Protein Information

Cytoscape View


UniProt AC / UniProt ID P05412 / JUN_HUMAN
Protein Name Transcription factor AP-1
Gene Name Name: JUN
Organism Homo sapiens (Human)

PRO ID PR:P05412
DAG View
PRO Name transcription factor AP-1 (human)
Definition A transcription factor AP-1 that is encoded in the genome of human.
Short Label hJUN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05412 (JUN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21177766
T8 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21177766
Y26 Phosphorylation P41240 (CSK) RLIMS-P+ 16740711
S37 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
S58 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
T62 Phosphorylation HPRD   PhosphoSitePlus 19413330
S63 Phosphorylation P45983 (MAPK8) , P06493 (CDK1) , Q15139 (PRKD1) , Q96KB5 (PBK) , Q8TD08 (MAPK15) , Q9H4B4 (PLK3) , P53779 (MAPK10) , Q00526 (CDK3) , P27361 (MAPK3) , P45984 (MAPK9) , Q99986 (VRK1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9348296, 16009721, 21296766, ...19860880, 29078276, 26035356, 7737130, 26289944, 21406692, 18212344, 15844359, 25814555, 20490773, 23752190, 12040039, 26445036, 8426747, 16819515, 10509564, 27648299, 23665993, 14579416, 9365242, 11401472, 16934508, 16698017, 15449052, 14657232, 23645983, 15226308, 30531837, 20082306, 16733206, 18419764, 18707149, 28470144, 25121353, 15302935, 21296815, 19664995, 28505077, 12881422, 9687508, 21212517, 24291398, 14739463, 9425017, 10556784, 9988737, 11432833, 31243344, 10974006, 14617628, 11352915, 16834785, 24838122, 11737865, 17671211, 10393085, 25402510, 22860098, 27556506, 11046144, 1630458, 26018080, 9742208, 20058876, 7898927, 22266871, 15389828, 10754497, 29029460, 10788439, 19806201, 10617104, 28057023, 9162025, 11278277, 28539628, 25422452, 28811522, 7935387, 11948398, 19118012, 15138488, 15240010, 27486656, 26745678, 31147584, 9407138, 19818398, 1328860, 17455299, 24038215, 9784400, 23186163, 12947046, 11076965, 18452278, 10667594, 20395206, 12900420, 23942796, 19690332, 11896587, 22561846, 24118792, 26755651, 11961130, 12169099, 9682022, 29285221, 24742962, 9464996, 7877994, 15845392, 9878062, 15860507, 24631457, 18572021, 7937838, 16214953, 22360706, 8137421, 30922965, 12221076, 18669648, 14508071, 21177766, 23792175, 17689131, 18844221, 10064599, 10581177, 20482821, 22406864, 16964287, 24797581, 30887599, 18252863, 15378002, 24606718, 8355696, 12441106, 8036019, 9820149, 27869123, 25823818, 28542209, 15135887, 16481106, 26098773, 8016110, 19413330, 12646240, 17908424, 24512202, 8224842, 8654373, 17804415, 9293774, 24618420, 25121739, 18793328, 1324919, 19604147, 11739718, 22067274, 21364631, 25281487, 25483191, 12853483, 20068231, 16740738, 18650425, 17670986
K70 Ubiquitination PhosphoSitePlus
S73 Phosphorylation Q8TD08 (MAPK15) , P53779 (MAPK10) , Q99986 (VRK1) , P27361 (MAPK3) , P45983 (MAPK8) , Q96KB5 (PBK) , P06493 (CDK1) , Q9H4B4 (PLK3) , P45984 (MAPK9) , Q00526 (CDK3) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21296766, 16009721, 19860880, ...29078276, 26035356, 7737130, 26289944, 15844359, 25814555, 12040039, 26445036, 8426747, 17689131, 12021409, 27648299, 30195772, 1328860, 9365242, 11401472, 21559334, 19664995, 16733206, 9488446, 25121353, 15302935, 21296815, 28505077, 24291398, 14739463, 14690535, 9425017, 27869123, 27590675, 9988737, 11432833, 31243344, 14617628, 23562655, 11352915, 1630458, 24838122, 12881422, 10393085, 22860098, 11046144, 21808000, 16834785, 9742208, 7898927, 22266871, 7935387, 10788439, 19806201, 24068923, 10617104, 28057023, 9162025, 11278277, 28539628, 25422452, 12740383, 