Protein Information

Cytoscape View


UniProt AC / UniProt ID P05556 / ITB1_HUMAN
Protein Name Integrin beta-1 precursor
Gene Name Name: ITGB1
Synonyms:FNRB,MDF2,MSK12;
Organism Homo sapiens (Human)

PRO ID PR:P05556
DAG View
PRO Name integrin beta-1 (human)
Definition An integrin beta-1 that is encoded in the genome of human.
Short Label hITGB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05556 (ITGB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K71 Ubiquitination PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
N212 N-Glycosylation UniProt 19159218
K220 Ubiquitination PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
N269 N-Glycosylation UniProt 22451694
T271 Phosphorylation PhosphoSitePlus
K289 Acetylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
T394 O-Glycosylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
N406 N-Glycosylation UniProt 16335952, 22451694, 19349973
N481 N-Glycosylation UniProt 19159218
K540 Ubiquitination PhosphoSitePlus
T544 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
N669 N-Glycosylation UniProt 19159218
K672 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y783 Phosphorylation P42684 (ABL2) phospho.ELM   PhosphoSitePlus   UniProt 18083107, 23186163, 25694433
K784 Ubiquitination PhosphoSitePlus
S785 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P   UniProt 10896784, 20926684, 24275569, ...19005162, 11559760
T788 Phosphorylation Q02156 (PRKCE) , Q9UQM7 (CAMK2A) phospho.ELM   PhosphoSitePlus   RLIMS-P 19115199, 16405888, 14660602, ...19005162, 14502569, 15949469
T789 Phosphorylation Q9UQM7 (CAMK2A) , Q02156 (PRKCE) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19115199, 19887187, 14660602, ...24275569, 19005162, 14502569, 15949469
K794 Acetylation PhosphoSitePlus   UniProt 19608861
K794 Sumoylation PhosphoSitePlus
K794 Ubiquitination PhosphoSitePlus
Y795 Phosphorylation PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S224 Phosphorylation HPRD 20068231
T226 Phosphorylation HPRD 20068231
S327 Phosphorylation HPRD 20068231
T333 Phosphorylation HPRD 20068231
T777 Phosphorylation HPRD 18578522, 19664994
Y783 Phosphorylation HPRD 18083107, 19901323, 18578522, ...20068231, 18707149
S785 Phosphorylation HPRD 18578522
Site PTM Type PTM Enzyme Score Source PMID
K107 Ubiquitination PhosphoSitePlus
Y780 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K107 Ubiquitination PhosphoSitePlus
S224 Phosphorylation HPRD 20068231
T226 Phosphorylation HPRD 20068231
S327 Phosphorylation HPRD 20068231
T333 Phosphorylation HPRD 20068231
Y783 Phosphorylation HPRD   PhosphoSitePlus 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y147 * Biomuta DOID:3571 / liver cancer [ icgc ]
K163 T163 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K402 R402 Biomuta DOID:1324 / lung cancer [ cosmic ]
N669 I669 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K765 E765 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K768 N768 Biomuta DOID:1324 / lung cancer [ tcga ]
T777 A777 Biomuta DOID:363 / uterine cancer [ tcga ]
T777 M777 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T789 I789 Biomuta DOID:363 / uterine cancer [ tcga ]
K794 N794 Biomuta DOID:1324 / lung cancer [ tcga ]