iPTMnet Report for P05231 (IL6)
Protein Information
| UniProt AC / UniProt ID | P05231 / IL6_HUMAN |
| Protein Name | Interleukin-6 precursor |
| Gene Name | Name: IL6 Synonyms:IFNB2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P05231 |
| PRO Name | interleukin-6 (human) |
| Definition | An interleukin-6 that is encoded in the genome of human. |
| Short Label | hIL6 |
| Category | organism-gene |
DAG ViewP05231 (IL6) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N73 | N-Glycosylation | score4 | GlyGen UniProt | 1883960, 14970177 | ||
| S81 | Phosphorylation | score4 | HPRD UniProt | 26091039, 1610348 | ||
| N89 | N-Glycosylation | score2 | GlyGen | 19690161 | ||
| K94 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S135 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S136 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T165 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P40763 (STAT3) | Y705 | P05231 (IL6) | unknown | eFIP | 22280969 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K94 | N94 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
