iPTMnet Report P04439 HLA-A

Protein Information

UniProt AC / UniProt ID	P04439 / HLAA_HUMAN
Protein Name	HLA class I histocompatibility antigen, A alpha chain precursor
Gene Name	Name: HLA-A Synonyms:HLAA;
Organism	Homo sapiens (Human)

PRO ID	PR:P04439 DAG View
PRO Name	HLA class I histocompatibility antigen, A alpha chain (human)
Definition	An MHC class I histocompatibility antigen A alpha chain that is encoded in the genome of human.
Short Label	hHLA-A
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P04439 (HLA-A) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T8 Y51 R68 Y83 K92 T104 N110 S112 Y123 R135 Y137 K145 Y147 R155 T158 T167 K168 K170 Y195 K200 T202 K210 S219 K267 S275 K292 S337 K340 S343 Y344 T345 S349 S350 S352 S356 S359 T361 C363 K364	PTM Type Select all Acetylation Methylation N-Glycosylation O-Glycosylation Phosphorylation S-Nitrosylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen IEDB PhosphoSitePlus Signor UniProt dbSNO	PMID
T8	Phosphorylation		score1	PhosphoSitePlus
Y51	Phosphorylation		score1	PhosphoSitePlus
R68	Ubiquitination		score1	PhosphoSitePlus
Y83	Phosphorylation		score1	PhosphoSitePlus
K92	Ubiquitination		score1	PhosphoSitePlus
T104	Phosphorylation		score1	PhosphoSitePlus
N110	N-Glycosylation		score2	GlyGen UniProt	23090970, 29741879, 19159218, ...24190977
S112	O-Glycosylation		score3	GlyGen	27655845, 28510447, 11019912, ...29351928
Y123	Phosphorylation		score1	PhosphoSitePlus
R135	Methylation		score1	PhosphoSitePlus
Y137	Phosphorylation		score1	PhosphoSitePlus
K145	Ubiquitination		score1	PhosphoSitePlus
Y147	Phosphorylation		score1	PhosphoSitePlus
R155	Methylation		score1	PhosphoSitePlus
T158	Phosphorylation		score1	PhosphoSitePlus
T167	Phosphorylation		score1	PhosphoSitePlus
K168	Ubiquitination		score1	PhosphoSitePlus
K170	Acetylation		score1	PhosphoSitePlus
K170	Ubiquitination		score1	PhosphoSitePlus
Y195	Phosphorylation		score1	PhosphoSitePlus
K200	Ubiquitination		score1	PhosphoSitePlus
T202	Phosphorylation		score1	PhosphoSitePlus
K210	Ubiquitination		score1	PhosphoSitePlus
S219	Phosphorylation		score1	PhosphoSitePlus
K267	Acetylation		score1	PhosphoSitePlus
K267	Methylation		score1	PhosphoSitePlus
K267	Ubiquitination		score1	PhosphoSitePlus
S275	Phosphorylation		score1	PhosphoSitePlus
K292	Ubiquitination		score1	PhosphoSitePlus
S337	Phosphorylation		score1	PhosphoSitePlus
K340	Ubiquitination		score1	PhosphoSitePlus
S343	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
Y344	Phosphorylation	P12931 (SRC)	score4	PhosphoSitePlus Signor UniProt	6304688, 24275569
T345	Phosphorylation		score1	PhosphoSitePlus
S349	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
S350	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
S352	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
S356	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163, 24275569
S359	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163, 24275569
T361	Phosphorylation		score1	PhosphoSitePlus
C363	Methylation		score1	IEDB	31844290
C363	S-Nitrosylation		score0	dbSNO	26338901
K364	Ubiquitination		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Tyrosine By position S336 S337 S343 Y344 S359	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1 2	Source Select all HPRD	PMID
S336	Phosphorylation	P10644 (PRKAR1A)	score1	HPRD	6333425
S337	Phosphorylation	P10644 (PRKAR1A)	score1	HPRD	6333425
S343	Phosphorylation	P10644 (PRKAR1A)	score1	HPRD	6333425
Y344	Phosphorylation	P12931 (SRC)	score2	HPRD	6333425, 6304688
S359	Phosphorylation	P17252 (PRKCA)	score1	HPRD	2941417

PTM sites affected in variants

Search:

Site Select all By amino acid All Threonine All Tyrosine By position R68 Y83 T104 Y123 R135 Y137 Y147 R155 T167 K168 Y195 T202 K210 K292 T345	Variant Select all * C123 C135 C137 C147 C155 C195 C83 D147 E292 F123 H195 I104 I167 I345 K68 M202 N83 Q168 R210 S345 S68	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1793 / pancreatic cancer [ icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] [ cosmic ] [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R68	S68	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
R68	K68	Biomuta	DOID:263 / kidney cancer [ cosmic ]
Y83	C83	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y83	N83	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T104	I104	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
Y123	F123	Biomuta	[ cosmic ]
Y123	C123	Biomuta	DOID:2531 / hematologic cancer [ cosmic, icgc ]
R135	C135	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
Y137	C137	Biomuta	DOID:1793 / pancreatic cancer [ icgc ]
Y147	C147	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y147	D147	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R155	C155	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T167	I167	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K168	Q168	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y195	C195	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
Y195	H195	Biomuta	[ cosmic ]
Y195	*	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T202	M202	Biomuta	[ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
K210	R210	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
K292	E292	Biomuta	[ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T345	S345	Biomuta	[ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T345	I345	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P04439 (HLA-A)

Protein Information

Interactive Sequence View

P04439 (HLA-A) as Substrate

PTM sites affected in variants