iPTMnet Report for P05198 (EIF2S1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05198 / IF2A_HUMAN
Protein Name Eukaryotic translation initiation factor 2 subunit 1
Gene Name Name: EIF2S1
Synonyms:EIF2A;
Organism Homo sapiens (Human)

PRO ID PR:P05198
DAG View
PRO Name eukaryotic translation initiation factor 2 subunit 1 (human)
Definition A eukaryotic translation initiation factor 2 subunit 1 that is encoded in the genome of human.
Short Label hEIF2S1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05198 (EIF2S1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S49 Phosphorylation Q9NZJ5 (EIF2AK3) , Q9BQI3 (EIF2AK1) , P19525 (EIF2AK2) , Q75MR0 (HRI) HPRD   phospho.ELM   PhosphoSitePlus   Signor 16289913, 3352609, 10563826, ...2116318, 16288713
S52 Phosphorylation Q05655 (PRKCD) , B4DS64 (PRKRIR) , P51812 (RPS6KA3) , P19525 (EIF2AK2) , P28482 (MAPK1) , Q75MR0 (HRI) , Q9BQI3 (EIF2AK1) , Q9NZJ5 (EIF2AK3) , Q16539 (MAPK14) , Q9P2K8 (EIF2AK4) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 18063576, 11337501, 8099443, ...17998206, 9819435, 10542257, 17404396, 20385091, 11907036, 15314157, 10504407, 16179259, 16179258, 30070006, 7641700, 19690332, 17553788, 24275569, 7622470, 15355306, 11041858, 25660019, 15684420, 16288713, 11432733, 3352609, 32513922, 15060162, 9930704, 1677563
S58 Phosphorylation HPRD   PhosphoSitePlus 20068231
K61 Ubiquitination PhosphoSitePlus
C70 Methylation IEDB 31844290
K80 Ubiquitination PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
R133 Methylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus   UniProt 19608861
K141 Ubiquitination PhosphoSitePlus
K143 Acetylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K154 Methylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus   UniProt 23186163
T185 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
N217 N-Glycosylation GlyGen 24190977
S219 O-Glycosylation GlyGen 33214551, 25937070, 35138101, ...32574038, 34725712, 34019948, 32119511, 28657654
S219 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
T239 O-Glycosylation GlyGen 33214551, 25937070, 35138101, ...32574038, 34725712, 34019948, 32119511, 28657654
T240 O-Glycosylation GlyGen 33214551, 25937070, 35138101, ...32574038, 34725712, 34019948, 32119511, 28657654
T241 O-Glycosylation GlyGen 33214551, 25937070, 35138101, ...32574038, 34725712, 34019948, 32119511, 28657654
T245 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
R266 Methylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus   UniProt 23186163
T281 Phosphorylation PhosphoSitePlus   UniProt 23186163
T284 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047266 (hEIF2S1/Phos:1) pS52 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C70 Y70 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K123 N123 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S158 L158 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T185 I185 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y200 F200 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T239 M239 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T239 R239 Biomuta DOID:1319 / brain cancer [ cosmic ]
R266 M266 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T279 I279 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K312 N312 Biomuta DOID:3571 / liver cancer [ cosmic ]