iPTMnet Report for P05106 (ITGB3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05106 / ITB3_HUMAN
Protein Name Integrin beta-3 precursor
Gene Name Name: ITGB3
Synonyms:GP3A;
Organism Homo sapiens (Human)

PRO ID PR:P05106
DAG View
PRO Name integrin beta-3 (human)
Definition An integrin beta-3 that is encoded in the genome of human.
Short Label hITGB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05106 (ITGB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K67 Ubiquitination PhosphoSitePlus
N125 N-Glycosylation GlyGen   UniProt 16335952, 19704023, 23090970, ...19111664, 16263699, 15378069, 29671580
T208 Phosphorylation PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
N346 N-Glycosylation GlyGen   UniProt 11546839, 19111664, 19704023, ...15378069
N397 N-Glycosylation GlyGen   UniProt 11546839, 19111664, 19704023, ...15378069
S439 Phosphorylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
N478 N-Glycosylation GlyGen   UniProt 23090970, 19111664, 19704023
N585 N-Glycosylation GlyGen   UniProt 23090970, 19111664, 19704023, ...11546839
Y660 Phosphorylation PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
N680 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 11546839, ...19159218, 24190977
T767 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 10896934
Y773 Phosphorylation P12931 (SRC) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15699036, 18088087, 11723131, ...12791772, 18398066, 8631894, 27145276, 19141530
T777 Phosphorylation phospho.ELM   PhosphoSitePlus 10896934
S778 O-Glycosylation PhosphoSitePlus
S778 Phosphorylation IntAct   PhosphoSitePlus 33436498
T779 Phosphorylation O15530 (PDPK1) , P31749 (AKT1) phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 10896934
T784 O-Glycosylation PhosphoSitePlus
T784 Phosphorylation PhosphoSitePlus
Y785 Phosphorylation P43405 (SYK) , P12931 (SRC) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18088087, 11723131, 18398066, ...8631894, 33436498, 27145276
Site PTM Type PTM Enzyme Score Source PMID
N125 N-Glycosylation PRO 29671580
Y773 Phosphorylation P12931 (SRC) HPRD 11723131, 18088087
T779 Phosphorylation O15530 (PDPK1) , P31749 (AKT1) , Q15118 (PDK1) HPRD 18578522, 10896934
Y785 Phosphorylation P12931 (SRC) HPRD 11723131, 18088087
Site PTM Type PTM Enzyme Score Source PMID
K764 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048069 (hITGB3/SigPep-/Phos:1) pT779 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P98082 (DAB2) S24 P05106 (ITGB3) unknown eFIP 15280374


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S439 F439 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
T767 K767 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y773 H773 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S778 C778 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T784 M784 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]