Protein Information

Cytoscape View


UniProt AC / UniProt ID P05132 / KAPCA_MOUSE
Protein Name cAMP-dependent protein kinase catalytic subunit alpha
Gene Name Name: Prkaca
Synonyms:Pkaca;
Organism Mus musculus (Mouse)

PRO ID PR:P05132
DAG View
PRO Name cAMP-dependent protein kinase catalytic subunit alpha (mouse)
Definition A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of mouse.
Short Label mPRKACA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05132 (Prkaca) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation IntAct   UniProt 23458248, 11141074
G10 Phosphorylation IntAct 23458248
S11 Phosphorylation P05132 (Prkaca) PhosphoSitePlus   UniProt 8395513, 11141074
S35 Phosphorylation phospho.ELM   PhosphoSitePlus 17203969
K48 Ubiquitination PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
F139 Phosphorylation IntAct 23458248
S140 Phosphorylation PhosphoSitePlus   UniProt 8395513, 22323819
T184 Phosphorylation PhosphoSitePlus
T196 Phosphorylation phospho.ELM   PhosphoSitePlus 15345747
W197 Phosphorylation IntAct 23458248
T198 Phosphorylation P05132 (Prkaca) , Q9Z2A0 (Pdpk1) phospho.ELM   PhosphoSitePlus   UniProt 8395513, 9488457, 12372837, ...19965870, 22323819, 9707564
C200 S-Nitrosylation dbSNO 22865876
T202 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus   UniProt 21866565
V338 Phosphorylation IntAct 23458248
S339 Phosphorylation P05132 (Prkaca) phospho.ELM   PhosphoSitePlus   UniProt 8395513, 15618230, 19965870, ...17242405
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PRO 9261084
T198 Phosphorylation PRO 14757059, 14705934, 9261084
S339 Phosphorylation PRO 14757059, 14705934, 9261084


