Protein Information

Cytoscape View

UniProt AC / UniProt ID P04439 / HLAA_HUMAN
Protein Name HLA class I histocompatibility antigen, A alpha chain precursor
Gene Name Name: HLA-A
Organism Homo sapiens (Human)

PRO ID PR:P04439
DAG View
PRO Name HLA class I histocompatibility antigen, A-3 alpha chain (human)
Definition An HLA class I histocompatibility antigen A alpha chain (human) that belongs to allele group 3.
Short Label hHLA-A*3
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species

P04439 (HLA-A) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K92 Ubiquitination PhosphoSitePlus
N110 N-Glycosylation UniProt 19159218
K145 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
S336 Phosphorylation P10644 (PRKAR1A) HPRD 6333425
S337 Phosphorylation P10644 (PRKAR1A) HPRD 6333425
K340 Ubiquitination PhosphoSitePlus
S343 Phosphorylation P10644 (PRKAR1A) HPRD   PhosphoSitePlus   UniProt 6333425, 24275569
Y344 Phosphorylation P12931 (SRC) HPRD   PhosphoSitePlus   UniProt 6304688, 6333425, 24275569
T345 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus   UniProt 24275569
S350 Phosphorylation PhosphoSitePlus   UniProt 24275569
S352 Phosphorylation PhosphoSitePlus   UniProt 24275569
S356 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S359 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   UniProt 23186163, 2941417, 24275569
T361 Phosphorylation PhosphoSitePlus
C363 S-Nitrosylation dbSNO 26338901
K364 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y147 C147 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y147 D147 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K168 Q168 Biomuta DOID:4159 / skin cancer [ icgc ]
T345 S345 Biomuta DOID:3571 / liver cancer [ icgc ]