iPTMnet Report for P04626 (ERBB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04626 / ERBB2_HUMAN
Protein Name Receptor tyrosine-protein kinase erbB-2 precursor
Gene Name Name: ERBB2
Synonyms:HER2,MLN19,NEU,NGL;
Organism Homo sapiens (Human)

PRO ID PR:P04626
DAG View
PRO Name receptor tyrosine-protein kinase erbB-2 (human)
Definition A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human.
Short Label hERBB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04626 (ERBB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
N68 N-Glycosylation GlyGen   UniProt 20696930
N124 N-Glycosylation GlyGen 29741879
T127 O-Glycosylation GlyGen 30459171
K150 Ubiquitination PhosphoSitePlus
K175 Methylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus   UniProt 23186163
N187 N-Glycosylation GlyGen 23090970, 29741879, 24190977
S196 Phosphorylation PhosphoSitePlus
N259 N-Glycosylation GlyGen   UniProt 20696930, 23090970, 19299620, ...24190977, 29741879, 15093539
N530 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19299620, ...15093539, 24190977
N571 N-Glycosylation GlyGen   UniProt 23090970, 20696930, 24190977
N629 N-Glycosylation GlyGen 23090970, 29741879, 24190977
T686 Phosphorylation P17252 (PRKCA) , Q13237 (PRKG2) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26676300, 18799465, 23254288, ...9855018, 8702975
T701 Phosphorylation PhosphoSitePlus   RLIMS-P 33037285, 28632938
S703 Phosphorylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
T733 Phosphorylation PhosphoSitePlus
Y735 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 18083107, 16729043
K736 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
Y772 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
T875 Phosphorylation PhosphoSitePlus
Y877 Phosphorylation P04626 (ERBB2) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 20818175, 15163624, 32584853, ...23318431, 16785428, 30057418, 15300809, 22676470, 17237269, 25346782, 19289058, 23212450, 31492560, 25853726, 32815546, 18700973, 32381043, 20332114, 23843458, 22549178, 25596742, 15695410, 28459445, 19760502
K883 Ubiquitination PhosphoSitePlus
K887 Ubiquitination PhosphoSitePlus
T900 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 26143491
Y923 Phosphorylation IntAct   PhosphoSitePlus 16729043
K937 Ubiquitination PhosphoSitePlus
T948 Phosphorylation PhosphoSitePlus
S974 Phosphorylation PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
S998 O-Glycosylation GlyGen 30237853
S998 Phosphorylation PhosphoSitePlus
S1002 Phosphorylation PhosphoSitePlus
T1003 Phosphorylation PhosphoSitePlus
Y1005 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P 16729043, 29490608, 30884851
S1007 Phosphorylation PhosphoSitePlus
Y1023 Phosphorylation P04626 (ERBB2) IntAct   neXtProt   PRO   PhosphoSitePlus   Signor 1706616, 16273093
S1049 Phosphorylation PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
T1052 Phosphorylation PhosphoSitePlus
S1054 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18669648, 24275569
T1060 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
S1073 Phosphorylation PhosphoSitePlus   RLIMS-P 24263233
S1078 Phosphorylation PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1100 Phosphorylation PhosphoSitePlus
T1103 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y1112 Phosphorylation P04626 (ERBB2) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15210733, 29490608, 27050377, ...15163624, 30884851, 23027125, 27469139, 1706616, 10910043, 25081058, 27134172
S1113 Phosphorylation RLIMS-P 11330837, 23254288
S1122 Phosphorylation PhosphoSitePlus
T1124 Phosphorylation PhosphoSitePlus
Y1127 Phosphorylation PhosphoSitePlus   RLIMS-P 29490608, 30884851
T1132 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1139 Phosphorylation P04626 (ERBB2) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 15210733, 31831814, 29490608, ...9079677, 10372802, 16371159, 12061724, 30884851, 23027125, 1706616, 16624867, 21966491, 11500516, 16729043, 11940572, 16273093, 27134172
