Protein Information

Cytoscape View


UniProt AC / UniProt ID P05129 / KPCG_HUMAN
Protein Name Protein kinase C gamma type
Gene Name Name: PRKCG
Synonyms:PKCG;
Organism Homo sapiens (Human)

PRO ID PR:P05129
DAG View
PRO Name protein kinase C gamma type (human)
Definition A protein kinase C gamma type that is encoded in the genome of human.
Short Label hPRKCG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05129 (PRKCG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S109 Phosphorylation RLIMS-P 20214626
S145 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K359 Acetylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K503 Acetylation PhosphoSitePlus
T510 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T511 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T512 Phosphorylation phospho.ELM 18669648
T514 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15964845
T518 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y521 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
T655 Phosphorylation phospho.ELM   PhosphoSitePlus 15964845
T674 Phosphorylation phospho.ELM   PhosphoSitePlus 15964845
Site PTM Type PTM Enzyme Score Source PMID
T510 Phosphorylation HPRD 18669648
T511 Phosphorylation HPRD 18669648
T512 Phosphorylation HPRD 18669648
T514 Phosphorylation HPRD 18669648
T518 Phosphorylation HPRD 18669648
T655 Phosphorylation HPRD 18691976


P05129 (PRKCG) as PTM Enzyme



Substrate Site Score Source PMID
O94768 (STK17B) S351 neXtProt 18084041
P04004 (VTN) S381 HPRD 9030777
P04049 (RAF1) S497 Signor 8288587
P04049 (RAF1) S619 Signor 8288587
P04083 (ANXA1) S27 Signor 24103589
P06127 (CD5) T434 HPRD   PhosphoSitePlus   Signor 11123317
P06127 (CD5) T436 HPRD   PhosphoSitePlus   Signor 11123317
P06730-1 (EIF4E) S209 HPRD 8662663
P07900 (HSP90AA1) T115 PhosphoSitePlus   Signor 24117238
P07900 (HSP90AA1) T425 PhosphoSitePlus   Signor 24117238
P07900 (HSP90AA1) T603 PhosphoSitePlus   Signor 24117238
P08138 (NGFR) S277 PhosphoSitePlus 19710323
P10636-8 (MAPT) S258 PhosphoSitePlus 11104762
P10636-8 (MAPT) S293 PhosphoSitePlus 11104762
P10636-8 (MAPT) S324 PhosphoSitePlus 11104762
P10636-8 (MAPT) S352 PhosphoSitePlus 11104762
P11388-1 (TOP2A) S29 HPRD   Signor 18691976, 7499337, 12569090, ...19007248, 19691289
P17302 (GJA1) S368 HPRD   neXtProt 15459208, 12601045, 15642736, ...10871288
P19429 (TNNI3) S42 Signor 15769444
P19429 (TNNI3) S44 Signor 15769444
P21730 (C5AR1) S334 PhosphoSitePlus 17145764
P25098 (GRK2) S29 HPRD   PhosphoSitePlus   Signor 11042191
P28329-3 (CHAT) T255 PhosphoSitePlus 15381704
P28329-3 (CHAT) S346 PhosphoSitePlus 15381704
P28329-3 (CHAT) S347 PhosphoSitePlus 15381704
P28329 (CHAT) T373 HPRD   Signor 15381704
P28329-3 (CHAT) S440 PhosphoSitePlus 15381704
P28329 (CHAT) S464 HPRD   Signor 15381704
P28329 (CHAT) S465 HPRD   Signor 15381704
P28329-3 (CHAT) S476 PhosphoSitePlus 15381704
P28329 (CHAT) S558 HPRD   Signor 15381704
P28329 (CHAT) S594 HPRD   Signor 15381704
P29474 (NOS3) T495 Signor 24379783
P30086 (PEBP1) S153 HPRD 14654844, 20166139, 12551925, ...20068231
P34741 (SDC2) S187 HPRD 19901323, 9244383
P34741 (SDC2) S188 HPRD 19901323, 9244383
P35568 (IRS1) S1101 HPRD 15364919
P41180 (CASR) T888 HPRD 9694886
P41594-2 (GRM5) S840 HPRD 15894802
P43629 (KIR3DL1) S415 PhosphoSitePlus   Signor 17911614
P48058 (GRIA4) S862 neXtProt   Signor 12471040, 12536214
P49619 (DGKG) S779 neXtProt 16905533
P49619 (DGKG) S782 neXtProt 16905533
P49768 (PSEN1) S346 Signor 14576165
P49840 (GSK3A) S21 HPRD   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11035810
P49841 (GSK3B) S9 PhosphoSitePlus 11884598
P50281 (MMP14) T567 PhosphoSitePlus 19458085
P61764-2 (STXBP1) S306 HPRD 12519779, 8631738
P61764-1 (STXBP1) S313 HPRD 12950453, 8631738, 12519779
P98082 (DAB2) S24 HPRD   PhosphoSitePlus 10542228
Q03721 (KCNC4) S8 PhosphoSitePlus 9649584
Q03721 (KCNC4) S9 PhosphoSitePlus 9649584
Q03721 (KCNC4) S15 PhosphoSitePlus 9649584
Q03721 (KCNC4) S21 PhosphoSitePlus 9649584
Q05586 (GRIN1) S890 neXtProt 15936117
Q13224 (GRIN2B) S1303 HPRD 11306676, 8940188, 12147342
Q13224 (GRIN2B) S1323 HPRD 11306676
Q14155 (ARHGEF7) S518 PhosphoSitePlus   Signor 25009260
Q14155 (ARHGEF7) S761 PhosphoSitePlus   Signor 25009260
Q16625-1 (OCLN) S340 HPRD 11502742
Q5JVS0-1 (HABP4) T354 HPRD   Signor 14699138
Q5JVS0 (HABP4) T375 HPRD   Signor 14699138
Q7Z2E3 (APTX) T125 PhosphoSitePlus   Signor 19561170
Q92686 (NRGN) S36 HPRD 8080473
Q99418-2 (CYTH2) S391 HPRD 10531036
Q99418-1 (CYTH2) S392 HPRD   Signor 10531036
Q9UBS0 (RPS6KB2) S473 PhosphoSitePlus   Signor 12529391
Q9UQ80-1 (PA2G4) S363 HPRD   Signor 11325528, 20068231
Q9UQ80-1 (PA2G4) T366 HPRD   Signor 11325528


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S109 R109 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S148 F148 Biomuta DOID:1324 / lung cancer [ tcga ]
Y195 S195 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K197 R197 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K197 Q197 Biomuta DOID:1324 / lung cancer [ tcga ]
S264 L264 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S361 R361 Biomuta DOID:1909 / melanoma [ cosmic ]
T510 M510 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:11934 / head and neck cancer [ tcga ]
Y521 N521 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y521 C521 Biomuta DOID:11934 / head and neck cancer [ tcga ]