Protein Information

Cytoscape View


UniProt AC / UniProt ID P05107 / ITB2_HUMAN
Protein Name Integrin beta-2 precursor
Gene Name Name: ITGB2
Synonyms:CD18,MFI7;
Organism Homo sapiens (Human)

PRO ID PR:P05107
DAG View
PRO Name integrin beta-2 (human)
Definition An integrin beta-2 that is encoded in the genome of human.
Short Label hITGB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05107 (ITGB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
N50 N-Glycosylation UniProt 19159218, 19349973
K96 Ubiquitination PhosphoSitePlus
N116 N-Glycosylation UniProt 20033057, 19349973
K148 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
N212 N-Glycosylation UniProt 16335952, 19159218, 19349973
K294 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
Y735 Phosphorylation P06239 (LCK) PhosphoSitePlus 22990843
K740 Acetylation PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
S745 Phosphorylation P24723 (PRKCH) , P05771-2 (PRKCB) , Q05655 (PRKCD) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11700305
K755 Ubiquitination PhosphoSitePlus
S756 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11700305
T758 Phosphorylation P24723 (PRKCH) , P05771 (PRKCB) , P17252 (PRKCA) , Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16301335, 17384276, 17937788, ...12682249, 11700305, 18550856
T759 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 12682249, 17937788
T760 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11700305, 17937788
K765 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K174 N174 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K196 N196 Biomuta DOID:3070 / malignant glioma [ tcga ]
K328 R328 Biomuta DOID:3571 / liver cancer [ tcga ]
K379 N379 Biomuta DOID:10534 / stomach cancer [ tcga ]
K633 E633 Biomuta DOID:1612 / breast cancer [ tcga ]
Y735 C735 Biomuta DOID:4362 / cervical cancer [ tcga ]
T758 N758 Biomuta DOID:3571 / liver cancer [ icgc ]