iPTMnet Report for P04198 (MYCN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04198 / MYCN_HUMAN
Protein Name N-myc proto-oncogene protein
Gene Name Name: MYCN
Synonyms:BHLHE37,NMYC;
Organism Homo sapiens (Human)

PRO ID PR:P04198
DAG View
PRO Name N-myc proto-oncogene protein (human)
Definition An N-myc proto-oncogene protein that is encoded in the genome of human.
Short Label hMYCN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04198 (MYCN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation phospho.ELM 18669648
S5 Phosphorylation phospho.ELM 18669648
T6 Phosphorylation phospho.ELM 18669648
S7 Phosphorylation phospho.ELM 18669648
T8 Phosphorylation phospho.ELM 18669648
T43 Phosphorylation RLIMS-P 32501498
K52 Ubiquitination PhosphoSitePlus
T58 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 27935099, 27571165, 15302935, ...33741928, 32501498, 25477524, 26456864
S62 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 31690716, 18220336, 27571165, ...15302935, 21659604, 34258104, 32501498, 20068231
S64 Phosphorylation PhosphoSitePlus
R65 Methylation PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
S149 Phosphorylation RLIMS-P 32501498
S156 Phosphorylation PhosphoSitePlus   RLIMS-P 32501498
R238 Methylation PhosphoSitePlus
R242 Methylation PhosphoSitePlus
S261 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 1425701
S263 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 1425701
K321 Ubiquitination PhosphoSitePlus
S352 O-Glycosylation GlyGen 30379171
S355 Phosphorylation PhosphoSitePlus   RLIMS-P 32501498


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 I3 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S5 T5 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T6 K6 Biomuta DOID:1324 / lung cancer [ cosmic ]
T6 M6 Biomuta DOID:1324 / lung cancer [ cosmic ]
S7 F7 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T58 M58 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T58 K58 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S62 L62 Biomuta DOID:4159 / skin cancer [ cosmic ]
S64 G64 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R242 H242 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R242 L242 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K321 R321 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]