iPTMnet Report for P04150 (NR3C1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04150 / GCR_HUMAN
Protein Name Glucocorticoid receptor
Gene Name Name: NR3C1
Synonyms:GRL;
Organism Homo sapiens (Human)

PRO ID PR:P04150
DAG View
PRO Name glucocorticoid receptor (human)
Definition A glucocorticoid receptor that is encoded in the genome of human.
Short Label hNR3C1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04150 (NR3C1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S6 Phosphorylation PhosphoSitePlus
T8 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y30 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
R34 Methylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S42 O-Glycosylation GlyGen 34846842, 33214551, 35254053, ...30379171, 32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092
S44 O-Glycosylation GlyGen 34846842, 33214551, 30379171, ...32574038, 34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S44 Phosphorylation PhosphoSitePlus
S45 O-Glycosylation GlyGen 34846842, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 28657654, 29237092, 30059200
S45 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S47 O-Glycosylation GlyGen 34846842, 33214551, 30379171, ...32574038, 34019948, 28657654, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 31373491, 29237092, 30059200
S52 O-Glycosylation GlyGen 34846842, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 28657654, 29237092, 30059200
S54 O-Glycosylation GlyGen 34846842, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 28657654, 29237092, 30059200
S54 Phosphorylation PhosphoSitePlus
S56 O-Glycosylation GlyGen 34846842, 33214551, 30379171, ...32574038, 34019948, 35254053, 35132862, 31492838, 29351928, 35289036, 30620550, 28657654, 29237092, 30059200
S56 Phosphorylation PhosphoSitePlus
K57 Sumoylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
S113 Phosphorylation phospho.ELM 7873448, 2019585
S125 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
S134 Phosphorylation P31749 (AKT1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33235235, 21930780, 18669648, ...32357907, 24291004, 30414425, 27717743, 26825173
K140 Ubiquitination PhosphoSitePlus
S141 Phosphorylation phospho.ELM 7873448, 2019585
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S203 Phosphorylation Q00535 (CDK5) , Q16539 (MAPK14) , O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33235235, 24275569, 27220430, ...17185395, 23704983, 24024586, 20086048, 18483179, 29133811, 25847991, 18304804, 12000743, 25511704, 23593222, 21483429, 17440046, 23650397
K206 Ubiquitination PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
S211 Phosphorylation Q16539 (MAPK14) , Q00535 (CDK5) , O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22745689, 17391526, 29876006, ...17185395, 23704983, 26993765, 31354714, 27579615, 33235235, 32871225, 28808239, 19359101, 18304804, 30414425, 25511704, 23593222, 20156337, 29163463, 27220430, 22285804, 21829454, 18483179, 24166279, 24795534, 28751734, 29133811, 19729027, 23152905, 28582465, 23650397, 18682536, 15817653, 24030073, 32394161, 21267416, 12000743, 20660302, 21483429, 20561560, 20086048, 19841061, 28827617, 19586900, 25678784, 19101597, 23239753, 17440046, 25847991
S226 Phosphorylation Q16539 (MAPK14) , P45983 (MAPK8) , Q00535 (CDK5) , P28482 (MAPK1) , Q15759 (MAPK11) , P53779 (MAPK10) , P45984 (MAPK9) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25355489, 33235235, 17185395, ...23704983, 21474440, 18304804, 30414425, 25511704, 18483179, 22911818, 29133811, 23123359, 28582465, 26052031, 22205926, 18337589, 21483429, 20561560, 19812390, 20086048, 9199329, 18669648, 20156337, 17440046, 12351702
S234 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S241 Phosphorylation PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S267 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 33235235, 23186163, 18669648
T272 Phosphorylation PhosphoSitePlus
K277 Sumoylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
K293 Sumoylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
C302 Methylation IEDB 31844290
S305 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
K348 Sumoylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S404 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor   UniProt 18838540
C441 Methylation IEDB 31844290
K480 Acetylation PhosphoSitePlus   UniProt 19141540
K492 Acetylation PhosphoSitePlus   UniProt 19141540
K494 Acetylation PhosphoSitePlus   UniProt 19141540
K495 Acetylation PhosphoSitePlus   UniProt 19141540
K498 Sumoylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
S508 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 9038175
T519 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus   RLIMS-P 33744286
T556 Phosphorylation PhosphoSitePlus