P05132 (Prkaca) as PTM Enzyme



Substrate Site Score Source PMID
E9Q401 (Ryr2) S2807 PhosphoSitePlus 16407108
O08553 (Dpysl2) T555 PhosphoSitePlus 24227739
O08759 (Ube3a) T503 Signor 26255772
O08852 (Pkd1) S4159 PhosphoSitePlus 10364454
O54724 (Cavin1) S169 PhosphoSitePlus 21282370
O54724 (Cavin1) S171 PhosphoSitePlus 21282370
O54724 (Cavin1) T304 PhosphoSitePlus 21282370
O54724 (Cavin1) S368 PhosphoSitePlus 21282370
O54851 (Gjd2) S110 PhosphoSitePlus 16956882
O54851 (Gjd2) S293 PhosphoSitePlus 16956882
O54851 (Gjd2) S306 PhosphoSitePlus 16956882
O54851 (Gjd2) S315 PhosphoSitePlus 16956882
O70468 (Mybpc3) S47 PhosphoSitePlus 23619294
O70468 (Mybpc3) T65 PhosphoSitePlus 23619294
O70468 (Mybpc3) S105 PhosphoSitePlus 23619294
O70468 (Mybpc3) S282 PhosphoSitePlus 23619294
O70468 (Mybpc3) T290 PhosphoSitePlus 23619294
O70468 (Mybpc3) S307 PhosphoSitePlus 23619294
O88445 (Aurkc) T171 PhosphoSitePlus 11879579
O88602 (Cacng2) T321 PhosphoSitePlus 11805122
O88809 (Dcx) S47 PhosphoSitePlus 22367209, 14741102
P01101 (Fos) S362 PhosphoSitePlus 21565615
P05132 (Prkaca) S11 UniProt 11141074
P05132 (Prkaca) T198 PhosphoSitePlus 19965870, 9488457, 12372837
P05132 (Prkaca) S339 PhosphoSitePlus 17242405, 15618230, 19965870
P08553 (Nefm) S23 PhosphoSitePlus 9930720
P11416 (Rara) S369 PhosphoSitePlus 7476969
P14602 (Hspb1) S15 PhosphoSitePlus 1860870
P14602 (Hspb1) S86 PhosphoSitePlus 1860870
P20152 (Vim) S7 PhosphoSitePlus 2500966
P20152 (Vim) S25 PhosphoSitePlus 2500966
P20152 (Vim) S39 PhosphoSitePlus 2500966
P20152 (Vim) S47 PhosphoSitePlus 2500966
P20152 (Vim) S51 PhosphoSitePlus 2500966
P20152 (Vim) S66 PhosphoSitePlus 2500966
P23818 (Gria1) S849 PhosphoSitePlus 17360685
P23818 (Gria1) S863 PhosphoSitePlus 25381005
P26645 (Marcks) S152 PhosphoSitePlus 20211725
P26645 (Marcks) S156 PhosphoSitePlus 20211725
P26645 (Marcks) S160 PhosphoSitePlus 20211725
P26645 (Marcks) S163 PhosphoSitePlus 20211725
P27671 (Rasgrf1) S745 PhosphoSitePlus 11018028
P27671 (Rasgrf1) S822 PhosphoSitePlus 11018028
P27699 (Crem) S133 PhosphoSitePlus 8404858, 8114763
P30051 (Tead1) S102 PhosphoSitePlus 10931933
P30306 (Cdc25b) S149 PhosphoSitePlus 21212267, 22348958
P30306 (Cdc25b) S321 PhosphoSitePlus 21212267, 22348958
P41233 (Abca1) S1042 Signor 12196520
P41233 (Abca1) S2054 Signor 12196520
P48787 (Tnni3) S23 PhosphoSitePlus 17615373, 12923217, 15507454
P48787 (Tnni3) S24 PhosphoSitePlus 17615373, 12923217, 15507454
P51180 (Mip) S235 PhosphoSitePlus 22095752
P54310 (Lipe) S557 PhosphoSitePlus   Signor 11581251, 26724218
P54310 (Lipe) S650 Signor 11581251
P54310 (Lipe) S651 PhosphoSitePlus   Signor 24273196, 11581251, 26724218
P54830 (Ptpn5) S221 PhosphoSitePlus 24466306
P60879 (Snap25) T138 PhosphoSitePlus 14766180
P61014 (Pln) S16 PhosphoSitePlus   Signor 10988285
P61014 (Pln) T17 PhosphoSitePlus 10988285
P70181 (Pip5k1b) S214 PhosphoSitePlus 11087761
P70218 (Map4k1) S171 PhosphoSitePlus 17895239
P70441 (Slc9a3r1) S77 PhosphoSitePlus 17975671
Q04207 (Rela) S276 PhosphoSitePlus 9150141
Q07279 (Nfe2) S170 PhosphoSitePlus 9558374
Q0PCR6 (Cacna1c) S1700 PhosphoSitePlus 24835999
Q0PCR6 (Cacna1c) S1927 PhosphoSitePlus 24835999
Q3USB7 (Plcl1) T94 PhosphoSitePlus 15306641
Q3USB7 (Plcl1) S96 PhosphoSitePlus 15306641
Q60829 (Ppp1r1b) T34 PhosphoSitePlus 10604473, 12538871
Q61337 (Bad) S112 PhosphoSitePlus 10230394, 10949026, 16103085, ...9346240, 8929531, 12189144
Q61337 (Bad) S136 PhosphoSitePlus 12189144, 10949026
Q61337 (Bad) S155 PhosphoSitePlus 10949026, 10837486
Q61743 (Kcnj11) T224 PhosphoSitePlus 10698936
Q61792 (Lasp1) T156 PhosphoSitePlus 15465019
Q62261 (Sptbn1) T346 PhosphoSitePlus 9798950
Q66JT0 (Wee2) S15 PhosphoSitePlus 23616086
Q6VV64 (Kcnk18) S264 PhosphoSitePlus 20215114
Q7TNL5 (Ppp2r5d) S53 PhosphoSitePlus 17301223
Q7TNL5 (Ppp2r5d) S68 PhosphoSitePlus 17301223
Q7TNL5 (Ppp2r5d) S566 PhosphoSitePlus 17301223
Q812A2 (Srgap3) S858 PhosphoSitePlus 26499801
Q8CGN5 (Plin1) S81 Signor 11751901
Q8CGN5 (Plin1) S276 Signor 11751901
Q8CGN5 (Plin1) S492 PhosphoSitePlus 19116774
Q8CGN5 (Plin1) S517 PhosphoSitePlus 19116774
Q99N57 (Raf1) S233 PhosphoSitePlus 11997508
Q9CRB9 (Chchd3) T11 PhosphoSitePlus 17242405
Q9DCB4 (Arpp21) S57 PhosphoSitePlus 10854908
Q9EPR4 (Slc23a2) S403 PhosphoSitePlus 17585336
Q9EPR4 (Slc23a2) S640 PhosphoSitePlus 17585336
Q9ERT9 (Ppp1r1a) T35 PhosphoSitePlus 11278334
Q9JM73 (Srf) T155 Signor 12809504
Q9QUI0 (Rhoa) S188 Signor 12654918
Q9QXZ9 (Opn4) S182 PhosphoSitePlus 23049792
Q9QXZ9 (Opn4) T186 PhosphoSitePlus 23049792
Q9QXZ9 (Opn4) S287 PhosphoSitePlus 23049792
Q9WTK7 (Stk11) S431 PhosphoSitePlus 10642527, 11297520
Q9Z0V2 (Kcnd2) T38 PhosphoSitePlus 10681507
Q9Z0V2 (Kcnd2) S552 PhosphoSitePlus 10681507
Q9Z266 (Snapin) S50 PhosphoSitePlus 11283605


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025898 (mPRKACA/iso:1/InitMet-/Phos:1) pS11,pT198,pS339 PRO 9261084
PR:000025900 (mPRKACA/iso:1/InitMet-/Phos:2) pT198,pS339 PRO 14705934, 14757059