iPTMnet Report for P04899 (GNAI2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04899 / GNAI2_HUMAN
Protein Name Guanine nucleotide-binding protein G(i) subunit alpha-2
Gene Name Name: GNAI2
Synonyms:GNAI2B;
Organism Homo sapiens (Human)

PRO ID PR:P04899
DAG View
PRO Name guanine nucleotide-binding protein G(i) subunit alpha-2 (human)
Definition A guanine nucleotide-binding protein G(i) subunit alpha-2 that is encoded in the genome of human.
Short Label hGNAI2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04899 (GNAI2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 22223895, 25255805, 25807930
S6 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...25367160, 29351928, 35132862
S16 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...25367160, 29351928, 35132862
K17 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus 20043990
S44 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus 20043990
K46 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
C66 Methylation IEDB 31844290
Y69 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S111 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...25367160, 29351928, 35132862
T113 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...25367160, 29351928, 35132862
S125 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...25367160, 29351928, 35132862
S144 Phosphorylation PhosphoSitePlus 20043990
S144 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus 20043990
Y147 Phosphorylation PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
C225 Methylation IEDB 31844290
K249 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
C255 Methylation IEDB 31844290
K272 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus 20043990
S302 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus 20043990
Y303 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y69 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K46 E46 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y155 H155 Biomuta DOID:3571 / liver cancer [ cosmic ]
K193 N193 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y303 * Biomuta DOID:10283 / prostate cancer [ cosmic ]