T562 Phosphorylation PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
C665 Methylation IEDB 31844290
T668 Phosphorylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
K681 Sumoylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
K703 Sumoylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 18691976, 18669648
T32 Phosphorylation HPRD 20068231
T38 Phosphorylation HPRD 20068231
S45 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19691289, 20068231
S113 Phosphorylation HPRD 20068231, 7873448, 2019585
S134 Phosphorylation HPRD 18669648
S141 Phosphorylation HPRD 7873448, 2019585
S203 Phosphorylation HPRD 12000743
S211 Phosphorylation HPRD 12000743
S226 Phosphorylation P28482 (MAPK1) , P45983 (MAPK8) HPRD 18669648, 9199329, 12351702
S234 Phosphorylation HPRD 18669648
S266 Phosphorylation HPRD 18691976
S267 Phosphorylation HPRD 19651622, 18669648, 20068231
S508 Phosphorylation P78527 (PRKDC) HPRD 9038175
Y648 Phosphorylation HPRD 20068231
S650 Phosphorylation HPRD 20068231
S651 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 18691976, 18669648
T32 Phosphorylation HPRD 20068231
T38 Phosphorylation HPRD 20068231
S45 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19691289, 20068231
S113 Phosphorylation HPRD 20068231, 7873448, 2019585
S134 Phosphorylation HPRD 18669648
S141 Phosphorylation HPRD 7873448, 2019585
S203 Phosphorylation HPRD 12000743
S211 Phosphorylation HPRD 12000743
S226 Phosphorylation P45983 (MAPK8) , P28482 (MAPK1) HPRD 18669648, 9199329, 12351702
S234 Phosphorylation HPRD 18669648
S266 Phosphorylation HPRD 18691976
S267 Phosphorylation HPRD 19651622, 18669648, 20068231
S508 Phosphorylation P78527 (PRKDC) HPRD 9038175
Y648 Phosphorylation HPRD 20068231
S650 Phosphorylation HPRD 20068231
S651 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 18691976, 18669648
T32 Phosphorylation HPRD 20068231
T38 Phosphorylation HPRD 20068231
S45 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19691289, 20068231
S113 Phosphorylation HPRD 20068231, 7873448, 2019585
S134 Phosphorylation HPRD 18669648
S141 Phosphorylation HPRD 7873448, 2019585
S203 Phosphorylation HPRD 12000743
S211 Phosphorylation HPRD 12000743
S226 Phosphorylation P28482 (MAPK1) , P45983 (MAPK8) HPRD 18669648, 9199329, 12351702
S234 Phosphorylation HPRD 18669648
S266 Phosphorylation HPRD 18691976
S267 Phosphorylation HPRD 19651622, 18669648, 20068231
S509 Phosphorylation P78527 (PRKDC) HPRD 9038175
Y649 Phosphorylation HPRD 20068231
S651 Phosphorylation HPRD 20068231
S652 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04150 (NR3C1) T524 P27348 (YWHAQ) unknown eFIP 33744286
Phosphorylation P04150 (NR3C1) S211 Q16539 (MAPK14) unknown eFIP 22285804
Phosphorylation P04150 (NR3C1) S211 O60244 (MED14) increased_association eFIP 18483179


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S42 Y42 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S54 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S79 F79 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K96 R96 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, cosmic, cosmic, icgc, cosmic ]
S113 F113 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S132 L132 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K140 N140 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T208 A208 Biomuta DOID:1319 / brain cancer [ cosmic ]
S234 P234 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S241 L241 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S241 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S266 * Biomuta DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K277 R277 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K280 N280 Biomuta DOID:263 / kidney cancer [ cosmic ]
C302 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C302 F302 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S404 Y404 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
C441 Y441 Biomuta DOID:1319 / brain cancer [ cosmic ]
S508 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S509 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T519 P519 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T524 M524 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T524 A524 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T556 S556 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T562 M562 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T594 I594 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S617 T617 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S650 F650 Biomuta DOID:4159 / skin cancer [ cosmic ]
S651 F651 Biomuta DOID:4159 / skin cancer [ cosmic ]
T668 P668 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K695 E695 Biomuta DOID:1324 / lung cancer [ cosmic ]
S746 G746 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]