iPTMnet Report for P05067 (APP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05067 / A4_HUMAN
Protein Name Amyloid-beta precursor protein precursor
Gene Name Name: APP
Synonyms:A4;
Organism Homo sapiens (Human)

PRO ID PR:P05067
DAG View
PRO Name amyloid-beta precursor protein (human)
Definition An amyloid-beta precursor protein that is encoded in the genome of human.
Short Label hAPP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05067 (APP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T22 O-Glycosylation GlyGen 30459171
K60 Ubiquitination PhosphoSitePlus
T107 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y115 Phosphorylation PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
C158 Methylation IEDB 31844290
K178 Acetylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus   UniProt 8999878
S206 Phosphorylation PhosphoSitePlus   UniProt 8999878
T276 O-Glycosylation GlyGen 25813380
T279 O-Glycosylation GlyGen 25813380
T280 O-Glycosylation GlyGen 25813380
T352 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T353 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K363 Ubiquitination PhosphoSitePlus
T366 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T367 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S370 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T371 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
Y378 O-Glycosylation GlyGen 25813380
T381 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T381 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus   UniProt 26091039
R468 Methylation PhosphoSitePlus
Y497 Phosphorylation UniProt 26091039
N542 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 24190977
N571 N-Glycosylation GlyGen 24190977
T600 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T633 O-Glycosylation GlyGen   UniProt 25813380, 21712440, 22576872
T651 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 25813380, 21712440, ...22576872
T652 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 30459171, 25813380, 21712440, ...23584533, 22576872
S656 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 25813380, 21712440
T659 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 30459171, 25813380, ...22576872
T663 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 25813380, 21712440, ...22576872
S667 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 25813380, 21712440, ...22576872
K670 Sumoylation PhosphoSitePlus
S679 Methylation PhosphoSitePlus
S679 O-Glycosylation GlyGen 25813380
S679 Phosphorylation PhosphoSitePlus
Y681 O-Glycosylation GlyGen 22576872
K687 Acetylation PhosphoSitePlus
S697 Methylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
K699 Acetylation PhosphoSitePlus
K724 Acetylation PhosphoSitePlus
K725 Acetylation PhosphoSitePlus
Y728 Phosphorylation PhosphoSitePlus
T729 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
T743 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14970211, 8764598, 9109675, ...24610780, 15178331, 8131745, 24275569, 12917434, 28720718
T743 Phosphorylation P06493 (CDK1) PhosphoSitePlus 8131745
T743 Phosphorylation P45983 (MAPK8) neXtProt   Signor 12917434, 24610780, 14970211
T743 Phosphorylation P45984 (MAPK9) neXtProt 14970211
T743 Phosphorylation P53779 (MAPK10) neXtProt   Signor 24610780, 14970211
T743 Phosphorylation Q96SN8 (CDK5RAP2) Signor 15178331
K751 Ubiquitination PhosphoSitePlus
Y757 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 11877420, 18083107, 11279131, ...18089558, 21849536
Y757 Phosphorylation P00519 (ABL1) neXtProt 11279131
Y757 Phosphorylation P04629 (NTRK1) neXtProt 21849536
Y757 Phosphorylation P06241 (FYN) PhosphoSitePlus 18089558
T761 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K763 Sumoylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S441 Phosphorylation HPRD 18702456, 19664994, 20068231
T743 Phosphorylation HPRD 8764598, 15178331, 10936190
T743 Phosphorylation P49841 (GSK3B) HPRD 8764598, 15178331, 10936190
T743 Phosphorylation Q00535 (CDK5) HPRD 8764598, 15178331, 10936190
Y757 Phosphorylation HPRD 19901323, 11279131
Y762 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S198 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T291 O-Glycosylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
S366 Phosphorylation HPRD 18702456, 19664994, 20068231
T576 O-Glycosylation PhosphoSitePlus
K587 Sumoylation PhosphoSitePlus
K595 Sumoylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus 24305806
T654 Phosphorylation O75116 (ROCK2) PhosphoSitePlus 24305806
S655 Phosphorylation PhosphoSitePlus
T668 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 14970211, 8764598, 16554819, ...10936190, 15944381, 11146006, 15178331
T668 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 14970211
T668 Phosphorylation P45984 (MAPK9) PhosphoSitePlus 14970211
T668 Phosphorylation P49841 (GSK3B) HPRD 8764598, 15178331, 10936190
T668 Phosphorylation P53779 (MAPK10) PhosphoSitePlus 11146006, 15944381, 14970211
T668 Phosphorylation Q00535 (CDK5) neXtProt 10936190
T668 Phosphorylation Q9Y5Z0 (BACE2) HPRD 8764598, 15178331, 10936190
S675 Phosphorylation PhosphoSitePlus
Y682 Phosphorylation HPRD   PhosphoSitePlus 19901323, 11279131
Y687 Phosphorylation HPRD   PhosphoSitePlus 18083107
Site PTM Type PTM Enzyme Score Source PMID
S422 Phosphorylation HPRD 18702456, 19664994, 20068231
T710 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
T724 Phosphorylation HPRD   PhosphoSitePlus 8764598, 15178331, 10936190
T724 Phosphorylation P49841 (GSK3B) HPRD 8764598, 15178331, 10936190
T724 Phosphorylation Q00535 (CDK5) HPRD 8764598, 15178331, 10936190
Y738 Phosphorylation HPRD   PhosphoSitePlus 19901323, 11279131
Y743 Phosphorylation HPRD   PhosphoSitePlus 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T22 N22 Biomuta DOID:3571 / liver cancer [ cosmic ]
C158 Y158 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C158 R158 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K178 R178 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S206 L206 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ]
S206 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K363 E363 Biomuta DOID:363 / uterine cancer [ icgc ]
S366 Y366 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K393 E393 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S422 Y422 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S441 Y441 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
N542 I542 Biomuta DOID:4159 / skin cancer [ cosmic ]
N571 K571 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T633 S633 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T652 A652 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
T654 A654 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S655 Y655 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S655 F655 Biomuta DOID:363 / uterine cancer [ icgc ]
S679 L679 Biomuta DOID:1612 / breast cancer [ cosmic ]
S679 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T710 A710 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S711 F711 Biomuta DOID:363 / uterine cancer [ icgc ]
S711 Y711 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T729 A729 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S730 Y730 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S730 F730 Biomuta DOID:363 / uterine cancer [ icgc ]
K763 R763 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K763 E763 Biomuta DOID:9256 / colorectal cancer [ cosmic ]