iPTMnet Report for P04629 (NTRK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04629 / NTRK1_HUMAN
Protein Name High affinity nerve growth factor receptor precursor
Gene Name Name: NTRK1
Synonyms:MTC,TRK;
Organism Homo sapiens (Human)

PRO ID PR:P04629
DAG View
PRO Name high affinity nerve growth factor receptor (human)
Definition A high affinity nerve growth factor receptor that is encoded in the genome of human.
Short Label hNTRK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04629 (NTRK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N95 N-Glycosylation GlyGen   UniProt 17196528
N121 N-Glycosylation GlyGen   UniProt 17196528
S123 Phosphorylation PhosphoSitePlus
N188 N-Glycosylation GlyGen   UniProt 17196528
N262 N-Glycosylation GlyGen   UniProt 17196528
N281 N-Glycosylation GlyGen   UniProt 17196528
N358 N-Glycosylation GlyGen   UniProt 17196528
Y496 Phosphorylation P04629 (NTRK1) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8226808, 11159935, 8155326, ...27676246, 9099755, 15488758
Y591 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
Y676 Phosphorylation P04629 (NTRK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 8155326, 11159935, 9099755
Y680 Phosphorylation P04629 (NTRK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30808933, 8155326, 11159935, ...9099755, 15488758
Y681 Phosphorylation P04629 (NTRK1) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30808933, 8155326, 11159935, ...12237455, 9099755, 15488758
Y701 Phosphorylation P04629 (NTRK1) neXtProt   PhosphoSitePlus 18173729
Y729 Phosphorylation PhosphoSitePlus
Y757 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 8226808, 16319926
Y791 Phosphorylation P04629 (NTRK1) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 11159935, 8384556, 8155326, ...7510697, 9099755, 10092678, 15488758
Site PTM Type PTM Enzyme Score Source PMID
Y490 Phosphorylation P04629 (NTRK1) HPRD   PRO   PhosphoSitePlus 9099755, 11159935, 27655914
Y670 Phosphorylation P04629 (NTRK1) HPRD   PhosphoSitePlus 9099755, 11159935
Y674 Phosphorylation P04629 (NTRK1) HPRD   PRO   PhosphoSitePlus 9099755, 11159935, 27655914
Y675 Phosphorylation P04629 (NTRK1) HPRD   PRO   PhosphoSitePlus 9099755, 11159935, 27655914
Y751 Phosphorylation P04629 (NTRK1) HPRD   PhosphoSitePlus 9099755
Y785 Phosphorylation P04629 (NTRK1) HPRD   PhosphoSitePlus 9099755, 11159935
Site PTM Type PTM Enzyme Score Source PMID
Y460 Phosphorylation P04629 (NTRK1) HPRD 11159935
Y640 Phosphorylation HPRD 11159935
Y644 Phosphorylation HPRD 11159935
Y645 Phosphorylation HPRD 11159935
Y721 Phosphorylation HPRD 9099755
Y755 Phosphorylation P04629 (NTRK1) HPRD 11159935


P04629 (NTRK1) as PTM Enzyme



Substrate Site Score Source PMID
P04629-3 (NTRK1) Y460 HPRD 11159935
P04629-2 (NTRK1) Y490 HPRD   PhosphoSitePlus 9099755, 11159935
P04629 (NTRK1) Y496 neXtProt   PhosphoSitePlus   Signor   UniProt 9099755, 15488758, 8155326
P04629-2 (NTRK1) Y670 PhosphoSitePlus 9099755
P04629-2 (NTRK1) Y674 PhosphoSitePlus 9099755
P04629-2 (NTRK1) Y675 PhosphoSitePlus 9099755
P04629 (NTRK1) Y676 neXtProt   Signor   UniProt 8155326, 9099755
P04629 (NTRK1) Y680 neXtProt   PhosphoSitePlus   Signor   UniProt 9099755, 15488758, 8155326
P04629 (NTRK1) Y681 neXtProt   PhosphoSitePlus   Signor   UniProt 8155326, 15488758, 9099755
P04629 (NTRK1) Y701 neXtProt 18173729
P04629-2 (NTRK1) Y751 PhosphoSitePlus 9099755
P04629-3 (NTRK1) Y755 HPRD 11159935
P04629-2 (NTRK1) Y785 HPRD   PhosphoSitePlus 9099755, 11159935
P04629 (NTRK1) Y791 neXtProt   Signor   UniProt 8155326, 10092678, 7510697, ...15488758, 9099755
P05067 (APP) Y757 neXtProt 21849536
P29353-2 (SHC1) Y317 PhosphoSitePlus 12237775
P35222 (CTNNB1) Y142 PhosphoSitePlus 22558232
Q92529-2 (SHC3) Y218 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y219 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y256 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y257 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y283 PhosphoSitePlus 11791173
Q92529-2 (SHC3) Y301 PhosphoSitePlus 11791173


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048644 (hNTRK1/SigPep-/Phos:1) pY496,pY676,pY680,pY681,pY791 PRO
PR:000049957 (hNTRK1/iso:TrkA-I/mature/NGlycoPhos:1) pY490 PRO 27655914
PR:000049958 (hNTRK1/iso:TrkA-I/mature/NGlycoPhos:2) pY674,pY675 PRO 27655914


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S672 I672 Biomuta DOID:363 / uterine cancer [ icgc ]
Y701 H701 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y729 H729 Biomuta [ cosmic ]
Y785 H785 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y785 N785 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y791 H791 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y791 N791 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]