7813438, 15240010, 26745678, 31147584, 12531896, 9407138, 29888211, 19818398, 1324919, 17455299, 9784400, 29029460, 30887599, 11076965, 9174618, 10581177, 28184937, 20395206, 22327296, 24118792, 26755651, 25714020, 11961130, 12169099, 25402510, 9464996, 7877994, 11971971, 9878062, 15860507, 18572021, 7937838, 16214953, 11180173, 8137421, 18669648, 21177766, 16819515, 10064599, 10667594, 27089238, 18707149, 22406864, 24797581, 18252863, 15378002, 25797258, 8355696, 28169350, 9651196, 18805449, 8875991, 12441106, 8036019, 9687508, 21860415, 28542209, 15135887, 17325487, 14657232, 8016110, 19937805, 17961201, 24512202, 8224842, 17804415, 9293774, 18793328, 27708396, 21364631, 10523630, 17908424, 25260534, 25281487, 19118012, 12853483, 16740738, 18650425, 24938188
T89 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21177766
T91 Phosphorylation P45983 (MAPK8) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17920329, 15302935, 22266871, ...12853483, 14739463, 19806201
T93 Phosphorylation P45983 (MAPK8) , Q13177 (PAK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17920329, 15302935, 22266871, ...12853483, 21177766, 14739463, 19806201
T95 Phosphorylation PhosphoSitePlus   RLIMS-P 17920329
T131 Phosphorylation RLIMS-P 11823425
Y170 Phosphorylation P00519 (ABL1) , P41240 (CSK) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 15302935, 10637231, 14757045, ...16740711, 19818398
K226 Sumoylation PhosphoSitePlus
T231 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor 17215518, 11075956, 1516134
T239 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 1846781, 16023596, ...1956339, 18669648, 19806201, 21647439
S243 Phosphorylation P06493 (CDK1) , P49841 (GSK3B) , P68400 (CSNK2A1) , Q92630 (DYRK2) , P49840 (GSK3A) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22307329, 1846781, 23186163, ...1421569, 20831597, 19413330, 16023596, 17215518, 26243309, 17952113, 18669648, 21278055, 1516134, 1328860, 19806201, 1651323, 19690332
S249 Phosphorylation P68400 (CSNK2A1) , P78527 (PRKDC) , P49840 (GSK3A) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 8464713, 1846781, ...17215518, 1516134
K254 Sumoylation PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
C269 S-Nitrosylation dbSNO 23796488, 9108029
K271 Acetylation PhosphoSitePlus   UniProt 11689449
K273 Acetylation PhosphoSitePlus
T286 Phosphorylation Q13177 (PAK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21177766
K309 Ubiquitination PhosphoSitePlus
C320 S-Nitrosylation dbSNO 23796488, 9108029
Site PTM Type PTM Enzyme Score Source PMID
K268 Acetylation PR:000007102 (EP300) PRO 18793328
K271 Acetylation PR:000007102 (EP300) PRO 18793328
K273 Acetylation PR:000007102 (EP300) PRO 18793328


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048089 (hJUN/Phos:2) pS63,pS73 PRO
PR:000028616 (hJUN/iso:1/Ac:1) acK268,acK271,acK273 PR:000007102 (EP300) PRO 18793328


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60829 (PAGE4) T51 P05412 (JUN) unknown eFIP 24559171
Phosphorylation P03372 (ESR1) S118 P05412 (JUN) unknown eFIP 22399296
Phosphorylation P05412 (JUN) S73 P01100 (FOS) increased_association eFIP 19860880
Phosphorylation P05412 (JUN) S73 P05412 (JUN) unknown eFIP 28184937


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 I37 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S37 R37 Biomuta DOID:1612 / breast cancer [ cosmic ]
K50 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
S73 L73 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T93 N93 Biomuta DOID:3571 / liver cancer [ icgc ]
T239 K239 Biomuta DOID:3571 / liver cancer [ icgc ]