iPTMnet Report for P05305 (EDN1)
Protein Information
| UniProt AC / UniProt ID | P05305 / EDN1_HUMAN |
| Protein Name | Endothelin-1 precursor |
| Gene Name | Name: EDN1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P05305 |
| PRO Name | endothelin-1 (human) |
| Definition | An endothelin-1 that is encoded in the genome of human. |
| Short Label | hEDN1 |
| Category | organism-gene |
DAG ViewP05305 (EDN1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| C67 | Methylation | score1 | IEDB | 31844290 | ||
| T100 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| K118 | Methylation | score1 | PhosphoSitePlus | |||
| K127 | Methylation | score1 | PhosphoSitePlus | |||
| K143 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K144 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S169 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S170 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T177 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K118 | N118 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K127 | Q127 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
