Protein Information

Cytoscape View


UniProt AC / UniProt ID P04233 / HG2A_HUMAN
Protein Name HLA class II histocompatibility antigen gamma chain
Gene Name Name: CD74
Synonyms:DHLAG;
Organism Homo sapiens (Human)

PRO ID PR:P04233
DAG View
PRO Name HLA class II histocompatibility antigen gamma chain (human)
Definition An MHC class II histocompatibility antigen gamma chain that is encoded in the genome of human.
Short Label hCD74
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04233 (CD74) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
S25 Phosphorylation phospho.ELM   PhosphoSitePlus 2507633
S42 Phosphorylation phospho.ELM   PhosphoSitePlus 2507633
K43 Ubiquitination PhosphoSitePlus
S45 Phosphorylation phospho.ELM   PhosphoSitePlus 2507633
K80 Ubiquitination PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K99 Methylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
N136 N-Glycosylation UniProt 19159218
K159 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S197 O-Glycosylation PhosphoSitePlus
T203 O-Glycosylation PhosphoSitePlus   UniProt 23234360, 22171320
N256 N-Glycosylation UniProt 10022822
S281 O-Glycosylation UniProt 23234360
T287 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 2507633
S42 Phosphorylation HPRD 2507633
S45 Phosphorylation HPRD 2507633


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S25 P25 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S42 R42 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S45 R45 Biomuta DOID:8618 / oral cavity cancer [ icgc ]