iPTMnet Report for P04259 (KRT6B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04259 / K2C6B_HUMAN
Protein Name Keratin, type II cytoskeletal 6B
Gene Name Name: KRT6B
Synonyms:K6B,KRTL1;
Organism Homo sapiens (Human)

PRO ID PR:P04259
DAG View
PRO Name keratin, type II cytoskeletal 6B (human)
Definition A keratin, type II cytoskeletal 6B that is encoded in the genome of human.
Short Label hKRT6B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04259 (KRT6B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
R16 Methylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
R24 Methylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
R59 Methylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Methylation PhosphoSitePlus
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K194 Methylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K252 Methylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
K259 Methylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
R475 Methylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 G10 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R16 Q16 Biomuta DOID:363 / uterine cancer [ icgc ]
S34 G34 Biomuta DOID:184 / bone cancer [ cosmic ]
S37 F37 Biomuta DOID:4159 / skin cancer [ cosmic ]
R42 S42 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S76 T76 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K168 R168 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S237 L237 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K252 Q252 Biomuta DOID:4159 / skin cancer [ cosmic ]
T290 S290 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y302 C302 Biomuta DOID:363 / uterine cancer [ icgc ]
S332 I332 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S332 N332 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S332 T332 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K426 T426 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S546 R546 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S558 I558 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S561 T561 Biomuta DOID:1319 / brain cancer [ cosmic ]