iPTMnet Report for P05546 (SERPIND1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05546 / HEP2_HUMAN
Protein Name Heparin cofactor 2 precursor
Gene Name Name: SERPIND1
Synonyms:HCF2;
Organism Homo sapiens (Human)

PRO ID PR:P05546
DAG View
PRO Name heparin cofactor 2 (human)
Definition A heparin cofactor 2 that is encoded in the genome of human.
Short Label hSERPIND1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05546 (SERPIND1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 O-Glycosylation GlyGen 30459171
S37 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 26091039
N49 N-Glycosylation GlyGen   UniProt 16335952, 32125861, 19159218, ...29391424, 19139490, 24279413, 29741879, 29671580
S51 O-Glycosylation GlyGen 30459171
T66 Phosphorylation PhosphoSitePlus
Y79 Phosphorylation PhosphoSitePlus
S100 O-Glycosylation GlyGen 30459171
S102 O-Glycosylation GlyGen 30459171
T104 O-Glycosylation GlyGen 30459171
Y138 Phosphorylation PhosphoSitePlus
N188 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 29391424, ...24279413, 29741879, 12169660, 29671580
T328 O-Glycosylation GlyGen 31492838
N387 N-Glycosylation GlyGen   UniProt 12169660
T453 O-Glycosylation GlyGen 30459171
T454 O-Glycosylation GlyGen 30459171
T457 O-Glycosylation GlyGen 30459171
Site PTM Type PTM Enzyme Score Source PMID
N49 N-Glycosylation PRO 29671580
N188 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S102 C102 Biomuta DOID:3571 / liver cancer [ cosmic ]
T104 R104 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T457 M457 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T457 A457 Biomuta DOID:3571 / liver cancer [ cosmic ]