S1151 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 35637411, 24275569
T1166 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1172 Phosphorylation Q9UQM7 (CAMK2A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 10347170, 8700533
S1174 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus 12824184, 17145757
Y1196 Phosphorylation P04626 (ERBB2) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29490608, 27531070, 24810047, ...15156151, 30884851, 21966491, 25081058, 26143491, 11500516, 16729043, 16273093, 32381043, 27134172
T1198 Phosphorylation PhosphoSitePlus
S1214 Phosphorylation PhosphoSitePlus
Y1221 Phosphorylation P04626 (ERBB2) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 19239686, 25193864, 19754954, ...21966491, 25889497, 28903399, 28808311, 22561705, 32640677, 26490994, 18682844, 21791570, 29050229, 11500516, 31635022, 32117718, 26625311, 16273093, 25792810, 23254288, 31831814, 21364123, 1706616, 28915606, 26143491, 24958351
Y1222 Phosphorylation P04626 (ERBB2) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10372802, 19239686, 11953857, ...25193864, 19754954, 15156151, 21966491, 25889497, 28903399, 11940572, 22561705, 32640677, 26490994, 18682844, 21791570, 29050229, 11500516, 16729043, 31635022, 32117718, 26625311, 16273093, 9637788, 21840311, 25792810, 23254288, 31831814, 21364123, 1706616, 28915606, 26143491, 24958351
S1235 Phosphorylation PhosphoSitePlus
T1236 Phosphorylation PhosphoSitePlus
T1240 Phosphorylation PhosphoSitePlus
T1242 Phosphorylation PhosphoSitePlus
Y1248 Phosphorylation P00533 (EGFR) , P04626 (ERBB2) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 15210733, 26114632, 20201928, ...21712485, 24801752, 15163624, 30884851, 23749689, 23212450, 19491269, 29348142, 24835103, 27356767, 15300809, 12748185, 27416801, 32640677, 19082476, 29490608, 22892392, 17525746, 18687633, 19094209, 21209853, 16414259, 9334404, 12122014, 17490486, 16624867, 24278211, 11500516, 16729043, 17206861, 25344208, 12354693, 32117718, 33037285, 20386540, 17554007, 12386815, 18781152, 25081058, 28243327, 30967373, 21034468, 32815546, 18700973, 18264744, 16273093, 20010870, 27134172, 9637788, 25686822, 17081983, 27345410, 21499296, 7624146, 25773930, 28639750, 1706616, 29491709, 15695410, 28348404, 18945363, 26143491, 18320059, 9461599, 28947957
Site PTM Type PTM Enzyme Score Source PMID
Y735 Phosphorylation HPRD 16729043
Y877 Phosphorylation HPRD 16785428
Y923 Phosphorylation HPRD 16729043
S998 Phosphorylation HPRD 20068231
Y1005 Phosphorylation HPRD 16729043
Y1023 Phosphorylation P04626 (ERBB2) HPRD 11500516, 16729043, 1706616
S1054 Phosphorylation HPRD 18691976, 18669648, 19664994, ...20068231
S1107 Phosphorylation HPRD 20068231
S1134 Phosphorylation HPRD 18669648
Y1139 Phosphorylation P04626 (ERBB2) HPRD 10372802, 16729043, 1706616
S1151 Phosphorylation HPRD 18669648
Y1196 Phosphorylation HPRD 11500516, 16729043
Y1221 Phosphorylation P04626 (ERBB2) HPRD 11500516, 1706616
Y1222 Phosphorylation P04626 (ERBB2) HPRD 10372802, 16729043, 1706616
Y1248 Phosphorylation P00533 (EGFR) , P04626 (ERBB2) HPRD 1706616, 17389395, 17426253, ...12354693
Site PTM Type PTM Enzyme Score Source PMID
S968 Phosphorylation HPRD 20068231
Y993 Phosphorylation P04626 (ERBB2) HPRD 11500516, 1706616
S1024 Phosphorylation HPRD 18691976, 18669648, 19664994, ...20068231
S1077 Phosphorylation HPRD 20068231
S1104 Phosphorylation HPRD 18669648
Y1109 Phosphorylation P04626 (ERBB2) HPRD 10372802, 1706616
S1121 Phosphorylation HPRD 18669648
Y1166 Phosphorylation HPRD 11500516
Y1191 Phosphorylation P04626 (ERBB2) HPRD 11500516, 1706616
Y1192 Phosphorylation P04626 (ERBB2) HPRD 10372802, 1706616
Y1218 Phosphorylation P04626 (ERBB2) , P00533 (EGFR) HPRD 11500516, 17426253, 17389395


