Protein Information

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UniProt AC / UniProt ID P04792 / HSPB1_HUMAN
Protein Name Heat shock protein beta-1
Gene Name Name: HSPB1
Synonyms:HSP27,HSP28;
Organism Homo sapiens (Human)

PRO ID PR:P04792
DAG View
PRO Name heat shock protein beta-1 (human)
Definition A heat shock protein beta-1 that is encoded in the genome of human.
Short Label hHSPB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04792 (HSPB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus   UniProt 24129315
S15 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21157431, 18720982, 21999932, ...19593530, 17916631, 19562805, 21575178, 30780033, 10383393, 21364669, 23950959, 22911792, 17576778, 16964243, 15731106, 18691976, 8774846, 23186163, 18212344, 20230923, 15682460, 18440775, 16565220, 8843730, 15302935, 9628874, 20626350, 24275569, 15819993, 25699602, 21245386, 23900529, 24699855, 18088087, 24182452, 18767875, 21989268, 20058876, 19007248, 8626550, 19651622, 25569678, 12096113, 14717697, 26887051, 15236192, 17367746, 20178975, 17081983, 1332886, 19664994, 29699584, 20600103, 17697330, 25086905, 18669648, 19411251, 19166925, 28460458, 20166139, 11383510, 25710824, 28850076, 20068231
S15 Phosphorylation P23443 (RPS6KB1) Signor 19593530
S15 Phosphorylation P49137 (MAPKAPK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19651622, 18691976, 18088087, ...18212344, 20230923, 1332886, 18767875, 19664994, 19007248, 16565220, 10383393, 19562805, 18669648, 11383510, 20626350, 20058876, 20166139, 20068231
S15 Phosphorylation Q05655 (PRKCD) neXtProt 15731106
S15 Phosphorylation Q13976-2 (PRKG1) PhosphoSitePlus 11383510
S15 Phosphorylation Q16644 (MAPKAPK3) HPRD   neXtProt 18691976, 18088087, 18212344, ...20230923, 1332886, 18767875, 21575178, 19007248, 8626550, 19651622, 19664994, 18669648, 20068231, 20058876, 20166139, 16565220, 19562805
S15 Phosphorylation Q8IW41 (MAPKAPK5) neXtProt 9628874, 21575178, 19166925
R20 Methylation PhosphoSitePlus
Y23 Phosphorylation PhosphoSitePlus
S26 Phosphorylation HPRD   PhosphoSitePlus 20068231
R37 Methylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
R56 Methylation PhosphoSitePlus
S65 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 20068231, ...19007248
Y73 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S78 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21157431, 22647853, 21999932, ...19593530, 12367505, 21575178, 25364415, 10383393, 29864522, 21364669, 23900529, 22911792, 17576778, 20497126, 8843730, 8774846, 23186163, 18212344, 18688712, 15832340, 18440775, 25446109, 25710824, 29729335, 17069861, 21338617, 23026841, 24275569, 25086905, 25699602, 19166925, 9628874, 8307152, 27187380, 24182452, 18767875, 15976317, 20058876, 8626550, 24308965, 25569678, 26046355, 11383510, 30780033, 26887051, 19296652, 1730670, 20178975, 15236192, 17367746, 12096113, 26867010, 17081983, 23382286, 11912188, 1332886, 14715258, 17949744, 15302935, 29699584, 20600103, 22116673, 17697330, 20626350, 20234090, 19411251, 20640477, 28460458, 14717697, 21245386, 23112078, 20068231, 22974980
S78 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 11383510
S78 Phosphorylation P23443 (RPS6KB1) Signor 19593530
S78 Phosphorylation P49137 (MAPKAPK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18212344, 12367505, 1332886, ...18767875, 20058876, 10383393, 20626350, 11383510, 20068231
S78 Phosphorylation P51812 (RPS6KA3) neXtProt 20234090
S78 Phosphorylation Q13237 (PRKG2) Signor 19593530
S78 Phosphorylation Q13976-2 (PRKG1) PhosphoSitePlus   Signor 11383510, 19593530
S78 Phosphorylation Q16644 (MAPKAPK3) HPRD   neXtProt 18212344, 1332886, 18767875, ...20058876, 8626550, 21575178, 20068231
S78 Phosphorylation Q8IW41 (MAPKAPK5) neXtProt 9628874, 21575178, 19166925
S78 Phosphorylation Q9UBS0 (RPS6KB2) PhosphoSitePlus 1730670
