iPTMnet Report for P05091 (ALDH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05091 / ALDH2_HUMAN
Protein Name Aldehyde dehydrogenase, mitochondrial precursor
Gene Name Name: ALDH2
Synonyms:ALDM;
Organism Homo sapiens (Human)

PRO ID PR:P05091
DAG View
PRO Name aldehyde dehydrogenase, mitochondrial (human)
Definition An aldehyde dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hALDH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05091 (ALDH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K81 Acetylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
R147 Methylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
R172 Methylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
K355 Acetylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
K368 Acetylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K369 Acetylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
C386 Methylation IEDB 31844290
Y396 Phosphorylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S480 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S91 L91 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y148 H148 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y149 C149 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R172 S172 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T356 N356 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K368 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T376 M376 Biomuta DOID:184 / bone cancer [ cosmic ]
K383 M383 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K383 N383 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T503 S503 Biomuta DOID:4159 / skin cancer [ cosmic ]
K511 T511 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]