSitePlus   Signor 12056906
P14598 (NCF1) S320 neXtProt   PhosphoSitePlus   Signor 12056906
P14598 (NCF1) S328 neXtProt   PhosphoSitePlus   Signor 12056906
P14598 (NCF1) S359 neXtProt   PhosphoSitePlus   Signor 12056906
P14598 (NCF1) S370 neXtProt   PhosphoSitePlus   Signor 12056906
P14598 (NCF1) S379 neXtProt   PhosphoSitePlus   Signor 12056906
P14679 (TYR) S523 neXtProt   PhosphoSitePlus   Signor 10347209
P14679 (TYR) S527 neXtProt   PhosphoSitePlus   Signor 10347209
P15336 (ATF2) S121 PhosphoSitePlus 19176525
P16949 (STMN1) S25 PhosphoSitePlus   Signor 7637391, 9271428, 8314790
P16949 (STMN1) S38 PhosphoSitePlus   Signor 7637391, 9271428, 8314790
P17302 (GJA1) S368 HPRD 10871288
P17677-1 (GAP43) S41 HPRD 8694767, 2140056
P19429 (TNNI3) S42 Signor 15769444
P19429 (TNNI3) S44 Signor 15769444
P19429 (TNNI3) T143 Signor 17010989
P19484 (TFEB) S462 neXtProt 23599343
P19484 (TFEB) S463 neXtProt 23599343
P19484 (TFEB) S467 neXtProt 23599343
P19484 (TFEB) S469 neXtProt 23599343
P20700 (LMNB1) S395 HPRD   PhosphoSitePlus 20068231, 8034666, 8463284
P20700 (LMNB1) S405 HPRD   PhosphoSitePlus   Signor 8463284, 8034666
P21730 (C5AR1) S334 PhosphoSitePlus   Signor 17145764
P26010-1 (ITGB7) T783 HPRD 12682249
P28329-3 (CHAT) T255 HPRD   PhosphoSitePlus 15381704
P28329-3 (CHAT) S346 HPRD   PhosphoSitePlus 15381704
P28329-3 (CHAT) S347 HPRD   PhosphoSitePlus 15381704
P28329 (CHAT) T373 HPRD   Signor 12486117, 15381704
P28329-3 (CHAT) S440 HPRD   PhosphoSitePlus 15381704
P28329 (CHAT) S464 HPRD   Signor 15381704
P28329 (CHAT) S465 HPRD   Signor 15381704
P28329-3 (CHAT) S476 HPRD   PhosphoSitePlus 15381704
P28329 (CHAT) S558 HPRD   Signor 15381704
P28329-1 (CHAT) S594 HPRD   Signor 15381704
P28799 (GRN) S81 PhosphoSitePlus 26005049
P29353 (SHC1) S36 neXtProt 20685851
P29474 (NOS3) T495 Signor 24379783
P29966 (MARCKS) S159 HPRD 18767875, 8557118, 11930178, ...20068231
P29966 (MARCKS) S163 HPRD 18669648, 17287340, 11930178, ...20068231, 8557118
P29966 (MARCKS) S170 HPRD 19413330, 17322306, 18578522, ...17287340, 18212344, 18767875, 20058876, 19664995, 19651622, 18669648, 18707149, 20166139, 20068231
P30086 (PEBP1) S153 HPRD 14654844, 20166139, 12551925, ...20068231
P31749 (AKT1) T308 PhosphoSitePlus 10874027
P31749 (AKT1) S473 neXtProt   PhosphoSitePlus 10874027, 19686698
P34741 (SDC2) S187 HPRD 19901323, 9244383
P34741 (SDC2) S188 HPRD 19901323, 9244383
P35548 (MSX2) T135 neXtProt   PhosphoSitePlus 22633971
P35548 (MSX2) T141 neXtProt   PhosphoSitePlus 22633971
P35568 (IRS1) S323 PhosphoSitePlus 16611834
P35568 (IRS1) S441 PhosphoSitePlus 16611834
P35637 (FUS) S257 PhosphoSitePlus 10913197
P41180-1 (CASR) T888 HPRD   Signor 9694886, 12356761
P41594-2 (GRM5) S840 HPRD 15894802
P43629 (KIR3DL1) S415 PhosphoSitePlus 17911614
P48736 (PIK3CG) S582 neXtProt   PhosphoSitePlus 23824069
P49768 (PSEN1) S346 Signor 14576165
P49840 (GSK3A) S21 HPRD   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
P49841 (GSK3B) S9 PhosphoSitePlus 11884598
P55042 (RRAD) S214 HPRD 9677319
P55042 (RRAD) S257 HPRD 7876254, 9677319
P55042 (RRAD) S290 HPRD 9677319
P55042 (RRAD) S299 HPRD 9677319
P56537-2 (EIF6) T215 HPRD 14654845
P56537-1 (EIF6) T234 HPRD 14654845
P56537 (EIF6) S235 neXtProt   Signor 14654845, 21665150
P61764-1 (STXBP1) S306 HPRD 8631738, 12519779
P61764-1 (STXBP1) S313 HPRD 12950453, 8631738, 12519779
P62491 (RAB11A) S177 neXtProt   PhosphoSitePlus 22188018
P98082-1 (DAB2) S24 HPRD   PhosphoSitePlus 10542228
Q01844 (EWSR1) S266 Signor 9341188
Q03721 (KCNC4) S8 PhosphoSitePlus 9649584
Q03721 (KCNC4) S9 PhosphoSitePlus 9649584
Q03721 (KCNC4) S15 PhosphoSitePlus   Signor 7993631, 9649584
Q03721 (KCNC4) S21 PhosphoSitePlus   Signor 7993631, 9649584
Q05639 (EEF1A2) S53 neXtProt 20923971
Q06124 (PTPN11) S576 HPRD   Signor 11781100
Q06187 (BTK) S180 HPRD   neXtProt   Signor 11598012
Q07869 (PPARA) S179 PhosphoSitePlus 15131257
Q07869 (PPARA) S230 PhosphoSitePlus 15131257
