iPTMnet Report for P04156 (PRNP)
Protein Information
| UniProt AC / UniProt ID | P04156 / PRIO_HUMAN |
| Protein Name | Major prion protein precursor |
| Gene Name | Name: PRNP Synonyms:ALTPRP,PRIP,PRP; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P04156 |
| PRO Name | major prion protein (human) |
| Definition | A PRNP gene translation product (human) that is encoded by the major prion protein open reading frame, as opposed to the alternate reading frame. |
| Short Label | hPRNP/iso:major |
| Category | organism-seqgroup |
DAG ViewP04156 (PRNP) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y38 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S43 | Phosphorylation | Q00535 (CDK5) | score2 | PhosphoSitePlus | 25572400 | |
| T95 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| Y145 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N181 | N-Glycosylation | score3 | GlyGen UniProt | 12214108 | ||
| T193 | O-Glycosylation | score1 | PhosphoSitePlus | |||
| K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N197 | N-Glycosylation | score2 | GlyGen UniProt | 24190977, 29671580, 19349973 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y145 | C145 | Biomuta | DOID:1324 / lung cancer [ icgc ] |
