iPTMnet Report for P04259 (KRT6B)
Protein Information
UniProt AC / UniProt ID | P04259 / K2C6B_HUMAN |
Protein Name | Keratin, type II cytoskeletal 6B |
Gene Name | Name: KRT6B Synonyms:K6B,KRTL1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P04259 |
PRO Name | keratin, type II cytoskeletal 6B (human) |
Definition | A keratin, type II cytoskeletal 6B that is encoded in the genome of human. |
Short Label | hKRT6B |
Category | organism-gene |
P04259 (KRT6B) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
S5 | Phosphorylation | score1 | PhosphoSitePlus | |||
S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
R16 | Methylation | score1 | PhosphoSitePlus | |||
S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
S22 | Phosphorylation | score1 | PhosphoSitePlus | |||
R24 | Methylation | score1 | PhosphoSitePlus | |||
S31 | Phosphorylation | score1 | PhosphoSitePlus | |||
S34 | Phosphorylation | score1 | PhosphoSitePlus | |||
S37 | Phosphorylation | score1 | PhosphoSitePlus | |||
S41 | Phosphorylation | score1 | PhosphoSitePlus | |||
R42 | Methylation | score1 | PhosphoSitePlus | |||
S44 | Phosphorylation | score1 | PhosphoSitePlus | |||
S58 | Phosphorylation | score1 | PhosphoSitePlus | |||
R59 | Methylation | score1 | PhosphoSitePlus | |||
S60 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y62 | Phosphorylation | score1 | PhosphoSitePlus | |||
S67 | Phosphorylation | score1 | PhosphoSitePlus | |||
S71 | Phosphorylation | score1 | PhosphoSitePlus | |||
S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
S80 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y83 | Phosphorylation | score1 | PhosphoSitePlus | |||
S85 | Phosphorylation | score1 | PhosphoSitePlus | |||
K168 | Ubiquitination | score1 | PhosphoSitePlus | |||
T169 | Phosphorylation | score1 | PhosphoSitePlus | |||
K173 | Acetylation | score1 | PhosphoSitePlus | |||
K173 | Methylation | score1 | PhosphoSitePlus | |||
K173 | Sumoylation | score1 | PhosphoSitePlus | |||
K173 | Ubiquitination | score1 | PhosphoSitePlus | |||
S176 | Phosphorylation | score1 | PhosphoSitePlus | |||
K180 | Acetylation | score1 | PhosphoSitePlus | |||
K180 | Ubiquitination | score1 | PhosphoSitePlus | |||
K194 | Methylation | score1 | PhosphoSitePlus | |||
Y217 | Phosphorylation | score1 | PhosphoSitePlus | |||
S237 | Phosphorylation | score1 | PhosphoSitePlus | |||
K252 | Methylation | score1 | PhosphoSitePlus | |||
K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y253 | Phosphorylation | score1 | PhosphoSitePlus | |||
K259 | Methylation | score1 | PhosphoSitePlus | |||
K259 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y278 | Phosphorylation | score1 | PhosphoSitePlus | |||
T290 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y302 | Phosphorylation | score1 | PhosphoSitePlus | |||
S332 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y341 | Phosphorylation | score1 | PhosphoSitePlus | |||
S348 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y356 | Phosphorylation | score1 | PhosphoSitePlus | |||
T358 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y360 | Phosphorylation | score1 | PhosphoSitePlus | |||
T366 | Phosphorylation | score1 | PhosphoSitePlus | |||
S393 | Phosphorylation | score1 | PhosphoSitePlus | |||
K426 | Acetylation | score1 | PhosphoSitePlus | |||
Y448 | Phosphorylation | score1 | PhosphoSitePlus | |||
K467 | Acetylation | score1 | PhosphoSitePlus | |||
R475 | Methylation | score1 | PhosphoSitePlus | |||
S540 | Phosphorylation | score1 | PhosphoSitePlus | |||
S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
S546 | Phosphorylation | score1 | PhosphoSitePlus | |||
T548 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y551 | Phosphorylation | score1 | PhosphoSitePlus | |||
S557 | Phosphorylation | score1 | PhosphoSitePlus | |||
S558 | Phosphorylation | score1 | PhosphoSitePlus | |||
S561 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S10 | G10 | Biomuta | DOID:1909 / melanoma [ tcga ] | |
R16 | Q16 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S31 | C31 | Biomuta | DOID:1612 / breast cancer [ tcga ] | |
S34 | G34 | Biomuta | DOID:3371 / chondrosarcoma [ cosmic ] | |
R42 | S42 | Biomuta | DOID:1324 / lung cancer [ tcga ] | |
S76 | T76 | Biomuta | DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ] | |
K168 | R168 | Biomuta | DOID:3571 / liver cancer [ tcga ] | |
S237 | L237 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc, tcga ] | |
S237 | * | Biomuta | DOID:3571 / liver cancer [ icgc ] | |
Y302 | C302 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S332 | N332 | Biomuta | DOID:1909 / melanoma [ icgc, tcga ] | |
S332 | T332 | Biomuta | DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ] | |
K426 | T426 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S546 | R546 | Biomuta | DOID:1909 / melanoma [ tcga ] | |
S558 | I558 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] |