Protein Information

Cytoscape View


UniProt AC / UniProt ID P05549 / AP2A_HUMAN
Protein Name Transcription factor AP-2-alpha
Gene Name Name: TFAP2A
Synonyms:AP2TF,TFAP2;
Organism Homo sapiens (Human)

PRO ID PR:P05549
DAG View
PRO Name transcription factor AP-2-alpha (human)
Definition A transcription factor AP-2-alpha that is encoded in the genome of human.
Short Label hTFAP2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05549 (TFAP2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Sumoylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S185 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S187 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K197 Ubiquitination PhosphoSitePlus
S219 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus 22561688
S223 Phosphorylation PhosphoSitePlus
S225 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K226 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S239 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10037142, 18669648
S258 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   RLIMS-P 18845787
K268 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S326 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   RLIMS-P 18845787
K335 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
S429 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   Signor 21777522
Site PTM Type PTM Enzyme Score Source PMID
S185 Phosphorylation HPRD 18669648
S187 Phosphorylation HPRD 18669648
S222 Phosphorylation HPRD 20068231
S223 Phosphorylation HPRD 20068231
T224 Phosphorylation HPRD 20068231
S225 Phosphorylation HPRD 18669648, 20068231
S239 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 18669648
S181 Phosphorylation HPRD 18669648
S216 Phosphorylation HPRD 20068231
S217 Phosphorylation HPRD 20068231
T218 Phosphorylation HPRD 20068231
S219 Phosphorylation HPRD 18669648, 20068231
S233 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S181 Phosphorylation HPRD 18669648
S183 Phosphorylation HPRD 18669648
S218 Phosphorylation HPRD 20068231
S219 Phosphorylation HPRD 20068231
T220 Phosphorylation HPRD 20068231
S221 Phosphorylation HPRD 18669648, 20068231
S235 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) S1039 P05549 (TFAP2A) decreased_association eFIP 24797263
Phosphorylation P06241 (FYN) Y420 P05549 (TFAP2A) unknown eFIP 28360834
Phosphorylation P17302 (GJA1) S279 P05549 (TFAP2A) increased_association eFIP 23363606
Phosphorylation P17302 (GJA1) S282 P05549 (TFAP2A) increased_association eFIP 23363606


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S181 F181 Biomuta DOID:1115 / sarcoma [ tcga ]
T224 N224 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S239 L239 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K282 * Biomuta DOID:1909 / melanoma [ tcga ]