S82 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21157431, 21999932, 16097034, ...10383393, 26046355, 17576778, 18212344, 18440775, 19691289, 29729335, 15728188, 25699602, 19767773, 23900529, 9628874, 21989268, 17697330, 26105860, 25569678, 11383510, 1730670, 15236192, 25710824, 17081983, 19664994, 19664995, 20166139, 12740362, 28032559, 18578522, 16964243, 15302935, 21364669, 18707149, 28252832, 23950959, 22911792, 26329039, 18931701, 23852020, 11912188, 21245386, 27187380, 19411251, 20058876, 29699584, 20234090, 20600103, 23112078, 19415658, 20068231, 17924679, 27451881, 12367505, 19562805, 15682460, 8843730, 8774846, 23186163, 20661426, 21575178, 21338617, 24275569, 24882106, 19166925, 8307152, 19651622, 24816797, 26887051, 17367746, 20626350, 18669648, 17570131, 24176848, 19593530, 29864522, 20497126, 18691976, 15976317, 27890797, 16565220, 23026841, 24182452, 25086905, 29444163, 18088087, 18767875, 19007248, 8626550, 24308965, 14717697, 20178975, 26867010, 17949744, 1332886, 28460458
S82 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 11383510
S82 Phosphorylation P23443 (RPS6KB1) Signor 19593530
S82 Phosphorylation P31749 (AKT1) PhosphoSitePlus   Signor 19593530, 12740362
S82 Phosphorylation P31751 (AKT2) Signor 19593530
S82 Phosphorylation P49137 (MAPKAPK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18578522, 16964243, 12367505, ...19562805, 10383393, 18707149, 18691976, 18212344, 19691289, 16565220, 18088087, 18767875, 20058876, 19007248, 19651622, 11383510, 1332886, 19664994, 19664995, 20626350, 18669648, 20166139, 19415658, 20068231, 17924679
S82 Phosphorylation P51812 (RPS6KA3) neXtProt 20234090
S82 Phosphorylation P98161 (PKD1) phospho.ELM 15728188
S82 Phosphorylation Q13237 (PRKG2) Signor 19593530
S82 Phosphorylation Q13976-2 (PRKG1) PhosphoSitePlus   Signor 11383510, 19593530
S82 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   RLIMS-P+ 18440775, 15728188
S82 Phosphorylation Q16644 (MAPKAPK3) HPRD   neXtProt 18578522, 16964243, 19562805, ...18707149, 18691976, 18212344, 21575178, 19691289, 16565220, 18088087, 18767875, 20058876, 19007248, 8626550, 19651622, 1332886, 19664994, 19664995, 18669648, 20166139, 19415658, 20068231, 17924679
S82 Phosphorylation Q8IW41 (MAPKAPK5) neXtProt 9628874, 21575178, 19166925
S82 Phosphorylation Q9UBS0 (RPS6KB2) PhosphoSitePlus 1730670
S82 Phosphorylation Q9Y243 (AKT3) Signor 19593530
S83 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16964243, 15302935, 19007248, ...19691289, 20068231, 17081983
S86 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15731106, 23186163, 17081983, ...1332886, 15302935, 27600495, 24275569, 15819993, 16840785, 18212344
S86 Phosphorylation Q05655 (PRKCD) neXtProt 15731106
R89 Methylation PhosphoSitePlus
T91 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S98 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
T110 Phosphorylation HPRD 20068231
K112 Ubiquitination PhosphoSitePlus
T113 Phosphorylation HPRD   PhosphoSitePlus 20068231
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
T121 Phosphorylation HPRD   PhosphoSitePlus 20068231
K123 Acetylation PhosphoSitePlus   UniProt 19608861
K123 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
S135 Phosphorylation HPRD   PhosphoSitePlus 19651622
T139 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
T143 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 11383510, 19593530
T143 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 11383510
T143 Phosphorylation Q13237 (PRKG2) Signor 19593530
T143 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus   Signor 11383510, 19593530
T162 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T174 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S176 Phosphorylation PhosphoSitePlus   UniProt 22394512, 23186163
S176 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 22394512
T180 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
K198 Sumoylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S199 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19007248, ...19691289, 19651622, 18669648, 24275569, 20166139, 20068231
T202 Phosphorylation PhosphoSitePlus
K205 Acetylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047918 (hHSPB1/Phos:2) pS15,pS78,pS82 PRO
PR:000047919 (hHSPB1/Phos:3) pS78,pS82 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04792 (HSPB1) S78 P99999 (CYCS) unknown eFIP 22974980


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y23 S23 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K171 N171 Biomuta DOID:363 / uterine cancer [ tcga ]