iPTMnet Report for P04818 (TYMS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04818 / TYSY_HUMAN
Protein Name Thymidylate synthase
Gene Name Name: TYMS
Synonyms:TS;ORFNames:OK/SW-cl.29;
Organism Homo sapiens (Human)

PRO ID PR:P04818
DAG View
PRO Name thymidylate synthase (human)
Definition A thymidylate synthase that is encoded in the genome of human.
Short Label hTYMS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04818 (TYMS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S120 Phosphorylation PhosphoSitePlus
S124 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) PhosphoSitePlus 20199796
Y135 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
C195 Methylation IEDB 31844290
C199 Methylation IEDB 31844290
C210 Methylation IEDB 31844290
T234 O-Glycosylation PhosphoSitePlus
T241 O-Glycosylation PhosphoSitePlus
T251 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 34845374, 34725712, ...28510447
K278 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K287 Sumoylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K292 Sumoylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
T306 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 34845374, 34725712, ...28510447
K308 Sumoylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 20068231
Y153 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S124 F124 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T170 I170 Biomuta DOID:4159 / skin cancer [ cosmic ]
C195 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T234 A234 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T241 K241 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]