iPTMnet Report for P05164 (MPO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05164 / PERM_HUMAN
Protein Name Myeloperoxidase precursor
Gene Name Name: MPO
Organism Homo sapiens (Human)

PRO ID PR:P05164
DAG View
PRO Name myeloperoxidase (human)
Definition A myeloperoxidase that is encoded in the genome of human.
Short Label hMPO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05164 (MPO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K103 Acetylation PhosphoSitePlus
N139 N-Glycosylation GlyGen   UniProt 16335952
S191 Phosphorylation PhosphoSitePlus
S322 O-Glycosylation GlyGen 28657654
N323 N-Glycosylation GlyGen   UniProt 30237853, 29391424, 20332087, ...16740002, 29741879, 29671580
N355 N-Glycosylation GlyGen   UniProt 19159218, 20332087, 29391424, ...32125861, 29741879
S357 Phosphorylation PhosphoSitePlus
N391 N-Glycosylation GlyGen   UniProt 20332087, 30237853, 19159218, ...29741879
T428 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S481 O-Glycosylation GlyGen 30237853
N483 N-Glycosylation GlyGen 16335952, 10766826, 29391424, ...20332087, 16740002, 29741879, 29671580, 30237853
Y500 Phosphorylation PhosphoSitePlus
Y516 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
K625 Sumoylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
Y723 Phosphorylation PhosphoSitePlus
N729 N-Glycosylation GlyGen   UniProt 20332087, 29391424
Site PTM Type PTM Enzyme Score Source PMID
N323 N-Glycosylation PRO 29671580
N483 N-Glycosylation PRO 29671580, 10766826


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K103 R103 Biomuta DOID:4159 / skin cancer [ cosmic ]
N323 K323 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S357 F357 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T428 R428 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S481 C481 Biomuta DOID:1324 / lung cancer [ cosmic ]
S481 F481 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
N729 S729 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]