iPTMnet Report for P05181 (CYP2E1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05181 / CP2E1_HUMAN
Protein Name Cytochrome P450 2E1
Gene Name Name: CYP2E1
Synonyms:CYP2E;
Organism Homo sapiens (Human)

PRO ID PR:P05181
DAG View
PRO Name cytochrome P450 2E1 (human)
Definition A cytochrome P450 2E1 that is encoded in the genome of human.
Short Label hCYP2E1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05181 (CYP2E1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
R379 Methylation PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T69 R69 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T69 M69 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y83 C83 Biomuta DOID:1324 / lung cancer [ cosmic ]
K94 T94 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S129 F129 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]