iPTMnet Report for P04839 (CYBB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04839 / CY24B_HUMAN
Protein Name Cytochrome b-245 heavy chain
Gene Name Name: CYBB
Synonyms:NOX2;
Organism Homo sapiens (Human)

PRO ID PR:P04839
DAG View
PRO Name cytochrome b-245 heavy chain (human)
Definition A cytochrome b-245 heavy chain that is encoded in the genome of human.
Short Label hCYBB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04839 (CYBB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y41 Phosphorylation PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
N122 N-Glycosylation GlyGen 24190977
N132 N-Glycosylation GlyGen   UniProt 19159218, 24190977
N133 N-Glycosylation GlyGen 24190977
N149 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
N154 N-Glycosylation GlyGen 24190977
Y168 Phosphorylation PhosphoSitePlus
N240 N-Glycosylation GlyGen   UniProt 19159218, 24190977
K253 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y41 C41 Biomuta DOID:363 / uterine cancer [ icgc ]
N122 D122 Biomuta DOID:363 / uterine cancer [ cosmic ]
N240 D240 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N240 I240 Biomuta DOID:1319 / brain cancer [ cosmic ]
K253 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K548 Q548 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]