iPTMnet Report for P04439 (HLA-A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04439 / HLAA_HUMAN
Protein Name HLA class I histocompatibility antigen, A alpha chain precursor
Gene Name Name: HLA-A
Synonyms:HLAA;
Organism Homo sapiens (Human)

PRO ID PR:P04439
DAG View
PRO Name HLA class I histocompatibility antigen, A alpha chain (human)
Definition An MHC class I histocompatibility antigen A alpha chain that is encoded in the genome of human.
Short Label hHLA-A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04439 (HLA-A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
R68 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
N110 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
S112 O-Glycosylation GlyGen 27655845, 28510447, 11019912, ...29351928
Y123 Phosphorylation PhosphoSitePlus
R135 Methylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
R155 Methylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
K267 Acetylation PhosphoSitePlus
K267 Methylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y344 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor   UniProt 6304688, 24275569
T345 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus   UniProt 24275569
S350 Phosphorylation PhosphoSitePlus   UniProt 24275569
S352 Phosphorylation PhosphoSitePlus   UniProt 24275569
S356 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S359 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T361 Phosphorylation PhosphoSitePlus
C363 Methylation IEDB 31844290
C363 S-Nitrosylation dbSNO 26338901
K364 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S336 Phosphorylation P10644 (PRKAR1A) HPRD 6333425
S337 Phosphorylation P10644 (PRKAR1A) HPRD 6333425
S343 Phosphorylation P10644 (PRKAR1A) HPRD 6333425
Y344 Phosphorylation P12931 (SRC) HPRD 6333425, 6304688
S359 Phosphorylation P17252 (PRKCA) HPRD 2941417


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R68 S68 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R68 K68 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y83 C83 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y83 N83 Biomuta DOID:1324 / lung cancer [ cosmic ]
T104 I104 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
Y123 F123 Biomuta [ cosmic ]
Y123 C123 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
R135 C135 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
Y137 C137 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y147 C147 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y147 D147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R155 C155 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T167 I167 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K168 Q168 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y195 C195 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y195 H195 Biomuta [ cosmic ]
Y195 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T202 M202 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
K210 R210 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
K292 E292 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T345 S345 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T345 I345 Biomuta DOID:9256 / colorectal cancer [ cosmic ]