Q12906 (ILF3) S647 neXtProt   PhosphoSitePlus   Signor 20870937
Q13224 (GRIN2B) S1303 HPRD 11306676, 8940188, 12147342
Q13224 (GRIN2B) S1323 HPRD 11306676
Q14847 (LASP1) S146 Signor 12571245
Q16236 (NFE2L2) S40 Signor 12198130
Q16625-1 (OCLN) S340 HPRD 11502742
Q16625 (OCLN) S490 neXtProt   PhosphoSitePlus 22438576
Q5JVS0-1 (HABP4) T354 HPRD   Signor 14699138
Q5JVS0 (HABP4) T375 HPRD   Signor 14699138
Q5T7P8 (SYT6) T283 PhosphoSitePlus   Signor 16111671
Q5T7P8 (SYT6) T417 PhosphoSitePlus   Signor 16111671
Q5T7P8 (SYT6) T418 PhosphoSitePlus   Signor 16111671
Q8NER1 (TRPV1) T705 PhosphoSitePlus 24920628
Q92686 (NRGN) S36 HPRD 8080473
Q96D31 (ORAI1) S27 neXtProt   PhosphoSitePlus   Signor 20534587
Q96D31 (ORAI1) S30 neXtProt   PhosphoSitePlus   Signor 20534587
Q96PH1-4 (NOX5) T494 PhosphoSitePlus 17164239
Q96PH1-4 (NOX5) S498 PhosphoSitePlus 17164239
Q99418-2 (CYTH2) S391 HPRD 10531036
Q99418-1 (CYTH2) S392 HPRD   Signor 10531036
Q9BXL7 (CARD11) S559 neXtProt 16356855
Q9BXL7 (CARD11) S644 neXtProt 16356855
Q9BXL7 (CARD11) S652 neXtProt 16356855
Q9H1D0 (TRPV6) S184 PhosphoSitePlus 19805577
Q9H1D0 (TRPV6) T728 PhosphoSitePlus 19805577
Q9P2D0 (IBTK) S1200 PhosphoSitePlus   Signor 21482705
Q9P2D0 (IBTK) S1203 PhosphoSitePlus   Signor 21482705
Q9UBS0 (RPS6KB2) S473 neXtProt   PhosphoSitePlus   Signor 12529391
Q9UBU3 (GHRL) S41 PhosphoSitePlus 18343535
Q9UQ80-1 (PA2G4) S363 HPRD   Signor 11325528, 20068231
Q9UQ80-1 (PA2G4) T366 HPRD   Signor 11325528
Q9Y4H2 (IRS2) S306 neXtProt 23775122
Q9Y4H2 (IRS2) S679 neXtProt 23775122


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048914 (hPRKCB/InitMet-/Phos:1) pT500 PRO
PR:000048915 (hPRKCB/InitMet-/Phos:2) pT500,pT642,pS661 PRO
PR:000049887 (hPRKCB/Phos:1) pT500 PRO 8749392
PR:000049853 (hPRKCB/iso:Beta-II/InitMet-/Phos:1) pT500 PRO 8749392
PR:000049855 (hPRKCB/iso:Beta-II/InitMet-/Phos:2) pT500,pT641,pS660 PRO 8749392


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T40 A40 Biomuta DOID:1324 / lung cancer [ cosmic ]
T40 I40 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S51 R51 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K76 T76 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y195 H195 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K216 E216 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T314 A314 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc, tcga ]
K315 N315 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K350 N350 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S352 G352 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S352 N352 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K468 R468 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K481 N481 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K489 N489 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
T498 A498 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T498 I498 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T498 S498 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K499 N499 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T504 I504 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T504 N504 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y515 N515 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y515 F515 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K595 N595 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R631 Q631 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S660 F660 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
F660 L660 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S660 Y660 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S661 C661 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S664 F664 Biomuta DOID:1324 / lung cancer [ cosmic ]
K668 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K668 I668 Biomuta DOID:4159 / skin cancer [ cosmic ]
S673 N673 Biomuta DOID:363 / uterine cancer [ cosmic ]