iPTMnet Report for P04921 (GYPC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04921 / GLPC_HUMAN
Protein Name Glycophorin-C
Gene Name Name: GYPC
Synonyms:GLPC,GPC;
Organism Homo sapiens (Human)

PRO ID PR:P04921
DAG View
PRO Name glycophorin-C (human)
Definition A glycophorin-C that is encoded in the genome of human.
Short Label hGYPC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04921 (GYPC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 O-Glycosylation GlyGen   UniProt 7106126, 3571235
T4 O-Glycosylation GlyGen   UniProt 7106126, 3571235
S6 O-Glycosylation GlyGen   UniProt 7106126, 3571235
N8 N-Glycosylation GlyGen   UniProt 7106126
S9 O-Glycosylation GlyGen   UniProt 7106126
T10 O-Glycosylation GlyGen   UniProt 7106126
S15 O-Glycosylation GlyGen   UniProt 30459171, 7106126, 3571235
S24 O-Glycosylation GlyGen   UniProt 7106126, 3571235
S26 O-Glycosylation GlyGen   UniProt 7106126, 3571235
T27 O-Glycosylation GlyGen   UniProt 7106126, 3571235
T28 O-Glycosylation GlyGen   UniProt 7106126, 3571235
T31 O-Glycosylation GlyGen   UniProt 30459171, 7106126, 3571235
T32 O-Glycosylation GlyGen   UniProt 7106126, 3571235
T33 O-Glycosylation GlyGen   UniProt 30459171, 7106126, 3571235
S42 O-Glycosylation GlyGen   UniProt 30459171, 7106126, 3571235, ...22171320
K97 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus   UniProt 19690332
S122 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y126 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 M4 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
N8 S8 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T10 M10 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T27 I27 Biomuta DOID:4159 / skin cancer [ cosmic ]
S42 F42 Biomuta DOID:1324 / lung cancer [ cosmic ]
S104 R104 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S122 R122 Biomuta DOID:3571 / liver cancer [ cosmic ]
S122 N122 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y126 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y126 D126 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]