iPTMnet Report for P04233 (CD74)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04233 / HG2A_HUMAN
Protein Name HLA class II histocompatibility antigen gamma chain
Gene Name Name: CD74
Synonyms:DHLAG;
Organism Homo sapiens (Human)

PRO ID PR:P04233
DAG View
PRO Name HLA class II histocompatibility antigen gamma chain (human)
Definition An MHC class II histocompatibility antigen gamma chain that is encoded in the genome of human.
Short Label hCD74
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04233 (CD74) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
S25 Phosphorylation phospho.ELM   PhosphoSitePlus 2507633
S42 Phosphorylation phospho.ELM   PhosphoSitePlus 2507633
K43 Ubiquitination PhosphoSitePlus
C44 Methylation IEDB 31844290
S45 Phosphorylation phospho.ELM   PhosphoSitePlus 2507633
T66 O-Glycosylation GlyGen 29351928
K80 Ubiquitination PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K99 Methylation PhosphoSitePlus
N130 N-Glycosylation GlyGen 29741879, 24190977
T132 Phosphorylation PhosphoSitePlus
N136 N-Glycosylation GlyGen   UniProt 29741879, 32125861, 19159218, ...24190977
N148 N-Glycosylation GlyGen 24190977
K159 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S197 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T203 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 23234360, 22171320
N256 N-Glycosylation GlyGen   UniProt 10022822
N270 N-Glycosylation GlyGen 24190977
S281 O-Glycosylation GlyGen   UniProt 23234360, 22171320
S282 O-Glycosylation GlyGen   UniProt 25326458, 36213313, 32337544, ...22171320
T287 O-Glycosylation GlyGen 22171320
T287 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 2507633
S42 Phosphorylation HPRD 2507633
S45 Phosphorylation HPRD 2507633


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S42 R42 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S42 N42 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S45 R45 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K99 R99 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S281 P281 Biomuta DOID:2531 / hematologic cancer [ icgc ]