iPTMnet Report for P05187 (ALPP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05187 / PPB1_HUMAN
Protein Name Alkaline phosphatase, placental type precursor
Gene Name Name: ALPP
Synonyms:PLAP;
Organism Homo sapiens (Human)

PRO ID PR:P05187
DAG View
PRO Name alkaline phosphatase, placental type (human)
Definition An alkaline phosphatase, placental type that is encoded in the genome of human.
Short Label hALPP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05187 (ALPP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K46 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S114 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T117 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T119 Phosphorylation HPRD 20068231
K126 Ubiquitination PhosphoSitePlus
N144 N-Glycosylation GlyGen   UniProt 15946677, 16815919, 20693656
K163 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
N271 N-Glycosylation GlyGen   UniProt 15946677, 16815919, 20693656
T273 Phosphorylation HPRD   PhosphoSitePlus 20058876
S283 Phosphorylation HPRD 20068231
T314 Phosphorylation HPRD   PhosphoSitePlus 20068231
T367 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
Y410 Phosphorylation HPRD   PhosphoSitePlus 20068231
T411 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y421 Phosphorylation HPRD   PhosphoSitePlus 20068231
K424 Ubiquitination PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T53 I53 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T119 M119 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S177 L177 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S177 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y182 D182 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y191 H191 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N271 K271 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T411 M411 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y415 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S438 N438 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]