P04626 (ERBB2) as PTM Enzyme



Substrate Site Score Source PMID
O43157 (PLXNB1) Y1708 PhosphoSitePlus 19805522
O43157 (PLXNB1) Y1732 PhosphoSitePlus 19805522
P00338 (LDHA) Y10 RLIMS-P+ 28218905
P00533-1 (EGFR) Y1069 HPRD 17016520, 18691976, 17389395, ...9363897, 18669648, 16799092, 10635327
P04626 (ERBB2) Y877 PhosphoSitePlus 16785428
P04626-5 (ERBB2) Y993 HPRD 11500516, 1706616
P04626-1 (ERBB2) Y1023 HPRD   neXtProt   PhosphoSitePlus   Signor 11500516, 16729043, 1706616
P04626-5 (ERBB2) Y1109 HPRD 10372802, 1706616
P04626 (ERBB2) Y1112 PhosphoSitePlus   Signor 1706616
P04626 (ERBB2) Y1139 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11500516, 1706616, 16729043, ...10372802
P04626-5 (ERBB2) Y1191 HPRD 11500516, 1706616
P04626-5 (ERBB2) Y1192 HPRD 10372802, 1706616
P04626 (ERBB2) Y1196 phospho.ELM   PhosphoSitePlus   Signor 15156151, 11500516
P04626-5 (ERBB2) Y1218 HPRD 11500516, 17426253, 17389395
P04626 (ERBB2) Y1221 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11500516, 1706616
P04626 (ERBB2) Y1222 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10372802, 9637788, 15156151, ...1706616, 11500516, 16729043
P04626 (ERBB2) Y1248 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 9637788, 17389395, 17081983, ...17426253, 7624146, 1706616, 11500516, 12354693
P06493 (CDK1) Y15 neXtProt   PhosphoSitePlus   Signor 12049736
P35222 (CTNNB1) Y654 neXtProt   PhosphoSitePlus 14517306
Q96N67 (DOCK7) Y1257 PhosphoSitePlus   Signor 18426980
Q9BXH1 (BBC3) Y58 PhosphoSitePlus 24236056
Q9BXH1 (BBC3) Y152 PhosphoSitePlus 24236056
Q9BXH1 (BBC3) Y172 PhosphoSitePlus 24236056


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047318 (hERBB2/SigPep-/Phos:2) pY1023,pY1112,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047319 (hERBB2/SigPep-/Phos:3) pY1023,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047320 (hERBB2/SigPep-/Phos:4) pY877 PRO
PR:000047321 (hERBB2/SigPep-/Phos:5) pY877,pY1023,pY1112,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047322 (hERBB2/SigPep-/Phos:6) pY877,pY1023,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047323 (hERBB2/SigPep-/PhosTyr+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04626 (ERBB2) T701 P00533 (EGFR) unknown eFIP 28632938
Phosphorylation P04626 (ERBB2) Y1248 P00533 (EGFR) unknown eFIP 15163624
Phosphorylation Q92597 (NDRG1) T346 P04626 (ERBB2) unknown eFIP 31384305


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K175 E175 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K175 R175 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T182 I182 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S196 P196 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S196 F196 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T686 M686 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T686 R686 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K716 E716 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K724 N724 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S728 F728 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T733 I733 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K736 N736 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S819 F819 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K860 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T875 R875 Biomuta DOID:363 / uterine cancer [ icgc ]
T875 I875 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K937 R937 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S974 F974 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S977 T977 Biomuta DOID:363 / uterine cancer [ icgc ]
S1007 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1049 I1049 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1050 L1050 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S1050 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1051 F1051 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1077 N1077 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1078 F1078 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1103 P1103 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1103 I1103 Biomuta DOID:1612 / breast cancer [ icgc ]
S1107 N1107 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1121 L1121 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1122 P1122 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1151 L1151 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1166 I1166 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1174 F1174 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
Y1191 C1191 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1198 A1198 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1214 N1214 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
Y1221 C1221 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1242 M1242 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]