iPTMnet Report for P04275 (VWF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04275 / VWF_HUMAN
Protein Name von Willebrand factor precursor
Gene Name Name: VWF
Synonyms:F8VWF;
Organism Homo sapiens (Human)

PRO ID PR:P04275
DAG View
PRO Name von Willebrand factor (human)
Definition A von Willebrand factor that is encoded in the genome of human.
Short Label hVWF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04275 (VWF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y119 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
N156 N-Glycosylation GlyGen 23090970, 23345538
N211 N-Glycosylation GlyGen 23090970, 23345538
Y357 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
N368 N-Glycosylation GlyGen 29391424
C388 Methylation IEDB 31844290
T485 Phosphorylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
Y610 Phosphorylation PhosphoSitePlus
N666 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...23345538
S746 O-Glycosylation GlyGen 30459171
N857 N-Glycosylation GlyGen 23090970, 29741879
N1147 N-Glycosylation GlyGen 23090970
T1255 O-Glycosylation GlyGen 30459171
T1256 O-Glycosylation GlyGen 30459171
S1263 O-Glycosylation GlyGen   UniProt 30459171, 3524673
S1338 Phosphorylation PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
Y1349 Phosphorylation PhosphoSitePlus
S1394 Phosphorylation PhosphoSitePlus
Y1400 Phosphorylation PhosphoSitePlus
T1468 O-Glycosylation GlyGen 30459171
T1477 O-Glycosylation GlyGen 30459171
N1515 N-Glycosylation GlyGen   UniProt 23090970, 17975018, 19139490, ...14760718, 29671580
S1517 Phosphorylation PhosphoSitePlus
Y1570 Phosphorylation PhosphoSitePlus
N1574 N-Glycosylation GlyGen 23090970, 26773038, 17975018, ...23345538
T1578 Phosphorylation PhosphoSitePlus
Y1584 Phosphorylation PhosphoSitePlus
S1586 Phosphorylation PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus
K1720 Ubiquitination PhosphoSitePlus
S2010 Phosphorylation PhosphoSitePlus
S2030 Phosphorylation PhosphoSitePlus
N2223 N-Glycosylation GlyGen 23090970, 29741879, 29671580
N2290 N-Glycosylation GlyGen 29391424
T2298 O-Glycosylation GlyGen 26784534, 30459171
N2357 N-Glycosylation GlyGen 23090970
N2546 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 23345538
N2585 N-Glycosylation GlyGen 23090970, 29741879, 29391424
N2635 N-Glycosylation GlyGen 23090970, 22849435
S2807 Phosphorylation PhosphoSitePlus
S2812 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N156 N-Glycosylation PRO 23345538
N211 N-Glycosylation PRO 23345538
N666 N-Glycosylation PRO 23345538
N1515 N-Glycosylation PRO 29671580
N1574 N-Glycosylation PRO 23345538
N2223 N-Glycosylation PRO 29671580
N2546 N-Glycosylation PRO 23345538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y119 H119 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y134 C134 Biomuta DOID:1324 / lung cancer [ cosmic ]
N156 H156 Biomuta DOID:3571 / liver cancer [ cosmic ]
N211 S211 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T485 S485 Biomuta DOID:263 / kidney cancer [ cosmic ]
N857 S857 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1255 I1255 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1263 L1263 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1338 L1338 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y1570 C1570 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1613 F1613 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1613 C1613 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1720 N1720 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S2010 C2010 Biomuta DOID:1324 / lung cancer [ cosmic ]
N2290 S2290 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T2298 M2298 Biomuta DOID:10534 / stomach cancer [ cosmic ]
N2635 K2635 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2807 F2807 Biomuta DOID:4159 / skin cancer [ cosmic ]