iPTMnet Report for P05166 (PCCB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05166 / PCCB_HUMAN
Protein Name Propionyl-CoA carboxylase beta chain, mitochondrial precursor
Gene Name Name: PCCB
Organism Homo sapiens (Human)

PRO ID PR:P05166
DAG View
PRO Name propionyl-CoA carboxylase beta chain, mitochondrial (human)
Definition A propionyl-CoA carboxylase beta chain, mitochondrial that is encoded in the genome of human.
Short Label hPCCB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05166 (PCCB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T45 O-Glycosylation GlyGen 30379171
T45 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus   UniProt 24275569
K143 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K526 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K232 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K248 N248 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
S322 F322 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K433 E433 Biomuta DOID:4159 / skin cancer [ cosmic ]