Protein Information

Cytoscape View


UniProt AC / UniProt ID P05060 / SCG1_HUMAN
Protein Name Secretogranin-1 precursor
Gene Name Name: CHGB
Synonyms:SCG1;
Organism Homo sapiens (Human)

PRO ID PR:P05060
DAG View
PRO Name secretogranin-1 (human)
Definition A secretogranin-1 that is encoded in the genome of human.
Short Label hCHGB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05060 (CHGB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
S130 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18702456, 26091039
S140 Phosphorylation PhosphoSitePlus
S149 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18702456, 16807684, 14997482
Y173 Phosphorylation PhosphoSitePlus
S182 Phosphorylation HPRD   PhosphoSitePlus 18702456
S183 Phosphorylation HPRD   PhosphoSitePlus 18702456
S225 Phosphorylation UniProt 26091039
S245 Phosphorylation PhosphoSitePlus
S259 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18702456, 16807684
S263 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18702456, 16807684, 20187088
T271 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S301 Phosphorylation HPRD   PhosphoSitePlus 20187088
S311 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18702456, 16807684
N315 N-Glycosylation GlyGen 29741879
S317 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus   UniProt 16807684
Y341 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus   UniProt 26091039
S377 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18702456, 26091039, 24275569
S380 Phosphorylation PhosphoSitePlus   UniProt 26091039
S391 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus   UniProt 26091039
S405 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18702456, 16807684, 24275569, ...14997482
Y429 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
Y526 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
K598 Acetylation PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
S617 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18702456, 16807684
Y624 Phosphorylation PhosphoSitePlus
S626 Phosphorylation HPRD   PhosphoSitePlus 18702456


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S46 L46 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S93 T93 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S182 I182 Biomuta DOID:363 / uterine cancer [ tcga ]
S391 G391 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S432 F432 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S577 Y577 Biomuta DOID:1612 / breast cancer [ tcga ]
Y613 C613 Biomuta DOID:1324 / lung cancer [ tcga ]